Compile Data Set for Download or QSAR

Found 73 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 7328   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111821 (US8623906, XW2-038H | US9174969, JHE-02-023) Show SMILES OC(=O)CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H24ClN3O5S/c23-17-2-1-3-18(15-17)24-10-12-25(13-11-24)32(30,31)19-4-5-20-16(14-19)8-9-26(20)21(27)6-7-22(28)29/h1-5,14-15H,6-13H2,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) Show SMILES OC(CC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C22H24ClN3O6S/c23-16-2-1-3-17(13-16)24-8-10-25(11-9-24)33(31,32)18-4-5-19-15(12-18)6-7-26(19)21(28)14-20(27)22(29)30/h1-5,12-13,20,27H,6-11,14H2,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) Show SMILES OC(CC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C22H24ClN3O6S/c23-16-2-1-3-17(13-16)24-8-10-25(11-9-24)33(31,32)18-4-5-19-15(12-18)6-7-26(19)21(28)14-20(27)22(29)30/h1-5,12-13,20,27H,6-11,14H2,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111822 (US8623906, XW2-125B | US9174969, XW2-125B) Show SMILES Cc1ccc(Cl)cc1N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)CCC(O)=O Show InChI InChI=1S/C23H26ClN3O5S/c1-16-2-3-18(24)15-21(16)25-10-12-26(13-11-25)33(31,32)19-4-5-20-17(14-19)8-9-27(20)22(28)6-7-23(29)30/h2-5,14-15H,6-13H2,1H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM189410 (US9174969, CDL 4340-0580) Show SMILES CCOc1ccc(NC(=O)CN2C(=O)\C(=C3/SC(=S)C(CCS([O-])(=O)=O)C3=O)c3ccccc23)cc1 Show InChI InChI=1S/C24H22N2O7S3/c1-2-33-15-9-7-14(8-10-15)25-19(27)13-26-18-6-4-3-5-16(18)20(23(26)29)22-21(28)17(24(34)35-22)11-12-36(30,31)32/h3-10,17H,2,11-13H2,1H3,(H,25,27)(H,30,31,32)/p-1/b22-20-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM189411 (US9174969, NAT6-297775) Show SMILES C(NC1COC2C1OC[C@@H]2n1nnnc1-c1cccc(CN2CCCC2)c1)C1CCCCC1 |r| Show InChI InChI=1S/C25H36N6O2/c1-2-7-18(8-3-1)14-26-21-16-32-24-22(17-33-23(21)24)31-25(27-28-29-31)20-10-6-9-19(13-20)15-30-11-4-5-12-30/h6,9-10,13,18,21-24,26H,1-5,7-8,11-12,14-17H2/t21?,22-,23?,24?/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111824 (US8623906, JHE-02-119 | US9174969, JHE-02-119) Show SMILES CC1Cc2cc(ccc2N1C(=O)CCC(O)=O)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C23H26ClN3O5S/c1-16-13-17-14-20(5-6-21(17)27(16)22(28)7-8-23(29)30)33(31,32)26-11-9-25(10-12-26)19-4-2-3-18(24)15-19/h2-6,14-16H,7-13H2,1H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM189409 (US9174969, JHE-01-129A) Show SMILES OC(=O)\C=C/C(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H22ClN3O5S/c23-17-2-1-3-18(15-17)24-10-12-25(13-11-24)32(30,31)19-4-5-20-16(14-19)8-9-26(20)21(27)6-7-22(28)29/h1-7,14-15H,8-13H2,(H,28,29)/b7-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111832 (US8623906, JHE-01-129B | US9174969, JHE-01-129B) Show SMILES OC(=O)CCCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C23H26ClN3O5S/c24-18-3-1-4-19(16-18)25-11-13-26(14-12-25)33(31,32)20-7-8-21-17(15-20)9-10-27(21)22(28)5-2-6-23(29)30/h1,3-4,7-8,15-16H,2,5-6,9-14H2,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111873 (US8623906, JHE-02-020B | US9174969, JHE-02-020B) Show SMILES OC(=O)c1cccc(NC(=O)N2CCc3cc(ccc23)S(=O)(=O)N2CCN(CC2)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C26H25ClN4O5S/c27-20-4-2-6-22(17-20)29-11-13-30(14-12-29)37(35,36)23-7-8-24-18(16-23)9-10-31(24)26(34)28-21-5-1-3-19(15-21)25(32)33/h1-8,15-17H,9-14H2,(H,28,34)(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111828 (US8623906, JHE-02-065B | US9174969, JHE-02-065B) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)Nc1ccccc1Cl Show InChI InChI=1S/C25H24Cl2N4O3S/c26-19-4-3-5-20(17-19)29-12-14-30(15-13-29)35(33,34)21-8-9-24-18(16-21)10-11-31(24)25(32)28-23-7-2-1-6-22(23)27/h1-9,16-17H,10-15H2,(H,28,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111844 (US8623906, XW2-057 | US9174969, XW2-057) Show SMILES CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(C)c1 Show InChI InChI=1S/C22H27N3O3S/c1-3-22(26)25-10-9-18-16-20(7-8-21(18)25)29(27,28)24-13-11-23(12-14-24)19-6-4-5-17(2)15-19/h4-8,15-16H,3,9-14H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111829 (US8623906, JHE-02-068B | US9174969, JHE-02-068B) Show SMILES CC(C)c1ccc(NC(=O)N2CCc3cc(ccc23)S(=O)(=O)N2CCN(CC2)c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C28H31ClN4O3S/c1-20(2)21-6-8-24(9-7-21)30-28(34)33-13-12-22-18-26(10-11-27(22)33)37(35,36)32-16-14-31(15-17-32)25-5-3-4-23(29)19-25/h3-11,18-20H,12-17H2,1-2H3,(H,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111854 (US8623906, JHE-02-017C | US9174969, JHE-02-017C) Show SMILES CC(C)C(NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C24H29ClN4O5S/c1-16(2)22(23(30)31)26-24(32)29-9-8-17-14-20(6-7-21(17)29)35(33,34)28-12-10-27(11-13-28)19-5-3-4-18(25)15-19/h3-7,14-16,22H,8-13H2,1-2H3,(H,26,32)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111845 (US8623906, XW2-124B | US9174969, XW2-124B) Show SMILES OC(=O)CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C22H23Cl2N3O5S/c23-16-12-17(24)14-18(13-16)25-7-9-26(10-8-25)33(31,32)19-1-2-20-15(11-19)5-6-27(20)21(28)3-4-22(29)30/h1-2,11-14H,3-10H2,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111865 (US8623906, JHE-02-019A | US9174969, JHE-02-019A) Show SMILES CC(C)CC(NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C25H31ClN4O5S/c1-17(2)14-22(24(31)32)27-25(33)30-9-8-18-15-21(6-7-23(18)30)36(34,35)29-12-10-28(11-13-29)20-5-3-4-19(26)16-20/h3-7,15-17,22H,8-14H2,1-2H3,(H,27,33)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111837 (US8623906, JHE-01-137 | US9174969, JHE-01-137) Show SMILES OC(=O)CNC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H23ClN4O5S/c22-16-2-1-3-17(13-16)24-8-10-25(11-9-24)32(30,31)18-4-5-19-15(12-18)6-7-26(19)21(29)23-14-20(27)28/h1-5,12-13H,6-11,14H2,(H,23,29)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111851 (US8623906, XW2-036 | US9174969, XW2-036) Show SMILES OC(=O)CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C22H23Cl2N3O5S/c23-18-3-1-16(14-19(18)24)25-9-11-26(12-10-25)33(31,32)17-2-4-20-15(13-17)7-8-27(20)21(28)5-6-22(29)30/h1-4,13-14H,5-12H2,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111867 (US8623906, XW2-038F | US9174969, XW2-038F) Show SMILES COc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)CCC(O)=O Show InChI InChI=1S/C23H27N3O6S/c1-32-19-4-2-3-18(16-19)24-11-13-25(14-12-24)33(30,31)20-5-6-21-17(15-20)9-10-26(21)22(27)7-8-23(28)29/h2-6,15-16H,7-14H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111863 (US8623906, JHE-02-017A | US9174969, JHE-02-017A) Show SMILES OC(=O)CCNC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H25ClN4O5S/c23-17-2-1-3-18(15-17)25-10-12-26(13-11-25)33(31,32)19-4-5-20-16(14-19)7-9-27(20)22(30)24-8-6-21(28)29/h1-5,14-15H,6-13H2,(H,24,30)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111860 (US8623906, JHE-01-155B | US9174969, JHE-01-155B) Show SMILES OC(=O)C(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C20H20ClN3O5S/c21-15-2-1-3-16(13-15)22-8-10-23(11-9-22)30(28,29)17-4-5-18-14(12-17)6-7-24(18)19(25)20(26)27/h1-5,12-13H,6-11H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111858 (US8623906, JHE-02-010B | US9174969, JHE-02-010B) Show SMILES CCOC(=O)C(C)NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C24H29ClN4O5S/c1-3-34-23(30)17(2)26-24(31)29-10-9-18-15-21(7-8-22(18)29)35(32,33)28-13-11-27(12-14-28)20-6-4-5-19(25)16-20/h4-8,15-17H,3,9-14H2,1-2H3,(H,26,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111878 (US8623906, JHE-02-019B | US9174969, JHE-02-019B) Show SMILES OC(=O)C(Cc1ccccc1)NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C28H29ClN4O5S/c29-22-7-4-8-23(19-22)31-13-15-32(16-14-31)39(37,38)24-9-10-26-21(18-24)11-12-33(26)28(36)30-25(27(34)35)17-20-5-2-1-3-6-20/h1-10,18-19,25H,11-17H2,(H,30,36)(H,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111831 (US8623906, JHE-02-068A | US9174969, JHE-02-068A) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)Nc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C25H23Cl3N4O3S/c26-18-2-1-3-20(15-18)30-10-12-31(13-11-30)36(34,35)21-5-7-24-17(14-21)8-9-32(24)25(33)29-19-4-6-22(27)23(28)16-19/h1-7,14-16H,8-13H2,(H,29,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111836 (US8623906, JF020 | US9174969, JF020) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C25H23Cl2N3O3S/c26-20-4-1-3-19(15-20)25(31)30-10-9-18-16-23(7-8-24(18)30)34(32,33)29-13-11-28(12-14-29)22-6-2-5-21(27)17-22/h1-8,15-17H,9-14H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111850 (US8623906, JHE-02-012 | US9174969, JHE-02-012) Show SMILES CCOC(=O)C(CC(C)C)NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C27H35ClN4O5S/c1-4-37-26(33)24(16-19(2)3)29-27(34)32-11-10-20-17-23(8-9-25(20)32)38(35,36)31-14-12-30(13-15-31)22-7-5-6-21(28)18-22/h5-9,17-19,24H,4,10-16H2,1-3H3,(H,29,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111830 (US8623906, XW2-038A | US8623906, XW3-002 | US91749...) Show SMILES OC(=O)CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1ccccc1 Show InChI InChI=1S/C22H25N3O5S/c26-21(8-9-22(27)28)25-11-10-17-16-19(6-7-20(17)25)31(29,30)24-14-12-23(13-15-24)18-4-2-1-3-5-18/h1-7,16H,8-15H2,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111833 (US8623906, JF028 | US9174969, JF028) Show SMILES COc1ccc(cc1)C(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C26H26ClN3O4S/c1-34-23-7-5-19(6-8-23)26(31)30-12-11-20-17-24(9-10-25(20)30)35(32,33)29-15-13-28(14-16-29)22-4-2-3-21(27)18-22/h2-10,17-18H,11-16H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111847 (US8623906, JHE-02-017B | US9174969, JHE-02-017B) Show SMILES CC(NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C22H25ClN4O5S/c1-15(21(28)29)24-22(30)27-8-7-16-13-19(5-6-20(16)27)33(31,32)26-11-9-25(10-12-26)18-4-2-3-17(23)14-18/h2-6,13-15H,7-12H2,1H3,(H,24,30)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111870 (US8623906, JHE-02-014 | US9174969, JHE-02-014) Show SMILES CCOC(=O)C(Cc1ccccc1)NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C30H33ClN4O5S/c1-2-40-29(36)27(19-22-7-4-3-5-8-22)32-30(37)35-14-13-23-20-26(11-12-28(23)35)41(38,39)34-17-15-33(16-18-34)25-10-6-9-24(31)21-25/h3-12,20-21,27H,2,13-19H2,1H3,(H,32,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111835 (US8623906, JF026 | US9174969, JF026) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)C1CCCC1 Show InChI InChI=1S/C24H28ClN3O3S/c25-20-6-3-7-21(17-20)26-12-14-27(15-13-26)32(30,31)22-8-9-23-19(16-22)10-11-28(23)24(29)18-4-1-2-5-18/h3,6-9,16-18H,1-2,4-5,10-15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111855 (US8623906, JF023 | US9174969, JF023) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C25H22Cl3N3O3S/c26-19-2-1-3-20(16-19)29-10-12-30(13-11-29)35(33,34)21-5-7-24-17(14-21)8-9-31(24)25(32)18-4-6-22(27)23(28)15-18/h1-7,14-16H,8-13H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111843 (US8623906, JF024 | US9174969, JF024) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C25H22Cl3N3O3S/c26-18-2-1-3-20(15-18)29-10-12-30(13-11-29)35(33,34)21-5-7-24-17(14-21)8-9-31(24)25(32)22-6-4-19(27)16-23(22)28/h1-7,14-16H,8-13H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111864 (US8623906, JHE-02-010C | US9174969, JHE-02-010C) Show SMILES CCOC(=O)C(NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1)C(C)C Show InChI InChI=1S/C26H33ClN4O5S/c1-4-36-25(32)24(18(2)3)28-26(33)31-11-10-19-16-22(8-9-23(19)31)37(34,35)30-14-12-29(13-15-30)21-7-5-6-20(27)17-21/h5-9,16-18,24H,4,10-15H2,1-3H3,(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111862 (US8623906, JHE-02-033A | US9174969, JHE-02-033A) Show SMILES CCCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C22H26ClN3O3S/c1-2-4-22(27)26-10-9-17-15-20(7-8-21(17)26)30(28,29)25-13-11-24(12-14-25)19-6-3-5-18(23)16-19/h3,5-8,15-16H,2,4,9-14H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111842 (US8623906, JHE-02-063B | US9174969, JHE-02-063B) Show SMILES Clc1ccc(CC(=O)N2CCc3cc(ccc23)S(=O)(=O)N2CCN(CC2)c2cccc(Cl)c2)cc1 Show InChI InChI=1S/C26H25Cl2N3O3S/c27-21-6-4-19(5-7-21)16-26(32)31-11-10-20-17-24(8-9-25(20)31)35(33,34)30-14-12-29(13-15-30)23-3-1-2-22(28)18-23/h1-9,17-18H,10-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111856 (US8623906, JF039 | US9174969, JF039) Show SMILES Fc1cccc(NC(=O)N2CCc3cc(ccc23)S(=O)(=O)N2CCN(CC2)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C25H24ClFN4O3S/c26-19-3-1-6-22(16-19)29-11-13-30(14-12-29)35(33,34)23-7-8-24-18(15-23)9-10-31(24)25(32)28-21-5-2-4-20(27)17-21/h1-8,15-17H,9-14H2,(H,28,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111852 (US8623906, JHE-02-035A | US9174969, JHE-02-035A) Show SMILES COc1cccc(c1)C(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C26H26ClN3O4S/c1-34-23-7-2-4-20(16-23)26(31)30-11-10-19-17-24(8-9-25(19)30)35(32,33)29-14-12-28(13-15-29)22-6-3-5-21(27)18-22/h2-9,16-18H,10-15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) Show SMILES OC(CC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C22H24ClN3O6S/c23-16-2-1-3-17(13-16)24-8-10-25(11-9-24)33(31,32)18-4-5-19-15(12-18)6-7-26(19)21(28)14-20(27)22(29)30/h1-5,12-13,20,27H,6-11,14H2,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111841 (US8623906, JF025 | US9174969, JF025) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C25H22Cl3N3O3S/c26-19-2-1-3-22(16-19)29-8-10-30(11-9-29)35(33,34)23-4-5-24-17(14-23)6-7-31(24)25(32)18-12-20(27)15-21(28)13-18/h1-5,12-16H,6-11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111875 (US8623906, JHE-02-020A | US9174969, JHE-02-020A) Show SMILES OC(=O)c1ccccc1NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C26H25ClN4O5S/c27-19-4-3-5-20(17-19)29-12-14-30(15-13-29)37(35,36)21-8-9-24-18(16-21)10-11-31(24)26(34)28-23-7-2-1-6-22(23)25(32)33/h1-9,16-17H,10-15H2,(H,28,34)(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111827 (US8623906, JHE-02-032A | US9174969, JHE-02-032A) Show SMILES Clc1cccc(NC(=O)N2CCc3cc(ccc23)S(=O)(=O)N2CCN(CC2)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C25H24Cl2N4O3S/c26-19-3-1-5-21(16-19)28-25(32)31-10-9-18-15-23(7-8-24(18)31)35(33,34)30-13-11-29(12-14-30)22-6-2-4-20(27)17-22/h1-8,15-17H,9-14H2,(H,28,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111853 (US8623906, JF022 | US9174969, JF022) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)c1ccccc1 Show InChI InChI=1S/C25H24ClN3O3S/c26-21-7-4-8-22(18-21)27-13-15-28(16-14-27)33(31,32)23-9-10-24-20(17-23)11-12-29(24)25(30)19-5-2-1-3-6-19/h1-10,17-18H,11-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111848 (US8623906, JF027 | US9174969, JF027) Show SMILES Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)C1CC1 Show InChI InChI=1S/C22H24ClN3O3S/c23-18-2-1-3-19(15-18)24-10-12-25(13-11-24)30(28,29)20-6-7-21-17(14-20)8-9-26(21)22(27)16-4-5-16/h1-3,6-7,14-16H,4-5,8-13H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111859 (US8623906, JF040 | US9174969, JF040) Show SMILES FC(F)(F)c1ccccc1NC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C26H24ClF3N4O3S/c27-19-4-3-5-20(17-19)32-12-14-33(15-13-32)38(36,37)21-8-9-24-18(16-21)10-11-34(24)25(35)31-23-7-2-1-6-22(23)26(28,29)30/h1-9,16-17H,10-15H2,(H,31,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111877 (US8623906, XW2-038E | US9174969, XW2-038E) Show SMILES COc1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)CCC(O)=O Show InChI InChI=1S/C23H27N3O6S/c1-32-19-4-2-18(3-5-19)24-12-14-25(15-13-24)33(30,31)20-6-7-21-17(16-20)10-11-26(21)22(27)8-9-23(28)29/h2-7,16H,8-15H2,1H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111849 (US8623906, XW2-119 | US9174969, XW2-119) Show SMILES OC(=O)CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C24H23F6N3O5S/c25-23(26,27)16-12-17(24(28,29)30)14-18(13-16)31-7-9-32(10-8-31)39(37,38)19-1-2-20-15(11-19)5-6-33(20)21(34)3-4-22(35)36/h1-2,11-14H,3-10H2,(H,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111869 (US8623906, JHE-02-010A | US9174969, JHE-02-010A) Show SMILES CCOC(=O)CCNC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C24H29ClN4O5S/c1-2-34-23(30)8-10-26-24(31)29-11-9-18-16-21(6-7-22(18)29)35(32,33)28-14-12-27(13-15-28)20-5-3-4-19(25)17-20/h3-7,16-17H,2,8-15H2,1H3,(H,26,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111881 (US8623906, JHE-01-169 | US9174969, JHE-01-169) Show SMILES COCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C21H24ClN3O4S/c1-29-15-21(26)25-8-7-16-13-19(5-6-20(16)25)30(27,28)24-11-9-23(10-12-24)18-4-2-3-17(22)14-18/h2-6,13-14H,7-12,15H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM111840 (US8623906, JHE-02-032B | US9174969, JHE-02-032B) Show SMILES COc1cccc(NC(=O)N2CCc3cc(ccc23)S(=O)(=O)N2CCN(CC2)c2cccc(Cl)c2)c1 Show InChI InChI=1S/C26H27ClN4O4S/c1-35-23-7-3-5-21(18-23)28-26(32)31-11-10-19-16-24(8-9-25(19)31)36(33,34)30-14-12-29(13-15-30)22-6-2-4-20(27)17-22/h2-9,16-18H,10-15H2,1H3,(H,28,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
UNIVERSITY OF SOUTH FLORIDA US Patent					Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay.				US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65
					More data for this Ligand-Target Pair

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