Found 13 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 50013222 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50132433
![PNG](/data/jpeg/tenK5013/BindingDB_50132433.png) (3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)Show SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3cn(C)c4ccc(OC)cc34)c2c1 Show InChI InChI=1S/C20H19N3O4S/c1-21-28(25,26)14-5-6-18-16(10-14)17(20(24)22-18)8-12-11-23(2)19-7-4-13(27-3)9-15(12)19/h4-11,21H,1-3H3,(H,22,24)/b17-8- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50132450
![PNG](/data/jpeg/tenK5013/BindingDB_50132450.png) (3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)Show SMILES COc1ccc2n(C)cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1 Show InChI InChI=1S/C19H17N3O4S/c1-22-10-11(14-8-12(26-2)3-6-18(14)22)7-16-15-9-13(27(20,24)25)4-5-17(15)21-19(16)23/h3-10H,1-2H3,(H,21,23)(H2,20,24,25)/b16-7- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50132436
![PNG](/data/jpeg/tenK5013/BindingDB_50132436.png) (3-((1-methyl-1H-indol-3-yl)methylene)-2-oxoindolin...)Show SMILES Cn1cc(\C=C2/C(=O)Nc3ccc(cc23)S(N)(=O)=O)c2ccccc12 Show InChI InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50563812
![PNG](/data/jpeg/tenK5056/BindingDB_50563812.png) (CHEMBL4788922)Show SMILES NS(=O)(=O)c1ccc2NC(=O)\C(=C/c3c[nH]c4ccc(O)cc34)c2c1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50132445
![PNG](/data/jpeg/tenK5013/BindingDB_50132445.png) (3-[1-(5-Methoxy-1H-indol-3-yl)-meth-(Z)-ylidene]-2...)Show SMILES COc1ccc2[nH]cc(\C=C3/C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1 Show InChI InChI=1S/C18H15N3O4S/c1-25-11-2-4-16-13(7-11)10(9-20-16)6-15-14-8-12(26(19,23)24)3-5-17(14)21-18(15)22/h2-9,20H,1H3,(H,21,22)(H2,19,23,24)/b15-6- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50563810
![PNG](/data/jpeg/tenK5056/BindingDB_50563810.png) (CHEMBL4798255)Show SMILES CN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C/c3cn(C)c4ccc(O)cc34)c2c1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50132455
![PNG](/data/jpeg/tenK5013/BindingDB_50132455.png) (3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)Show SMILES COc1ccc2n(C)cc(\C=C3/C(=O)Nc4ccc(cc34)S(=O)(=O)N(C)C)c2c1 Show InChI InChI=1S/C21H21N3O4S/c1-23(2)29(26,27)15-6-7-19-17(11-15)18(21(25)22-19)9-13-12-24(3)20-8-5-14(28-4)10-16(13)20/h5-12H,1-4H3,(H,22,25)/b18-9- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50132453
![PNG](/data/jpeg/tenK5013/BindingDB_50132453.png) (3-[1-(1H-Indol-3-yl)-meth-(Z)-ylidene]-2-oxo-2,3-d...)Show SMILES NS(=O)(=O)c1ccc2NC(=O)\C(=C/c3c[nH]c4ccccc34)c2c1 Show InChI InChI=1S/C17H13N3O3S/c18-24(22,23)11-5-6-16-13(8-11)14(17(21)20-16)7-10-9-19-15-4-2-1-3-12(10)15/h1-9,19H,(H,20,21)(H2,18,22,23)/b14-7- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50243715
![PNG](/data/jpeg/tenK5024/BindingDB_50243715.png) (3-((1-methyl-1H-indol-3-yl)methylene)indolin-2-one...)Show InChI InChI=1S/C18H14N2O/c1-20-11-12(13-6-3-5-9-17(13)20)10-15-14-7-2-4-8-16(14)19-18(15)21/h2-11H,1H3,(H,19,21)/b15-10- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50239208
![PNG](/data/jpeg/tenK5023/BindingDB_50239208.png) (CHEMBL4074055)Show InChI InChI=1S/C18H14N2O2/c1-22-12-6-7-16-14(9-12)11(10-19-16)8-15-13-4-2-3-5-17(13)20-18(15)21/h2-10,19H,1H3,(H,20,21)/b15-8- | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50563811
![PNG](/data/jpeg/tenK5056/BindingDB_50563811.png) (CHEMBL476643) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50563813
![PNG](/data/jpeg/tenK5056/BindingDB_50563813.png) (CHEMBL382707 | HTS-05069) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50375670
![PNG](/data/jpeg/tenK5037/BindingDB_50375670.png) (CHEMBL261425)Show InChI InChI=1S/C17H11ClN2O/c18-16-12(10-5-1-3-7-14(10)19-16)9-13-11-6-2-4-8-15(11)20-17(13)21/h1-9,19H,(H,20,21)/b13-9+ | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TrkA (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2016.06.003 BindingDB Entry DOI: 10.7270/Q2474FKS |
More data for this Ligand-Target Pair | |