Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM50032693![]() (CHEBI:66901 | Ivacaftor | Kalydeco | VX-770) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 236 | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Potentiation of human CFTR F508del mutant in human bronchial epithelial cells by Ussing chambers recording technique | J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |