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Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM355750'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355750
PNG
(N-Cyclopropyl-3-(3,4-dichlorophenyl)-3H-imidazo[4,...)
Show SMILES Clc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12Cl2N4O/c17-11-6-5-10(8-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4B and 4D assays use scintillation proximity assay (SPA) technology to measure the inhibition of human recombinant PDE4B and PDE4D enzyme acti...

US Patent US9815832 (2017)


BindingDB Entry DOI: 10.7270/Q2G1630T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM355750
PNG
(N-Cyclopropyl-3-(3,4-dichlorophenyl)-3H-imidazo[4,...)
Show SMILES Clc1ccc(cc1Cl)-n1c(nc2cccnc12)C(=O)NC1CC1
Show InChI InChI=1S/C16H12Cl2N4O/c17-11-6-5-10(8-12(11)18)22-14-13(2-1-7-19-14)21-15(22)16(23)20-9-3-4-9/h1-2,5-9H,3-4H2,(H,20,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 630n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human C-terminal His-tagged N-terminal GST-tagged PDE4B2 expressed in baculovirus infected Sf9 cells by radioligand binding...

Citation and Details

Article DOI: 10.1021/acsmedchemlett.9b00369
BindingDB Entry DOI: 10.7270/Q2WM1J4P
More data for this
Ligand-Target Pair