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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D' and Ligand = 'BDBM50484444'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50484444
PNG
(3,3-Bis(3,4,5-Trimethoxyphenyl)Acrylonitrile | CHE...)
Show SMILES [#6]-[#8]-c1cc(cc(-[#8]-[#6])c1-[#8]-[#6])-[#6](=[#6]\C#N)\c1cc(-[#8]-[#6])c(-[#8]-[#6])c(-[#8]-[#6])c1
Show InChI InChI=1S/C21H23NO6/c1-23-16-9-13(10-17(24-2)20(16)27-5)15(7-8-22)14-11-18(25-3)21(28-6)19(12-14)26-4/h7,9-12H,1-6H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



Celgene Corporation

Curated by ChEMBL


Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins

Bioorg Med Chem 19: 6356-74 (2011)


Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK
More data for this
Ligand-Target Pair