Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM193121'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM193121 (US9193736, 37) Show SMILES Oc1nc(no1)-c1ccc(cn1)-c1c(CCc2ccc3ccccc3n2)nc2c(ccnn12)N1CCOCC1 Show InChI InChI=1S/C28H24N8O3/c37-28-33-26(34-39-28)23-9-6-19(17-29-23)25-22(10-8-20-7-5-18-3-1-2-4-21(18)31-20)32-27-24(11-12-30-36(25)27)35-13-15-38-16-14-35/h1-7,9,11-12,17H,8,10,13-16H2,(H,33,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.8	n/a
Janssen Pharmaceutica, NV US Patent					Assay Description Rat recombinant PDE10a (rPDE10a) was expressed in Sf9 cells using a recombinant rPDE10a baculovirus construct. Cells were harvested after 48 h of inf...				US Patent US9193736 (2015) BindingDB Entry DOI: 10.7270/Q2XK8DCS
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