Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4D' and Ligand = 'BDBM50495773'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50495773 (CHEMBL3114921) Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(=O)NCC(C)(C)C)cc2)n1 Show InChI InChI=1S/C27H31FN4O4S/c1-27(2,3)16-29-23(33)14-17-7-10-19(11-8-17)30-26-24-21(6-5-13-37(24,34)35)31-25(32-26)18-9-12-22(36-4)20(28)15-18/h7-12,15H,5-6,13-14,16H2,1-4H3,(H,29,33)(H,30,31,32)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4D2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
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