Found 16 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 50036677 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067848
((S)-2-(((3aR,6R,9S)-3a,6,9-trimethyl-3-(6-methylhe...)Show SMILES CC(C)CCCC(C)C1CCC2C3[C@@H](C)CC(=O)[C@](C)(C[C@@H](CC(O)=O)C(O)=O)C3CC[C@]12C Show InChI InChI=1S/C29H48O5/c1-17(2)8-7-9-18(3)21-10-11-22-26-19(4)14-24(30)29(6,23(26)12-13-28(21,22)5)16-20(27(33)34)15-25(31)32/h17-23,26H,7-16H2,1-6H3,(H,31,32)(H,33,34)/t18?,19-,20+,21?,22?,23?,26?,28+,29+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067852
(3-[(3aR,6R,9S)-3-(1,5-Dimethyl-hexyl)-3a,6,9-trime...)Show SMILES CC(C)CCCC(C)C1CCC2C3[C@@H](C)CC(=O)[C@](C)(CCC(O)=O)C3CC[C@]12C Show InChI InChI=1S/C27H46O3/c1-17(2)8-7-9-18(3)20-10-11-21-25-19(4)16-23(28)27(6,15-13-24(29)30)22(25)12-14-26(20,21)5/h17-22,25H,7-16H2,1-6H3,(H,29,30)/t18?,19-,20?,21?,22?,25?,26+,27+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067825
(3-[(R)-3-(1,5-Dimethyl-hexyl)-3a-methyl-7-oxo-dode...)Show SMILES CC(C)CCCC(C)C1CCC2C3CCC(=O)C(CCC(O)=O)C3CC[C@]12C Show InChI InChI=1S/C25H42O3/c1-16(2)6-5-7-17(3)21-10-11-22-19-8-12-23(26)20(9-13-24(27)28)18(19)14-15-25(21,22)4/h16-22H,5-15H2,1-4H3,(H,27,28)/t17?,18?,19?,20?,21?,22?,25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067849
((S)-2-[(3aR,6R,9S)-3-(1,5-Dimethyl-hexyl)-9-ethyl-...)Show SMILES CC[C@H]1CC(=O)[C@](C)(C[C@@H](CC(O)=O)C(O)=O)C2CC[C@]3(C)C(CCC3C12)C(C)CCCC(C)C Show InChI InChI=1S/C30H50O5/c1-7-20-15-25(31)30(6,17-21(28(34)35)16-26(32)33)24-13-14-29(5)22(11-12-23(29)27(20)24)19(4)10-8-9-18(2)3/h18-24,27H,7-17H2,1-6H3,(H,32,33)(H,34,35)/t19?,20-,21+,22?,23?,24?,27?,29+,30+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067834
((3aR,6R)-6-(2-Carboxy-ethyl)-3-(1,5-dimethyl-hexyl...)Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C(C(O)=O)[C@](C)(CCC(O)=O)C3CC[C@]12C |t:14| Show InChI InChI=1S/C27H44O4/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23(25(30)31)27(5,16-14-24(28)29)22(19)13-15-26(20,21)4/h10,17-22H,6-9,11-16H2,1-5H3,(H,28,29)(H,30,31)/t18?,19?,20?,21?,22?,26-,27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067830
((3aR,6R,7R)-6-(2-Carboxy-ethyl)-3-(1,5-dimethyl-he...)Show SMILES CC(C)CCCC(C)C1CCC2C3CC[C@@H](C(O)=O)[C@](C)(CCC(O)=O)C3CC[C@]12C Show InChI InChI=1S/C27H46O4/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23(25(30)31)27(5,16-14-24(28)29)22(19)13-15-26(20,21)4/h17-23H,6-16H2,1-5H3,(H,28,29)(H,30,31)/t18?,19?,20?,21?,22?,23-,26+,27+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067851
(CHEMBL141267 | methyl 3-[3a,6-dimethyl-5,7-dioxo-(...)Show SMILES COC(=O)CC[C@]1(C)C2C(CCC1=O)C1CC[C@@]3(OCOC33COCO3)[C@@]1(C)CC2=O Show InChI InChI=1S/C23H32O8/c1-20(8-7-18(26)27-3)17(25)5-4-14-15-6-9-22(21(15,2)10-16(24)19(14)20)23(31-13-29-22)11-28-12-30-23/h14-15,19H,4-13H2,1-3H3/t14?,15?,19?,20-,21-,22+,23?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067819
(3-[3a,6-dimethyl-5,7-dioxo-(3'R,3aS,6R)-dispiro[pe...)Show SMILES C[C@]12CC(=O)C3C(CCC(=O)[C@]3(C)CCC(O)=O)C1CC[C@@]21OCOC11COCO1 Show InChI InChI=1S/C22H30O8/c1-19(7-6-17(25)26)16(24)4-3-13-14-5-8-21(20(14,2)9-15(23)18(13)19)22(30-12-28-21)10-27-11-29-22/h13-14,18H,3-12H2,1-2H3,(H,25,26)/t13?,14?,18?,19-,20-,21+,22?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067847
(4-[(3aR,6R,9S)-6-(2-Carboxy-ethyl)-3a,6,9-trimethy...)Show SMILES CC(CCC(O)=O)C1CCC2C3[C@@H](C)CC(=O)[C@](C)(CCC(O)=O)C3CC[C@]12C Show InChI InChI=1S/C24H38O5/c1-14(5-8-20(26)27)16-6-7-17-22-15(2)13-19(25)24(4,12-10-21(28)29)18(22)9-11-23(16,17)3/h14-18,22H,5-13H2,1-4H3,(H,26,27)(H,28,29)/t14?,15-,16?,17?,18?,22?,23+,24+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067826
(3-[(3aR,6R)-3-(1,5-Dimethyl-hexyl)-3a,6-dimethyl-7...)Show SMILES CC(C)CCCC(C)C1CCC2C3CCC(=O)[C@](C)(CCC(O)=O)C3CC[C@]12C Show InChI InChI=1S/C26H44O3/c1-17(2)7-6-8-18(3)20-10-11-21-19-9-12-23(27)26(5,16-14-24(28)29)22(19)13-15-25(20,21)4/h17-22H,6-16H2,1-5H3,(H,28,29)/t18?,19?,20?,21?,22?,25-,26-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067827
((S)-2-[(3aR,6R,9S)-3-(1,5-Dimethyl-hexyl)-9-ethyl-...)Show SMILES CCOC(=O)C[C@H](C[C@]1(C)C2CC[C@]3(C)C(CCC3C2[C@@H](CC)CC1=O)C(C)CCCC(C)C)C(O)=O Show InChI InChI=1S/C32H54O5/c1-8-22-17-27(33)32(7,19-23(30(35)36)18-28(34)37-9-2)26-15-16-31(6)24(13-14-25(31)29(22)26)21(5)12-10-11-20(3)4/h20-26,29H,8-19H2,1-7H3,(H,35,36)/t21?,22-,23+,24?,25?,26?,29?,31+,32+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067823
(CHEMBL138048 | Isobutyric acid 2-[(3aS,6R)-6-(2-ca...)Show SMILES CC(C)C(=O)OCC(=O)C1CCC2C3CCC(=O)[C@](C)(CCC(O)=O)C3C(=O)C[C@]12C Show InChI InChI=1S/C24H34O7/c1-13(2)22(30)31-12-18(26)16-7-6-15-14-5-8-19(27)23(3,10-9-20(28)29)21(14)17(25)11-24(15,16)4/h13-16,21H,5-12H2,1-4H3,(H,28,29)/t14?,15?,16?,21?,23-,24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067820
(3-[(3aR,6R,9S)-3-(1,5-Dimethyl-hexyl)-9-ethyl-3a,6...)Show SMILES CC[C@H]1CC(=O)[C@](C)(CCC(O)=O)C2CC[C@]3(C)C(CCC3C12)C(C)CCCC(C)C Show InChI InChI=1S/C28H48O3/c1-7-20-17-24(29)28(6,16-14-25(30)31)23-13-15-27(5)21(11-12-22(27)26(20)23)19(4)10-8-9-18(2)3/h18-23,26H,7-17H2,1-6H3,(H,30,31)/t19?,20-,21?,22?,23?,26?,27+,28+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067836
((S)-2-[(3aR,6R)-3-(1,5-Dimethyl-hexyl)-3a,6-dimeth...)Show SMILES CCOC(=O)C[C@H](C[C@]1(C)C2CC[C@]3(C)C(CCC3C2CCC1=O)C(C)CCCC(C)C)C(O)=O Show InChI InChI=1S/C30H50O5/c1-7-35-27(32)17-21(28(33)34)18-30(6)25-15-16-29(5)23(20(4)10-8-9-19(2)3)12-13-24(29)22(25)11-14-26(30)31/h19-25H,7-18H2,1-6H3,(H,33,34)/t20?,21-,22?,23?,24?,25?,29-,30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067832
(3a,6-dimethyl-5,7-dioxo-(3'R,3aS,6R)-dispiro[perhy...)Show SMILES C[C@]12CC(=O)C3C(CCC(=O)[C@]3(C)C(O)=O)C1CC[C@@]21OCOC11COCO1 Show InChI InChI=1S/C20H26O8/c1-17-7-13(21)15-11(3-4-14(22)18(15,2)16(23)24)12(17)5-6-19(17)20(28-10-26-19)8-25-9-27-20/h11-12,15H,3-10H2,1-2H3,(H,23,24)/t11?,12?,15?,17-,18-,19+,20?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067824
(3-((3aS,6R)-3-Acetyl-3a,6-dimethyl-5,7-dioxo-dodec...)Show SMILES CC(=O)C1CCC2C3CCC(=O)[C@](C)(CCC(O)=O)C3C(=O)C[C@]12C Show InChI InChI=1S/C20H28O5/c1-11(21)13-5-6-14-12-4-7-16(23)19(2,9-8-17(24)25)18(12)15(22)10-20(13,14)3/h12-14,18H,4-10H2,1-3H3,(H,24,25)/t12?,13?,14?,18?,19-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Farnesyltransferase |
J Med Chem 41: 4492-501 (1998)
Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ |
More data for this
Ligand-Target Pair | |
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