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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM50256086'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50256086
PNG
(CHEMBL4103412)
Show SMILES COc1cccc(Nc2cc(nc3CCNC(=O)c23)-c2cccc(c2)-c2cccc(c2)C(=O)NCCN(C)C)c1
Show InChI InChI=1S/C32H33N5O3/c1-37(2)16-15-34-31(38)24-10-5-8-22(18-24)21-7-4-9-23(17-21)28-20-29(30-27(36-28)13-14-33-32(30)39)35-25-11-6-12-26(19-25)40-3/h4-12,17-20H,13-16H2,1-3H3,(H,33,39)(H,34,38)(H,35,36)
PDB

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.230n/an/an/an/an/an/a



Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4B1 using [3H]-cAMP as substrate preincubated for 15 mins followed substrate addition measured after 60 mins by sc...

J Med Chem 61: 2472-2489 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01751
BindingDB Entry DOI: 10.7270/Q2HQ42BB
More data for this
Ligand-Target Pair