Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM332148'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM332148 (US10189854, Compound 104 | [(2R,6S)-2,6-dimethyl-m...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F Show InChI InChI=1S/C27H27FN4O2/c1-17-14-31(15-18(2)34-17)25(33)19-7-8-22-24(11-19)32(16-27(22)9-10-27)26-29-12-20(13-30-26)21-5-3-4-6-23(21)28/h3-8,11-13,17-18H,9-10,14-16H2,1-2H3/t17-,18+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
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