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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50014825'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM50014825
PNG
(CHEMBL3262031)
Show SMILES COCCn1cc(cn1)-c1c(nc2c(nccn12)N1CCOCC1)C1CC1
Show InChI InChI=1S/C19H24N6O2/c1-26-9-8-24-13-15(12-21-24)17-16(14-2-3-14)22-19-18(20-4-5-25(17)19)23-6-10-27-11-7-23/h4-5,12-14H,2-3,6-11H2,1H3
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n/an/a 54n/an/an/an/an/an/a



Janssen Research& Development

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...

J Med Chem 57: 4196-212 (2014)


Article DOI: 10.1021/jm500073h
BindingDB Entry DOI: 10.7270/Q2X068K6
More data for this
Ligand-Target Pair