Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase' and Ligand = 'BDBM292712'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM292712 (8-Chloro-1-(2,5-dichlorophenyl)-3-methyl-1H-pyrazo...) Show SMILES Cc1nn(-c2cc(Cl)ccc2Cl)c2c1c(=O)[nH]c1ccc(Cl)nc21 Show InChI InChI=1S/C16H9Cl3N4O/c1-7-13-15(14-10(20-16(13)24)4-5-12(19)21-14)23(22-7)11-6-8(17)2-3-9(11)18/h2-6H,1H3,(H,20,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
INTRA-CELLULAR THERAPIES, INC. US Patent					Assay Description r-hPDE2A (Accession No. NM_002599, Homo sapiens phosphodiesterase 2A, cGMP-stimulated, transcript variant 1) A mammalian expression cloning vector wi...				US Patent US10543194 (2020) BindingDB Entry DOI: 10.7270/Q2F47RJZ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM292712 (8-Chloro-1-(2,5-dichlorophenyl)-3-methyl-1H-pyrazo...) Show SMILES Cc1nn(-c2cc(Cl)ccc2Cl)c2c1c(=O)[nH]c1ccc(Cl)nc21 Show InChI InChI=1S/C16H9Cl3N4O/c1-7-13-15(14-10(20-16(13)24)4-5-12(19)21-14)23(22-7)11-6-8(17)2-3-9(11)18/h2-6H,1H3,(H,20,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	73	n/a	n/a	n/a	n/a	7.2	25
INTRA-CELLULAR THERAPIES, INC. US Patent					Assay Description Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...				US Patent US10105349 (2018) BindingDB Entry DOI: 10.7270/Q2QN68T1
					More data for this Ligand-Target Pair