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Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM99007'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))
BDBM99007
PNG
(US8497265, 463)
Show SMILES Cc1ccc(cn1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)28-18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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PC cid
PC sid
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Similars

US Patent
n/an/a 7.80n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).


US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM99007
PNG
(US8497265, 463)
Show SMILES Cc1ccc(cn1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)28-18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assay


Bioorg Med Chem 22: 6570-85 (2015)


Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q
More data for this
Ligand-Target Pair