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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM332064'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM332064
PNG
(US10189854, Compound 16 | [1-[5-(2-Fluoro-5-methox...)
Show SMILES COc1ccc(F)c(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C26H25FN4O3/c1-33-19-3-5-22(27)20(13-19)18-14-28-25(29-15-18)31-16-26(6-7-26)21-4-2-17(12-23(21)31)24(32)30-8-10-34-11-9-30/h2-5,12-15H,6-11,16H2,1H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...

US Patent US10189854 (2019)


BindingDB Entry DOI: 10.7270/Q2N87CW4
More data for this
Ligand-Target Pair