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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50130766'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50130766
PNG
(CHEMBL3634861)
Show SMILES Cn1c(-c2ccc(F)cc2)c(ccc1=O)-c1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C28H21FN2O2/c1-31-27(32)17-16-25(28(31)21-6-11-22(29)12-7-21)19-9-14-24(15-10-19)33-18-23-13-8-20-4-2-3-5-26(20)30-23/h2-17H,18H2,1H3
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Article
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n/an/a 2.99E+3n/an/an/an/an/an/a



Glenmark Research Centre

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...

J Med Chem 58: 8292-308 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01240
BindingDB Entry DOI: 10.7270/Q2833TVD
More data for this
Ligand-Target Pair