Found 144 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 11543 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625349
(US20230322769, Compound 58 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn3CCCc23)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625352
(US20230322769, Compound 65)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCOCC2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625369
(US20230322769, Compound 89)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCN(C)C(=O)C2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.674 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625349
(US20230322769, Compound 58 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn3CCCc23)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625349
(US20230322769, Compound 58 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn3CCCc23)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625352
(US20230322769, Compound 65)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCOCC2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.01 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.02 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625352
(US20230322769, Compound 65)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCOCC2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 1.09 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625349
(US20230322769, Compound 58 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn3CCCc23)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.09 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625348
(US20230322769, Compound 57 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625358
(US20230322769, Compound 78)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(NCC(C)(C)O)cn3ncc(C#N)c23)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625350
(US20230322769, Compound 60 | US20230322769, Compou...)Show SMILES COc1ccc(cn1)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cc2CCCn2n1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625338
(US20230322769, Compound 20)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCP(C)(=O)CC2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.45 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625369
(US20230322769, Compound 89)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCN(C)C(=O)C2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.47 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625351
(US20230322769, Compound 64 | US20230322769, Compou...)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625348
(US20230322769, Compound 57 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.66 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625337
(US20230322769, Compound 17)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CC3CC(C2)N3C)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625342
(US20230322769, Compound 32)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.73 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM296429
(US10112942, Example 163 | US10112942, Example 166 ...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
| n/a | n/a | 1.98 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625348
(US20230322769, Compound 57 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.05 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM296429
(US10112942, Example 163 | US10112942, Example 166 ...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
| n/a | n/a | 2.07 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625342
(US20230322769, Compound 32)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625338
(US20230322769, Compound 20)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCP(C)(=O)CC2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625346
(US20230322769, Compound 51)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn3CCCc23)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM296429
(US10112942, Example 163 | US10112942, Example 166 ...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| | n/a | n/a | 2.17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625348
(US20230322769, Compound 57 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625367
(US20230322769, Compound 87 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCN(C)CC2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 2.26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625335
(US20230322769, Compound 16)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CC3CC(C2)N3)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.42 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625373
(US20230322769, Compound 101)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CC[N+](C)([O-])CC2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625350
(US20230322769, Compound 60 | US20230322769, Compou...)Show SMILES COc1ccc(cn1)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cc2CCCn2n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.54 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625337
(US20230322769, Compound 17)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CC3CC(C2)N3C)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.61 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625367
(US20230322769, Compound 87 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCN(C)CC2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 2.78 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625367
(US20230322769, Compound 87 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCN(C)CC2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625369
(US20230322769, Compound 89)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCN(C)C(=O)C2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.04 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625342
(US20230322769, Compound 32)Show SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625338
(US20230322769, Compound 20)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCP(C)(=O)CC2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625352
(US20230322769, Compound 65)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCOCC2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 3.37 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625335
(US20230322769, Compound 16)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CC3CC(C2)N3)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.65 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625337
(US20230322769, Compound 17)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CC3CC(C2)N3C)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.82 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625346
(US20230322769, Compound 51)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn3CCCc23)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]
(Homo sapiens (Human)) | BDBM625348
(US20230322769, Compound 57 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.06 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625338
(US20230322769, Compound 20)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCP(C)(=O)CC2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M]
(Homo sapiens (Human)) | BDBM625348
(US20230322769, Compound 57 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625348
(US20230322769, Compound 57 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625366
(US20230322769, Compound 86)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CC(C)(O)C2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625358
(US20230322769, Compound 78)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(NCC(C)(C)O)cn3ncc(C#N)c23)cn1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625346
(US20230322769, Compound 51)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn3CCCc23)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.61 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM625367
(US20230322769, Compound 87 | US20230322769, Compou...)Show SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCN(C)CC2)cn1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| | n/a | n/a | 4.62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Search and Browse
