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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM50495761'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50495761
PNG
(CHEMBL3114949)
Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2cc(F)c(CC(O)=O)cc2F)n1
Show InChI InChI=1S/C22H18F3N3O5S/c1-33-18-5-4-11(7-15(18)25)21-26-16-3-2-6-34(31,32)20(16)22(28-21)27-17-10-13(23)12(8-14(17)24)9-19(29)30/h4-5,7-8,10H,2-3,6,9H2,1H3,(H,29,30)(H,26,27,28)
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins

Bioorg Med Chem Lett 24: 893-9 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.076
BindingDB Entry DOI: 10.7270/Q2GX4FHW
More data for this
Ligand-Target Pair