Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D' and Ligand = 'BDBM50471939'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50471939 (CHEMBL343232) Show SMILES Clc1nc2c(NCc3ccccc3)nc(nc2nc1N1CCCC1)N1CCNCC1 Show InChI InChI=1S/C21H25ClN8/c22-17-20(29-10-4-5-11-29)26-19-16(25-17)18(24-14-15-6-2-1-3-7-15)27-21(28-19)30-12-8-23-9-13-30/h1-3,6-7,23H,4-5,8-14H2,(H,24,26,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of cAMP hydrolysis by inhibiting phosphodiesterases (PDE4), isolated from tumor tissue of human large cell lung tumor xenograft LXFL-529, ...				J Med Chem 41: 4733-43 (1998) Article DOI: 10.1021/jm981021v BindingDB Entry DOI: 10.7270/Q2SN0CQ8
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