Compile Data Set for Download or QSAR

Found 794 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 9195   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400309 (US10695337, Example 63 | US11285140, Example 63 | ...) Show SMILES Fc1cc(ccc1Cl)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H24ClFN8O/c27-21-2-1-17(11-22(21)28)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-18(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400310 (US10695337, Example 64 | US11285140, Example 64 | ...) Show SMILES Cc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C27H27FN8O/c1-18-2-3-19(12-23(18)28)26(37)34-10-5-21(6-11-34)35-15-27(16-35,7-8-29)36-14-20(13-33-36)24-22-4-9-30-25(22)32-17-31-24/h2-4,9,12-14,17,21H,5-7,10-11,15-16H2,1H3,(H,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400311 (US10695337, Example 65 | US11285140, Example 65 | ...) Show SMILES Cc1cc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(C)o1 Show InChI InChI=1S/C26H28N8O2/c1-17-11-22(18(2)36-17)25(35)32-9-4-20(5-10-32)33-14-26(15-33,6-7-27)34-13-19(12-31-34)23-21-3-8-28-24(21)30-16-29-23/h3,8,11-13,16,20H,4-6,9-10,14-15H2,1-2H3,(H,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400313 (US10695337, Example 67 | US11285140, Example 67 | ...) Show SMILES Fc1ccccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H25FN8O/c27-22-4-2-1-3-20(22)25(36)33-11-6-19(7-12-33)34-15-26(16-34,8-9-28)35-14-18(13-32-35)23-21-5-10-29-24(21)31-17-30-23/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400316 (US10695337, Example 70 | US11285140, Example 70 | ...) Show SMILES COc1cc(sc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F Show InChI InChI=1S/C26H25F3N8O2S/c1-39-19-10-20(26(27,28)29)40-22(19)24(38)35-8-3-17(4-9-35)36-13-25(14-36,5-6-30)37-12-16(11-34-37)21-18-2-7-31-23(18)33-15-32-21/h2,7,10-12,15,17H,3-5,8-9,13-14H2,1H3,(H,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM448506 (US10695337, Example 72 | US11285140, Example 72 | ...) Show SMILES COc1cscc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C25H26N8O2S/c1-35-21-13-36-12-20(21)24(34)31-8-3-18(4-9-31)32-14-25(15-32,5-6-26)33-11-17(10-30-33)22-19-2-7-27-23(19)29-16-28-22/h2,7,10-13,16,18H,3-5,8-9,14-15H2,1H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400319 (US10695337, Example 73 | US11285140, Example 73 | ...) Show SMILES Cc1cc(cs1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C25H26N8OS/c1-17-10-18(13-35-17)24(34)31-8-3-20(4-9-31)32-14-25(15-32,5-6-26)33-12-19(11-30-33)22-21-2-7-27-23(21)29-16-28-22/h2,7,10-13,16,20H,3-5,8-9,14-15H2,1H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400320 (US10695337, Example 74 | US11285140, Example 74 | ...) Show SMILES COc1c(Cl)scc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C25H25ClN8O2S/c1-36-21-19(12-37-22(21)26)24(35)32-8-3-17(4-9-32)33-13-25(14-33,5-6-27)34-11-16(10-31-34)20-18-2-7-28-23(18)30-15-29-20/h2,7,10-12,15,17H,3-5,8-9,13-14H2,1H3,(H,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400321 (US10695337, Example 75 | US11285140, Example 75 | ...) Show SMILES Brc1sccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C24H23BrN8OS/c25-21-19(4-10-35-21)23(34)31-8-2-17(3-9-31)32-13-24(14-32,5-6-26)33-12-16(11-30-33)20-18-1-7-27-22(18)29-15-28-20/h1,4,7,10-12,15,17H,2-3,5,8-9,13-14H2,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400322 (US10695337, Example 76 | US11285140, Example 76 | ...) Show SMILES Clc1ccsc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C24H23ClN8OS/c25-19-4-10-35-21(19)23(34)31-8-2-17(3-9-31)32-13-24(14-32,5-6-26)33-12-16(11-30-33)20-18-1-7-27-22(18)29-15-28-20/h1,4,7,10-12,15,17H,2-3,5,8-9,13-14H2,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400323 (US10695337, Example 77 | US11285140, Example 77 | ...) Show SMILES Clc1ccc(s1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C24H23ClN8OS/c25-20-2-1-19(35-20)23(34)31-9-4-17(5-10-31)32-13-24(14-32,6-7-26)33-12-16(11-30-33)21-18-3-8-27-22(18)29-15-28-21/h1-3,8,11-12,15,17H,4-6,9-10,13-14H2,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400324 (US10695337, Example 78 | US11285140, Example 78 | ...) Show SMILES Cc1ccsc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C25H26N8OS/c1-17-5-11-35-22(17)24(34)31-9-3-19(4-10-31)32-14-25(15-32,6-7-26)33-13-18(12-30-33)21-20-2-8-27-23(20)29-16-28-21/h2,5,8,11-13,16,19H,3-4,6,9-10,14-15H2,1H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400325 (US10695337, Example 79 | US9999619, Example 80) Show SMILES Cc1csc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C25H26N8OS/c1-17-10-21(35-13-17)24(34)31-8-3-19(4-9-31)32-14-25(15-32,5-6-26)33-12-18(11-30-33)22-20-2-7-27-23(20)29-16-28-22/h2,7,10-13,16,19H,3-5,8-9,14-15H2,1H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400326 (US10695337, Example 80 | US11285140, Example 80 | ...) Show SMILES Cc1ccc(s1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C25H26N8OS/c1-17-2-3-21(35-17)24(34)31-10-5-19(6-11-31)32-14-25(15-32,7-8-26)33-13-18(12-30-33)22-20-4-9-27-23(20)29-16-28-22/h2-4,9,12-13,16,19H,5-7,10-11,14-15H2,1H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400327 (US10695337, Example 81 | US11285140, Example 81 | ...) Show SMILES COc1ccsc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C25H26N8O2S/c1-35-20-5-11-36-22(20)24(34)31-9-3-18(4-10-31)32-14-25(15-32,6-7-26)33-13-17(12-30-33)21-19-2-8-27-23(19)29-16-28-21/h2,5,8,11-13,16,18H,3-4,6,9-10,14-15H2,1H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400328 (US10695337, Example 82 | US11285140, Example 82 | ...) Show SMILES Fc1cc(ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F Show InChI InChI=1S/C27H24F4N8O/c28-22-11-18(27(29,30)31)1-2-20(22)25(40)37-9-4-19(5-10-37)38-14-26(15-38,6-7-32)39-13-17(12-36-39)23-21-3-8-33-24(21)35-16-34-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,33,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400329 (US10695337, Example 83 | US11285140, Example 83 | ...) Show SMILES Fc1cc(cc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N Show InChI InChI=1S/C27H23F2N9O/c28-21-9-17(11-31)10-22(29)23(21)26(39)36-7-2-19(3-8-36)37-14-27(15-37,4-5-30)38-13-18(12-35-38)24-20-1-6-32-25(20)34-16-33-24/h1,6,9-10,12-13,16,19H,2-4,7-8,14-15H2,(H,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400330 (US10695337, Example 84 | US11285140, Example 84 | ...) Show SMILES Oc1ccc(cc1Cl)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C26H25ClN8O2/c27-21-11-17(1-2-22(21)36)25(37)33-9-4-19(5-10-33)34-14-26(15-34,6-7-28)35-13-18(12-32-35)23-20-3-8-29-24(20)31-16-30-23/h1-3,8,11-13,16,19,36H,4-6,9-10,14-15H2,(H,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400332 (US10695337, Example 86 | US11285140, Example 86 | ...) Show SMILES FC(F)(F)c1cncc(n1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C25H23F3N10O/c26-25(27,28)20-11-30-10-19(35-20)23(39)36-7-2-17(3-8-36)37-13-24(14-37,4-5-29)38-12-16(9-34-38)21-18-1-6-31-22(18)33-15-32-21/h1,6,9-12,15,17H,2-4,7-8,13-14H2,(H,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400333 (US10695337, Example 87 | US11285140, Example 87 | ...) Show SMILES O=C(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1cccc2ccccc12 Show InChI InChI=1S/C30H28N8O/c31-12-11-30(38-17-22(16-35-38)27-26-8-13-32-28(26)34-20-33-27)18-37(19-30)23-9-14-36(15-10-23)29(39)25-7-3-5-21-4-1-2-6-24(21)25/h1-8,13,16-17,20,23H,9-11,14-15,18-19H2,(H,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400335 (US10695337, Example 89 | US11285140, Example 89 | ...) Show SMILES O=C(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1ccc2ncccc2c1 Show InChI InChI=1S/C29H27N9O/c30-9-8-29(38-16-22(15-35-38)26-24-5-11-32-27(24)34-19-33-26)17-37(18-29)23-6-12-36(13-7-23)28(39)21-3-4-25-20(14-21)2-1-10-31-25/h1-5,10-11,14-16,19,23H,6-8,12-13,17-18H2,(H,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400336 (US10695337, Example 90 | US11285140, Example 90 | ...) Show SMILES O=C(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1cc2ccccc2s1 Show InChI InChI=1S/C28H26N8OS/c29-9-8-28(36-15-20(14-33-36)25-22-5-10-30-26(22)32-18-31-25)16-35(17-28)21-6-11-34(12-7-21)27(37)24-13-19-3-1-2-4-23(19)38-24/h1-5,10,13-15,18,21H,6-8,11-12,16-17H2,(H,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400337 (US10695337, Example 91 | US11285140, Example 91 | ...) Show SMILES Fc1ccc2c(Cl)c(sc2c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C28H24ClFN8OS/c29-23-20-2-1-18(30)11-22(20)40-25(23)27(39)36-9-4-19(5-10-36)37-14-28(15-37,6-7-31)38-13-17(12-35-38)24-21-3-8-32-26(21)34-16-33-24/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400338 (US10695337, Example 92 | US11285140, Example 92 | ...) Show SMILES Fc1cccc2sc(C(=O)N3CCC(CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)c(Cl)c12 Show InChI InChI=1S/C28H24ClFN8OS/c29-23-22-20(30)2-1-3-21(22)40-25(23)27(39)36-10-5-18(6-11-36)37-14-28(15-37,7-8-31)38-13-17(12-35-38)24-19-4-9-32-26(19)34-16-33-24/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400339 (US10695337, Example 93 | US11285140, Example 93 | ...) Show SMILES FC(F)(F)c1cccc2sc(cc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C29H25F3N8OS/c30-29(31,32)22-2-1-3-23-21(22)12-24(42-23)27(41)38-10-5-19(6-11-38)39-15-28(16-39,7-8-33)40-14-18(13-37-40)25-20-4-9-34-26(20)36-17-35-25/h1-4,9,12-14,17,19H,5-7,10-11,15-16H2,(H,34,35,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400341 (US10695337, Example 95 | US11285140, Example 95 | ...) Show SMILES FC(F)(F)c1cccc2cc(sc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C29H25F3N8OS/c30-29(31,32)22-3-1-2-18-12-23(42-25(18)22)27(41)38-10-5-20(6-11-38)39-15-28(16-39,7-8-33)40-14-19(13-37-40)24-21-4-9-34-26(21)36-17-35-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,34,35,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400342 (US10695337, Example 96 | US11285140, Example 96 | ...) Show SMILES O=C(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1csc2ccccc12 Show InChI InChI=1S/C28H26N8OS/c29-9-8-28(36-14-19(13-33-36)25-22-5-10-30-26(22)32-18-31-25)16-35(17-28)20-6-11-34(12-7-20)27(37)23-15-38-24-4-2-1-3-21(23)24/h1-5,10,13-15,18,20H,6-8,11-12,16-17H2,(H,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400361 (US10695337, Example 115 | US11285140, Example 115 ...) Show SMILES Fc1cc(ccc1-c1ccc2cnccc2c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-31-16-25(3-4-29(31)24-1-2-26-17-38-11-5-23(26)15-24)34(46)43-13-7-28(8-14-43)44-20-35(21-44,9-10-37)45-19-27(18-42-45)32-30-6-12-39-33(30)41-22-40-32/h1-6,11-12,15-19,22,28H,7-9,13-14,20-21H2,(H,39,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400362 (US10695337, Example 116 | US11285140, Example 116 ...) Show SMILES Fc1cc(cc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)-c1cccnc1 Show InChI InChI=1S/C31H27F2N9O/c32-25-12-21(20-2-1-8-35-14-20)13-26(33)27(25)30(43)40-10-4-23(5-11-40)41-17-31(18-41,6-7-34)42-16-22(15-39-42)28-24-3-9-36-29(24)38-19-37-28/h1-3,8-9,12-16,19,23H,4-6,10-11,17-18H2,(H,36,37,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400363 (US10695337, Example 117 | US11285140, Example 117 ...) Show SMILES Fc1cc(ccc1-c1ccncc1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C31H28FN9O/c32-27-15-22(1-2-25(27)21-3-10-34-11-4-21)30(42)39-13-6-24(7-14-39)40-18-31(19-40,8-9-33)41-17-23(16-38-41)28-26-5-12-35-29(26)37-20-36-28/h1-5,10-12,15-17,20,24H,6-8,13-14,18-19H2,(H,35,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400364 (US10695337, Example 118 | US11285140, Example 118 ...) Show SMILES Fc1cc(ccc1-c1ccc(cc1)C#N)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C33H28FN9O/c34-29-15-24(5-6-27(29)23-3-1-22(16-36)2-4-23)32(44)41-13-8-26(9-14-41)42-19-33(20-42,10-11-35)43-18-25(17-40-43)30-28-7-12-37-31(28)39-21-38-30/h1-7,12,15,17-18,21,26H,8-10,13-14,19-20H2,(H,37,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400365 (US10695337, Example 119 | US11285140, Example 119 ...) Show SMILES Fc1cc(ccc1C#N)-c1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C33H27F2N9O/c34-28-13-21(1-2-23(28)15-37)26-4-3-22(14-29(26)35)32(45)42-11-6-25(7-12-42)43-18-33(19-43,8-9-36)44-17-24(16-41-44)30-27-5-10-38-31(27)40-20-39-30/h1-5,10,13-14,16-17,20,25H,6-8,11-12,18-19H2,(H,38,39,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400366 (US10695337, Example 120 | US11285140, Example 120 ...) Show SMILES Fc1cc(ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)-c1cccnc1 Show InChI InChI=1S/C31H28FN9O/c32-27-14-21(22-2-1-10-34-15-22)3-4-25(27)30(42)39-12-6-24(7-13-39)40-18-31(19-40,8-9-33)41-17-23(16-38-41)28-26-5-11-35-29(26)37-20-36-28/h1-5,10-11,14-17,20,24H,6-8,12-13,18-19H2,(H,35,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400367 (US10695337, Example 121 | US11285140, Example 121 ...) Show SMILES Fc1ccc(cc1-c1nccs1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C29H26FN9OS/c30-24-2-1-19(13-23(24)27-33-9-12-41-27)28(40)37-10-4-21(5-11-37)38-16-29(17-38,6-7-31)39-15-20(14-36-39)25-22-3-8-32-26(22)35-18-34-25/h1-3,8-9,12-15,18,21H,4-6,10-11,16-17H2,(H,32,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400369 (US10695337, Example 123 | US11285140, Example 123 ...) Show SMILES Fc1cc(ccc1-c1cccnc1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C31H28FN9O/c32-27-14-21(3-4-25(27)22-2-1-10-34-15-22)30(42)39-12-6-24(7-13-39)40-18-31(19-40,8-9-33)41-17-23(16-38-41)28-26-5-11-35-29(26)37-20-36-28/h1-5,10-11,14-17,20,24H,6-8,12-13,18-19H2,(H,35,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400370 (US10695337, Example 124 | US11285140, Example 124 ...) Show SMILES Fc1cc(ccc1-c1ccccc1C#N)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C33H28FN9O/c34-29-15-22(5-6-27(29)26-4-2-1-3-23(26)16-36)32(44)41-13-8-25(9-14-41)42-19-33(20-42,10-11-35)43-18-24(17-40-43)30-28-7-12-37-31(28)39-21-38-30/h1-7,12,15,17-18,21,25H,8-10,13-14,19-20H2,(H,37,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400371 (US10695337, Example 125 | US11285140, Example 125 ...) Show SMILES Fc1cc(ccc1-c1cccc(c1)C#N)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C33H28FN9O/c34-29-15-24(4-5-27(29)23-3-1-2-22(14-23)16-36)32(44)41-12-7-26(8-13-41)42-19-33(20-42,9-10-35)43-18-25(17-40-43)30-28-6-11-37-31(28)39-21-38-30/h1-6,11,14-15,17-18,21,26H,7-9,12-13,19-20H2,(H,37,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400372 (US10695337, Example 126 | US11285140, Example 126 ...) Show SMILES O=C(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1ccc(cc1)-c1ccc(cc1)C#N Show InChI InChI=1S/C33H29N9O/c34-13-12-33(42-19-27(18-39-42)30-29-9-14-36-31(29)38-22-37-30)20-41(21-33)28-10-15-40(16-11-28)32(43)26-7-5-25(6-8-26)24-3-1-23(17-35)2-4-24/h1-9,14,18-19,22,28H,10-12,15-16,20-21H2,(H,36,37,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400374 (US10695337, Example 128 | US11285140, Example 128 ...) Show SMILES Fc1cc(cc(c1)-c1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N Show InChI InChI=1S/C33H27F2N9O/c34-25-12-21(15-37)11-23(13-25)27-2-1-22(14-29(27)35)32(45)42-9-4-26(5-10-42)43-18-33(19-43,6-7-36)44-17-24(16-41-44)30-28-3-8-38-31(28)40-20-39-30/h1-3,8,11-14,16-17,20,26H,4-6,9-10,18-19H2,(H,38,39,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400375 (US10695337, Example 129 | US11285140, Example 129 ...) Show SMILES Fc1cc(ccc1-c1cccc2ncccc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-30-17-23(6-7-27(30)26-3-1-5-31-28(26)4-2-13-38-31)34(46)43-15-9-25(10-16-43)44-20-35(21-44,11-12-37)45-19-24(18-42-45)32-29-8-14-39-33(29)41-22-40-32/h1-8,13-14,17-19,22,25H,9-11,15-16,20-21H2,(H,39,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM448564 (US10695337, Example 130 | US11285140, Example 130 ...) Show SMILES Fc1cc(ccc1-c1cccc2cnccc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-31-16-23(4-5-29(31)28-3-1-2-24-17-38-12-6-27(24)28)34(46)43-14-8-26(9-15-43)44-20-35(21-44,10-11-37)45-19-25(18-42-45)32-30-7-13-39-33(30)41-22-40-32/h1-7,12-13,16-19,22,26H,8-10,14-15,20-21H2,(H,39,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400377 (US10695337, Example 131 | US11285140, Example 131 ...) Show SMILES Fc1cc(ccc1-c1cccc2ccncc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-31-16-24(4-5-28(31)27-3-1-2-23-6-12-38-18-30(23)27)34(46)43-14-8-26(9-15-43)44-20-35(21-44,10-11-37)45-19-25(17-42-45)32-29-7-13-39-33(29)41-22-40-32/h1-7,12-13,16-19,22,26H,8-10,14-15,20-21H2,(H,39,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400378 (US10695337, Example 132 | US11285140, Example 132 ...) Show SMILES Fc1cc(ccc1-c1cccc2cccnc12)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-30-17-24(6-7-27(30)28-5-1-3-23-4-2-13-38-31(23)28)34(46)43-15-9-26(10-16-43)44-20-35(21-44,11-12-37)45-19-25(18-42-45)32-29-8-14-39-33(29)41-22-40-32/h1-8,13-14,17-19,22,26H,9-11,15-16,20-21H2,(H,39,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400379 (US10695337, Example 133 | US11285140, Example 133 ...) Show SMILES Fc1cc(ccc1-c1ccc2ccncc2c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-31-16-25(3-4-29(31)24-2-1-23-5-11-38-17-26(23)15-24)34(46)43-13-7-28(8-14-43)44-20-35(21-44,9-10-37)45-19-27(18-42-45)32-30-6-12-39-33(30)41-22-40-32/h1-6,11-12,15-19,22,28H,7-9,13-14,20-21H2,(H,39,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400380 (US10695337, Example 134 | US11285140, Example 134 ...) Show SMILES Fc1cc(ccc1-c1ccc2cccnc2c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C35H30FN9O/c36-30-16-25(5-6-28(30)24-4-3-23-2-1-12-38-31(23)17-24)34(46)43-14-8-27(9-15-43)44-20-35(21-44,10-11-37)45-19-26(18-42-45)32-29-7-13-39-33(29)41-22-40-32/h1-7,12-13,16-19,22,27H,8-10,14-15,20-21H2,(H,39,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400381 (US10695337, Example 135 | US11285140, Example 135 ...) Show SMILES Fc1cc(ccc1-c1ccc2nccn2c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C33H29FN10O/c34-28-15-22(1-3-26(28)23-2-4-29-36-11-14-42(29)17-23)32(45)41-12-6-25(7-13-41)43-19-33(20-43,8-9-35)44-18-24(16-40-44)30-27-5-10-37-31(27)39-21-38-30/h1-5,10-11,14-18,21,25H,6-8,12-13,19-20H2,(H,37,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400383 (3-[(3-{3-(Cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyri...) Show SMILES Fc1cc(cc(c1)C(=O)N1C2CCC1CC(C2)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C#N |THB:17:15:9:11.12| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400384 (US10695337, Example 139 | US11285140, Example 139 ...) Show SMILES Fc1ccc(cc1F)C(=O)N1C2CCC1CC(C2)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 |THB:18:16:10:12.13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400387 (US10695337, Example 141 | US11285140, Example 141 ...) Show SMILES Fc1cc(ccc1Cl)C(=O)N1C2CCC1CC(C2)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 |THB:18:16:10:12.13| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human))	BDBM400388 (US10695337, Example 142 | US11285140, Example 142 ...) Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1C2CCC1CC(C2)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 |THB:21:19:13:15.16| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...				US Patent US10695337 (2020) BindingDB Entry DOI: 10.7270/Q2R214DJ
					More data for this Ligand-Target Pair

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