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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM99126'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))
BDBM99126
PNG
(US8497265, 875)
Show SMILES C1CC(CCO1)c1cccnc1OC1CCN(CC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H27N3O2/c1-2-6-22-19(4-1)7-8-23(26-22)27-14-9-20(10-15-27)29-24-21(5-3-13-25-24)18-11-16-28-17-12-18/h1-8,13,18,20H,9-12,14-17H2
PDB
MMDB

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PC cid
PC sid
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Similars

US Patent
n/an/a 9.80n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).


US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair