Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50402943'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50402943 (CHEMBL2206215) Show SMILES OCC1CCN(CC1)c1cnccc1Oc1ccc(Nc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C24H25N5O2/c30-16-17-10-13-29(14-11-17)22-15-25-12-9-23(22)31-19-7-5-18(6-8-19)26-24-27-20-3-1-2-4-21(20)28-24/h1-9,12,15,17,30H,10-11,13-14,16H2,(H2,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0750	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human PDE10A2 using FAM-cAMP as substrate incubated for 60 mins prior to substrate addition measured after 90 mins by IMAP-FRET assay				Bioorg Med Chem Lett 22: 7371-5 (2012) Article DOI: 10.1016/j.bmcl.2012.10.078 BindingDB Entry DOI: 10.7270/Q2GB257C
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