BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 7 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 50005901   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polyphenol oxidase 2


(Agaricus bisporus (Common mushroom))
BDBM50495305
PNG
(CHEMBL3103544)
Show SMILES COc1ccc(CCC(=O)c2c3OC(Cc3c3OC(C)(C)C=Cc3c2O)C(C)(C)O)cc1 |c:22|
Show InChI InChI=1S/C26H30O6/c1-25(2)13-12-17-22(28)21(19(27)11-8-15-6-9-16(30-5)10-7-15)24-18(23(17)32-25)14-20(31-24)26(3,4)29/h6-7,9-10,12-13,20,28-29H,8,11,14H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.22E+3n/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 min...


Bioorg Med Chem 22: 1115-20 (2014)


Article DOI: 10.1016/j.bmc.2013.12.047
BindingDB Entry DOI: 10.7270/Q2222XQ8
More data for this
Ligand-Target Pair
Polyphenol oxidase 2


(Agaricus bisporus (Common mushroom))
BDBM50495309
PNG
(Flemichin D)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c2-[#8]-[#6@@H](-[#6]-[#6](=O)-c2c(-[#8])c2-[#6]=[#6]C([#6])([#6])[#8]-c12)-c1ccc(-[#8])cc1-[#8] |r,c:17|
Show InChI InChI=1S/C25H26O6/c1-13(2)5-7-17-23-16(9-10-25(3,4)31-23)22(29)21-19(28)12-20(30-24(17)21)15-8-6-14(26)11-18(15)27/h5-6,8-11,20,26-27,29H,7,12H2,1-4H3/t20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.48E+3n/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 min...


Bioorg Med Chem 22: 1115-20 (2014)


Article DOI: 10.1016/j.bmc.2013.12.047
BindingDB Entry DOI: 10.7270/Q2222XQ8
More data for this
Ligand-Target Pair
Polyphenol oxidase 2


(Agaricus bisporus (Common mushroom))
BDBM50495308
PNG
(CHEMBL3103546)
Show SMILES [#6]-[#8]-c1ccc(-[#6]-[#6]-[#6](=O)-c2c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c3-[#8]C([#6])([#6])[#6](-[#8])-[#6]-c3c2-[#8])cc1
Show InChI InChI=1S/C26H32O6/c1-15(2)6-12-18-23(29)22(20(27)13-9-16-7-10-17(31-5)11-8-16)24(30)19-14-21(28)26(3,4)32-25(18)19/h6-8,10-11,21,28-30H,9,12-14H2,1-5H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.95E+4n/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 min...


Bioorg Med Chem 22: 1115-20 (2014)


Article DOI: 10.1016/j.bmc.2013.12.047
BindingDB Entry DOI: 10.7270/Q2222XQ8
More data for this
Ligand-Target Pair
Polyphenol oxidase 2


(Agaricus bisporus (Common mushroom))
BDBM50495306
PNG
(khonklonginol H)
Show SMILES [#6]-[#8]-c1ccc(-[#6@@H]-2-[#6]-[#6](=O)-c3c(-[#8])c4-[#6]=[#6]C([#6])([#6])[#8]-c4c(-[#6]\[#6]=[#6](\[#6])-[#6])c3-[#8]-2)c(-[#8])c1 |r,c:14|
Show InChI InChI=1S/C26H28O6/c1-14(2)6-8-18-24-17(10-11-26(3,4)32-24)23(29)22-20(28)13-21(31-25(18)22)16-9-7-15(30-5)12-19(16)27/h6-7,9-12,21,27,29H,8,13H2,1-5H3/t21-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.04E+4n/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 min...


Bioorg Med Chem 22: 1115-20 (2014)


Article DOI: 10.1016/j.bmc.2013.12.047
BindingDB Entry DOI: 10.7270/Q2222XQ8
More data for this
Ligand-Target Pair
Polyphenol oxidase 2


(Agaricus bisporus (Common mushroom))
BDBM50495307
PNG
(CHEMBL3103545)
Show SMILES COc1ccc(CCC(=O)c2ccc3OC(C)(C)C(O)Cc3c2O)cc1
Show InChI InChI=1S/C21H24O5/c1-21(2)19(23)12-16-18(26-21)11-9-15(20(16)24)17(22)10-6-13-4-7-14(25-3)8-5-13/h4-5,7-9,11,19,23-24H,6,10,12H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.26E+4n/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 min...


Bioorg Med Chem 22: 1115-20 (2014)


Article DOI: 10.1016/j.bmc.2013.12.047
BindingDB Entry DOI: 10.7270/Q2222XQ8
More data for this
Ligand-Target Pair
Polyphenol oxidase 2


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.73E+4n/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 min...


Bioorg Med Chem 22: 1115-20 (2014)


Article DOI: 10.1016/j.bmc.2013.12.047
BindingDB Entry DOI: 10.7270/Q2222XQ8
More data for this
Ligand-Target Pair
Polyphenol oxidase 2


(Agaricus bisporus (Common mushroom))
BDBM50495310
PNG
(Lupinifolin)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c2-[#8]-[#6@@H](-[#6]-[#6](=O)-c2c(-[#8])c2-[#6]=[#6]C([#6])([#6])[#8]-c12)-c1ccc(-[#8])cc1 |r,c:17|
Show InChI InChI=1S/C25H26O5/c1-14(2)5-10-18-23-17(11-12-25(3,4)30-23)22(28)21-19(27)13-20(29-24(18)21)15-6-8-16(26)9-7-15/h5-9,11-12,20,26,28H,10,13H2,1-4H3/t20-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.41E+4n/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15 min...


Bioorg Med Chem 22: 1115-20 (2014)


Article DOI: 10.1016/j.bmc.2013.12.047
BindingDB Entry DOI: 10.7270/Q2222XQ8
More data for this
Ligand-Target Pair