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Compile Data Set for Download or QSAR

Found 747 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 10641   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM397172
PNG
(US10596172, Compound I-243 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cn1
Show InChI InChI=1S/C19H17FN6O2/c1-3-16(27)23-12-5-4-6-13(9-12)24-18-15(20)11-22-19(26-18)25-14-7-8-17(28-2)21-10-14/h3-11H,1H2,2H3,(H,23,27)(H2,22,24,25,26)
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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM397264
PNG
(US10596172, Compound I-244 | US10828300, Compound ...)
Show SMILES Fc1cnc(Nc2cccc(OC(F)(F)F)c2)nc1Nc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C20H15F4N5O2/c1-2-17(30)26-12-5-3-6-13(9-12)27-18-16(21)11-25-19(29-18)28-14-7-4-8-15(10-14)31-20(22,23)24/h2-11H,1H2,(H,26,30)(H2,25,27,28,29)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM397265
PNG
(US10596172, Compound I-245 | US10828300, Compound ...)
Show SMILES FC(F)(F)c1cnc(Nc2ccccc2)nc1Nc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C20H16F3N5O/c1-2-17(29)25-14-9-6-10-15(11-14)26-18-16(20(21,22)23)12-24-19(28-18)27-13-7-4-3-5-8-13/h2-12H,1H2,(H,25,29)(H2,24,26,27,28)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM397266
PNG
(US10596172, Compound I-247 | US10828300, Compound ...)
Show SMILES Fc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1
Show InChI InChI=1S/C19H15F2N5O/c1-2-17(27)23-14-4-3-5-15(10-14)24-18-16(21)11-22-19(26-18)25-13-8-6-12(20)7-9-13/h2-11H,1H2,(H,23,27)(H2,22,24,25,26)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM397267
PNG
(US10596172, Compound I-248 | US10828300, Compound ...)
Show SMILES Cc1cnc(Nc2ccccc2)nc1Oc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C20H18N4O2/c1-3-18(25)22-16-10-7-11-17(12-16)26-19-14(2)13-21-20(24-19)23-15-8-5-4-6-9-15/h3-13H,1H2,2H3,(H,22,25)(H,21,23,24)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM437958
PNG
(US10596172, Compound I-360 | US10828300, Compound ...)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(Nc2ncc(C)c(Nc3cccc(C)c3)n2)c1
Show InChI InChI=1S/C24H28N6O/c1-17-8-5-9-19(14-17)27-23-18(2)16-25-24(29-23)28-21-11-6-10-20(15-21)26-22(31)12-7-13-30(3)4/h5-12,14-16H,13H2,1-4H3,(H,26,31)(H2,25,27,28,29)/b12-7+
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397221
PNG
(US10596172, Compound I-167 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(C3CC3)c(Nc3cccc(NC(=O)C=C)c3)n2)cn1
Show InChI InChI=1S/C22H22N6O2/c1-3-19(29)25-15-5-4-6-16(11-15)26-21-18(14-7-8-14)13-24-22(28-21)27-17-9-10-20(30-2)23-12-17/h3-6,9-14H,1,7-8H2,2H3,(H,25,29)(H2,24,26,27,28)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397222
PNG
(US10596172, Compound I-168 | US10828300, Compound ...)
Show SMILES CC(=O)c1cnc(Nc2ccc(nc2)N2CCOCC2)nc1Nc1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C26H27N7O4/c1-3-24(35)33-10-13-37-22-6-4-18(14-21(22)33)29-25-20(17(2)34)16-28-26(31-25)30-19-5-7-23(27-15-19)32-8-11-36-12-9-32/h3-7,14-16H,1,8-13H2,2H3,(H2,28,29,30,31)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397223
PNG
(US10596172, Compound I-169 | US10828300, Compound ...)
Show SMILES CC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1Nc1ccc2OCCN(C(=O)C=C)c2c1
Show InChI InChI=1S/C27H28N6O4/c1-3-25(35)33-12-15-37-24-9-6-20(16-23(24)33)29-26-22(18(2)34)17-28-27(31-26)30-19-4-7-21(8-5-19)32-10-13-36-14-11-32/h3-9,16-17H,1,10-15H2,2H3,(H2,28,29,30,31)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM437836
PNG
(US10596172, Compound I-170 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(C(C)=O)c(Nc3ccc4OCCN(C(=O)C=C)c4c3)n2)cn1
Show InChI InChI=1S/C23H22N6O4/c1-4-21(31)29-9-10-33-19-7-5-15(11-18(19)29)26-22-17(14(2)30)13-25-23(28-22)27-16-6-8-20(32-3)24-12-16/h4-8,11-13H,1,9-10H2,2-3H3,(H2,25,26,27,28)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397226
PNG
(US10596172, Compound I-173 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(C#N)c(Nc3cccc(NC(=O)C=C)c3)n2)cn1
Show InChI InChI=1S/C20H17N7O2/c1-3-17(28)24-14-5-4-6-15(9-14)25-19-13(10-21)11-23-20(27-19)26-16-7-8-18(29-2)22-12-16/h3-9,11-12H,1H2,2H3,(H,24,28)(H2,23,25,26,27)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397227
PNG
(US10596172, Compound I-174 | US10828300, Compound ...)
Show SMILES Fc1cnc(Nc2ccc3OCCNc3c2)nc1Nc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H19FN6O2/c1-2-19(29)25-13-4-3-5-14(10-13)26-20-16(22)12-24-21(28-20)27-15-6-7-18-17(11-15)23-8-9-30-18/h2-7,10-12,23H,1,8-9H2,(H,25,29)(H2,24,26,27,28)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397234
PNG
(US10596172, Compound I-185 | US10828300, Compound ...)
Show SMILES CC(=C)C(=O)c1ccc(Nc2nc(Nc3ccccc3)ncc2F)cc1
Show InChI InChI=1S/C20H17FN4O/c1-13(2)18(26)14-8-10-16(11-9-14)23-19-17(21)12-22-20(25-19)24-15-6-4-3-5-7-15/h3-12H,1H2,2H3,(H2,22,23,24,25)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397235
PNG
(US10596172, Compound I-186 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(C)c(Oc3cccc(NC(=O)C=C)c3)n2)cn1
Show InChI InChI=1S/C20H19N5O3/c1-4-17(26)23-14-6-5-7-16(10-14)28-19-13(2)11-22-20(25-19)24-15-8-9-18(27-3)21-12-15/h4-12H,1H2,2-3H3,(H,23,26)(H,22,24,25)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397236
PNG
(US10596172, Compound I-188 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(C(C)=O)c(Oc3cccc(NC(=O)C=C)c3)n2)cn1
Show InChI InChI=1S/C21H19N5O4/c1-4-18(28)24-14-6-5-7-16(10-14)30-20-17(13(2)27)12-23-21(26-20)25-15-8-9-19(29-3)22-11-15/h4-12H,1H2,2-3H3,(H,24,28)(H,23,25,26)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397237
PNG
(US10596172, Compound I-189 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(C(C)=O)c(Nc3cccc(NC(=O)C=C)c3)n2)cn1
Show InChI InChI=1S/C21H20N6O3/c1-4-18(29)24-14-6-5-7-15(10-14)25-20-17(13(2)28)12-23-21(27-20)26-16-8-9-19(30-3)22-11-16/h4-12H,1H2,2-3H3,(H,24,29)(H2,23,25,26,27)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM437858
PNG
(US10596172, Compound I-192 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(OC)c(Nc3cccc(NC(=O)C=C)c3)n2)cn1
Show InChI InChI=1S/C20H20N6O3/c1-4-17(27)23-13-6-5-7-14(10-13)24-19-16(28-2)12-22-20(26-19)25-15-8-9-18(29-3)21-11-15/h4-12H,1H2,2-3H3,(H,23,27)(H2,22,24,25,26)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM397240
PNG
(US10596172, Compound I-194 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(F)c(Nc3ccc4OCCN(C(=O)C=C)c4c3)n2)cn1
Show InChI InChI=1S/C21H19FN6O3/c1-3-19(29)28-8-9-31-17-6-4-13(10-16(17)28)25-20-15(22)12-24-21(27-20)26-14-5-7-18(30-2)23-11-14/h3-7,10-12H,1,8-9H2,2H3,(H2,24,25,26,27)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397242
PNG
(US10596172, Compound I-198 | US10828300, Compound ...)
Show SMILES CC(C)(C)OC(=O)NCCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1
Show InChI InChI=1S/C27H31FN6O4/c1-5-23(35)31-19-8-6-9-20(16-19)32-24-22(28)17-30-25(34-24)33-18-10-12-21(13-11-18)37-15-7-14-29-26(36)38-27(2,3)4/h5-6,8-13,16-17H,1,7,14-15H2,2-4H3,(H,29,36)(H,31,35)(H2,30,32,33,34)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397244
PNG
(US10828300, Compound I-200 | US11351168, Compound ...)
Show SMILES COc1cccc(Nc2ncc(C(=O)Nc3ccccc3)c(Oc3cccc(NC(=O)C=C)c3)n2)c1
Show InChI InChI=1S/C27H23N5O4/c1-3-24(33)29-19-11-8-14-22(16-19)36-26-23(25(34)30-18-9-5-4-6-10-18)17-28-27(32-26)31-20-12-7-13-21(15-20)35-2/h3-17H,1H2,2H3,(H,29,33)(H,30,34)(H,28,31,32)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397254
PNG
(US10596172, Compound I-218 | US10828300, Compound ...)
Show SMILES COc1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)cn1
Show InChI InChI=1S/C20H17F3N6O2/c1-3-16(30)26-12-5-4-6-13(9-12)27-18-15(20(21,22)23)11-25-19(29-18)28-14-7-8-17(31-2)24-10-14/h3-11H,1H2,2H3,(H,26,30)(H2,25,27,28,29)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397260
PNG
(US10596172, Compound I-233 | US10828300, Compound ...)
Show SMILES CN(C)CCOc1cccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)c1
Show InChI InChI=1S/C23H25FN6O2/c1-4-21(31)26-16-7-5-8-17(13-16)27-22-20(24)15-25-23(29-22)28-18-9-6-10-19(14-18)32-12-11-30(2)3/h4-10,13-15H,1,11-12H2,2-3H3,(H,26,31)(H2,25,27,28,29)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397265
PNG
(US10596172, Compound I-245 | US10828300, Compound ...)
Show SMILES FC(F)(F)c1cnc(Nc2ccccc2)nc1Nc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C20H16F3N5O/c1-2-17(29)25-14-9-6-10-15(11-14)26-18-16(20(21,22)23)12-24-19(28-18)27-13-7-4-3-5-8-13/h2-12H,1H2,(H,25,29)(H2,24,26,27,28)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397267
PNG
(US10596172, Compound I-248 | US10828300, Compound ...)
Show SMILES Cc1cnc(Nc2ccccc2)nc1Oc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C20H18N4O2/c1-3-18(25)22-16-10-7-11-17(12-16)26-19-14(2)13-21-20(24-19)23-15-8-5-4-6-9-15/h3-13H,1H2,2H3,(H,22,25)(H,21,23,24)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397373
PNG
(US10596172, Compound I-328 | US10828300, Compound ...)
Show SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(CC(=O)C(C)=C)c3)n2)cc1F
Show InChI InChI=1S/C24H24F2N4O3/c1-15(2)21(31)12-16-5-4-6-17(11-16)28-23-20(26)14-27-24(30-23)29-18-7-8-22(19(25)13-18)33-10-9-32-3/h4-8,11,13-14H,1,9-10,12H2,2-3H3,(H2,27,28,29,30)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397377
PNG
(US10596172, Compound I-334 | US10828300, Compound ...)
Show SMILES OCC(O)COc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1F
Show InChI InChI=1S/C22H21F2N5O4/c1-2-20(32)26-13-4-3-5-14(8-13)27-21-18(24)10-25-22(29-21)28-15-6-7-19(17(23)9-15)33-12-16(31)11-30/h2-10,16,30-31H,1,11-12H2,(H,26,32)(H2,25,27,28,29)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397378
PNG
(US10596172, Compound I-335 | US10828300, Compound ...)
Show SMILES OCC(O)COc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1
Show InChI InChI=1S/C22H22FN5O4/c1-2-20(31)25-15-4-3-5-16(10-15)26-21-19(23)11-24-22(28-21)27-14-6-8-18(9-7-14)32-13-17(30)12-29/h2-11,17,29-30H,1,12-13H2,(H,25,31)(H2,24,26,27,28)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397379
PNG
(US10596172, Compound I-339 | US10828300, Compound ...)
Show SMILES OCC(O)COc1cccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)c1
Show InChI InChI=1S/C22H22FN5O4/c1-2-20(31)25-14-5-3-6-15(9-14)26-21-19(23)11-24-22(28-21)27-16-7-4-8-18(10-16)32-13-17(30)12-29/h2-11,17,29-30H,1,12-13H2,(H,25,31)(H2,24,26,27,28)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397388
PNG
(US10596172, Compound I-350 | US10828300, Compound ...)
Show SMILES COCCOc1ccc(Nc2ncc(C#N)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1F
Show InChI InChI=1S/C23H21FN6O3/c1-3-21(31)27-16-5-4-6-17(11-16)28-22-15(13-25)14-26-23(30-22)29-18-7-8-20(19(24)12-18)33-10-9-32-2/h3-8,11-12,14H,1,9-10H2,2H3,(H,27,31)(H2,26,28,29,30)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM397390
PNG
(US10596172, Compound I-352 | US10828300, Compound ...)
Show SMILES COCCOc1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)cc1F
Show InChI InChI=1S/C23H21F4N5O3/c1-3-20(33)29-14-5-4-6-15(11-14)30-21-17(23(25,26)27)13-28-22(32-21)31-16-7-8-19(18(24)12-16)35-10-9-34-2/h3-8,11-13H,1,9-10H2,2H3,(H,29,33)(H2,28,30,31,32)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM437958
PNG
(US10596172, Compound I-360 | US10828300, Compound ...)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(Nc2ncc(C)c(Nc3cccc(C)c3)n2)c1
Show InChI InChI=1S/C24H28N6O/c1-17-8-5-9-19(14-17)27-23-18(2)16-25-24(29-23)28-21-11-6-10-20(15-21)26-22(31)12-7-13-30(3)4/h5-12,14-16H,13H2,1-4H3,(H,26,31)(H2,25,27,28,29)/b12-7+
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM437960
PNG
(US10596172, Compound I-363 | US11351168, Compound ...)
Show SMILES Fc1cnc(Nc2ccc(OCCOCCNC(=O)CCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)cc2)nc1Nc1cccc(NC(=O)C=C)c1 |r|
Show InChI InChI=1S/C48H67FN10O10S/c1-2-41(60)54-35-9-5-10-36(31-35)55-46-38(49)32-53-47(59-46)56-34-15-17-37(18-16-34)69-30-29-67-24-21-52-44(63)14-6-13-43(62)51-20-8-23-66-26-28-68-27-25-65-22-7-19-50-42(61)12-4-3-11-40-45-39(33-70-40)57-48(64)58-45/h2,5,9-10,15-18,31-32,39-40,45H,1,3-4,6-8,11-14,19-30,33H2,(H,50,61)(H,51,62)(H,52,63)(H,54,60)(H2,57,58,64)(H2,53,55,56,59)/t39-,40-,45-/m0/s1
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM437962
PNG
(US10596172, Compound I-370 | US11351168, Compound ...)
Show SMILES CC(C)(C)OC(=O)NCCOCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1
Show InChI InChI=1S/C28H33FN6O5/c1-5-24(36)32-20-7-6-8-21(17-20)33-25-23(29)18-31-26(35-25)34-19-9-11-22(12-10-19)39-16-15-38-14-13-30-27(37)40-28(2,3)4/h5-12,17-18H,1,13-16H2,2-4H3,(H,30,37)(H,32,36)(H2,31,33,34,35)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM437966
PNG
(US10596172, Compound I-374 | US11351168, Compound ...)
Show SMILES CC(C)[C@H](N)C(=O)OC[C@@H](C)Oc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1F |r|
Show InChI InChI=1S/C27H30F2N6O4/c1-5-23(36)32-17-7-6-8-18(11-17)33-25-21(29)13-31-27(35-25)34-19-9-10-22(20(28)12-19)39-16(4)14-38-26(37)24(30)15(2)3/h5-13,15-16,24H,1,14,30H2,2-4H3,(H,32,36)(H2,31,33,34,35)/t16-,24+/m1/s1
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM437972
PNG
(US10596172, Compound I-381 | US11351168, Compound ...)
Show SMILES COCCOc1ccc(Nc2nc(Nc3cccc(NC(=O)C=C)c3)ncc2F)cc1
Show InChI InChI=1S/C22H22FN5O3/c1-3-20(29)25-16-5-4-6-17(13-16)27-22-24-14-19(23)21(28-22)26-15-7-9-18(10-8-15)31-12-11-30-2/h3-10,13-14H,1,11-12H2,2H3,(H,25,29)(H2,24,26,27,28)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397142
PNG
(US10596172, Compound I-1 | US10828300, Compound I-...)
Show SMILES Cc1cccc(Nc2ccnc(Nc3cccc(NC(=O)C=C)c3)n2)c1
Show InChI InChI=1S/C20H19N5O/c1-3-19(26)23-16-8-5-9-17(13-16)24-20-21-11-10-18(25-20)22-15-7-4-6-14(2)12-15/h3-13H,1H2,2H3,(H,23,26)(H2,21,22,24,25)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397143
PNG
(US10596172, Compound I-8 | US10828300, Compound I-...)
Show SMILES Cc1cccc(Nc2nc(Nc3cccc(NC(=O)C=C)c3)ncc2C)c1
Show InChI InChI=1S/C21H21N5O/c1-4-19(27)23-17-9-6-10-18(12-17)25-21-22-13-15(3)20(26-21)24-16-8-5-7-14(2)11-16/h4-13H,1H2,2-3H3,(H,23,27)(H2,22,24,25,26)
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TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M]


(Homo sapiens (Human))		BDBM397143
PNG
(US10596172, Compound I-8 | US10828300, Compound I-...)
Show SMILES Cc1cccc(Nc2nc(Nc3cccc(NC(=O)C=C)c3)ncc2C)c1
Show InChI InChI=1S/C21H21N5O/c1-4-19(27)23-17-9-6-10-18(12-17)25-21-22-13-15(3)20(26-21)24-16-8-5-7-14(2)11-16/h4-13H,1H2,2-3H3,(H,23,27)(H2,22,24,25,26)
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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397288
PNG
(US10596172, Compound I-3 | US10828300, Compound I-...)
Show SMILES Cc1cccc(Nc2nc(Nc3cccc(NC(=O)C=C)c3)ncc2F)c1
Show InChI InChI=1S/C20H18FN5O/c1-3-18(27)23-15-8-5-9-16(11-15)25-20-22-12-17(21)19(26-20)24-14-7-4-6-13(2)10-14/h3-12H,1H2,2H3,(H,23,27)(H2,22,24,25,26)
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UniProtKB/SwissProt

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PC cid
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UniChem
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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M]


(Homo sapiens (Human))		BDBM397288
PNG
(US10596172, Compound I-3 | US10828300, Compound I-...)
Show SMILES Cc1cccc(Nc2nc(Nc3cccc(NC(=O)C=C)c3)ncc2F)c1
Show InChI InChI=1S/C20H18FN5O/c1-3-18(27)23-15-8-5-9-16(11-15)25-20-22-12-17(21)19(26-20)24-14-7-4-6-13(2)10-14/h3-12H,1H2,2H3,(H,23,27)(H2,22,24,25,26)
PDB
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UniProtKB/SwissProt

B.MOAD
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397144
PNG
(US10596172, Compound I-4 | US10828300, Compound I-...)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(Nc2ncc(F)c(Nc3cccc(C)c3)n2)c1
Show InChI InChI=1S/C23H25FN6O/c1-16-7-4-8-17(13-16)27-22-20(24)15-25-23(29-22)28-19-10-5-9-18(14-19)26-21(31)11-6-12-30(2)3/h4-11,13-15H,12H2,1-3H3,(H,26,31)(H2,25,27,28,29)/b11-6+
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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M]


(Homo sapiens (Human))		BDBM397144
PNG
(US10596172, Compound I-4 | US10828300, Compound I-...)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(Nc2ncc(F)c(Nc3cccc(C)c3)n2)c1
Show InChI InChI=1S/C23H25FN6O/c1-16-7-4-8-17(13-16)27-22-20(24)15-25-23(29-22)28-19-10-5-9-18(14-19)26-21(31)11-6-12-30(2)3/h4-11,13-15H,12H2,1-3H3,(H,26,31)(H2,25,27,28,29)/b11-6+
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UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397289
PNG
(US10596172, Compound I-5 | US10828300, Compound I-...)
Show SMILES Cc1cnc(Nc2cccc(NC(=O)C=C)c2)nc1Nc1ccccc1
Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-10-7-11-17(12-16)24-20-21-13-14(2)19(25-20)23-15-8-5-4-6-9-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)
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UniProtKB/SwissProt

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PC cid
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UniChem
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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397145
PNG
(US10596172, Compound I-7 | US10828300, Compound IR...)
Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-10-7-11-17(12-16)23-19-14(2)13-21-20(25-19)24-15-8-5-4-6-9-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)
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UniProtKB/SwissProt

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PC cid
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UniChem
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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397290
PNG
(US10828300, Compound I-8 | US11351168, Compound I-...)
Show SMILES Cc1cccc(Nc2nc(Nc3cc(NC(=O)C=C)ccc3C)ncc2C)c1
Show InChI InChI=1S/C22H23N5O/c1-5-20(28)24-18-10-9-15(3)19(12-18)26-22-23-13-16(4)21(27-22)25-17-8-6-7-14(2)11-17/h5-13H,1H2,2-4H3,(H,24,28)(H2,23,25,26,27)
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UniProtKB/SwissProt

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PC cid
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UniChem
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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397293
PNG
(US10596172, Compound I-11 | US10828300, Compound I...)
Show SMILES Cc1cnc(Nc2cccc(c2)S(N)(=O)=O)nc1Nc1ccc2CN(CCc2c1)C(=O)CCl
Show InChI InChI=1S/C22H23ClN6O3S/c1-14-12-25-22(27-17-3-2-4-19(10-17)33(24,31)32)28-21(14)26-18-6-5-16-13-29(20(30)11-23)8-7-15(16)9-18/h2-6,9-10,12H,7-8,11,13H2,1H3,(H2,24,31,32)(H2,25,26,27,28)
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UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397149
PNG
(US10596172, Compound I-35 | US10828300, Compound I...)
Show SMILES Cc1cnc(Nc2cccc(OCC#C)c2)nc1Nc1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H21N5O2/c1-4-12-30-20-11-7-10-19(14-20)27-23-24-15-16(3)22(28-23)26-18-9-6-8-17(13-18)25-21(29)5-2/h1,5-11,13-15H,2,12H2,3H3,(H,25,29)(H2,24,26,27,28)
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UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397150
PNG
(US10596172, Compound I-38 | US10828300, Compound I...)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(Nc2nc(Nc3ccccc3)ncc2C)c1
Show InChI InChI=1S/C23H26N6O/c1-17-16-24-23(27-18-9-5-4-6-10-18)28-22(17)26-20-12-7-11-19(15-20)25-21(30)13-8-14-29(2)3/h4-13,15-16H,14H2,1-3H3,(H,25,30)(H2,24,26,27,28)/b13-8+
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UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397156
PNG
(US10596172, Compound I-56 | US10828300, Compound I...)
Show SMILES Cc1ccc(NC(=O)C=C)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C19H17N5O/c1-3-18(25)22-15-7-6-13(2)17(11-15)24-19-21-10-8-16(23-19)14-5-4-9-20-12-14/h3-12H,1H2,2H3,(H,22,25)(H,21,23,24)
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UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM397173
PNG
(US10596172, Compound I-96 | US10828300, Compound I...)
Show SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1F
Show InChI InChI=1S/C22H21F2N5O3/c1-3-20(30)26-14-5-4-6-15(11-14)27-21-18(24)13-25-22(29-21)28-16-7-8-19(17(23)12-16)32-10-9-31-2/h3-8,11-13H,1,9-10H2,2H3,(H,26,30)(H2,25,27,28,29)
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UniProtKB/SwissProt

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UniChem
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n/an/a<100n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2X92FHZ
More data for this
Ligand-Target Pair
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