Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B' and Ligand = 'BDBM50474158'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Homo sapiens (Human))	BDBM50474158 (CHEMBL61667) Show SMILES COc1ccc(cc1Cl)C1=NN(C(=O)C2CC=CCC12)c1ccc(cc1)C1=NNC(=O)CC1C |c:17,t:10,30| Show InChI InChI=1S/C26H25ClN4O3/c1-15-13-23(32)28-29-24(15)16-7-10-18(11-8-16)31-26(33)20-6-4-3-5-19(20)25(30-31)17-9-12-22(34-2)21(27)14-17/h3-4,7-12,14-15,19-20H,5-6,13H2,1-2H3,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Inhibition of dual cGMP-inhibited phosphodiesterase 3 (PDE3) was determined in homogenates from human platelets.				J Med Chem 46: 2008-16 (2003) Article DOI: 10.1021/jm030776l BindingDB Entry DOI: 10.7270/Q2S1857B
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