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Compile Data Set for Download or QSAR

Found 433 hits Enz. Inhib. hit(s) with all data for assayid = 4 entry = 2763   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379569
PNG
(US9926281, Compound 65)
Show SMILES Cc1ccc(Cl)cc1N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1ccccn1
Show InChI InChI=1S/C22H24ClN5O3/c1-15-5-6-16(23)14-17(15)27-10-12-28(13-11-27)19(29)7-8-22(18-4-2-3-9-24-18)20(30)25-21(31)26-22/h2-6,9,14H,7-8,10-13H2,1H3,(H2,25,26,30,31)
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n/an/a 56n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379771
PNG
(US9926281, Compound 231 | US9926281, Compound 434)
Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C22H23Cl2N5O3/c1-14(13-22(18-4-2-3-5-25-18)20(31)26-21(32)27-22)19(30)29-8-6-28(7-9-29)17-11-15(23)10-16(24)12-17/h2-5,10-12,14H,6-9,13H2,1H3,(H2,26,27,31,32)
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n/an/a 106n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379771
PNG
(US9926281, Compound 231 | US9926281, Compound 434)
Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C22H23Cl2N5O3/c1-14(13-22(18-4-2-3-5-25-18)20(31)26-21(32)27-22)19(30)29-8-6-28(7-9-29)17-11-15(23)10-16(24)12-17/h2-5,10-12,14H,6-9,13H2,1H3,(H2,26,27,31,32)
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n/an/a 106n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379590
PNG
(US9926281, Compound 87)
Show SMILES Cc1ccc(C)c(c1)N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1ccccn1
Show InChI InChI=1S/C23H27N5O3/c1-16-6-7-17(2)18(15-16)27-11-13-28(14-12-27)20(29)8-9-23(19-5-3-4-10-24-19)21(30)25-22(31)26-23/h3-7,10,15H,8-9,11-14H2,1-2H3,(H2,25,26,30,31)
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n/an/a 120n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379673
PNG
(US9926281, Compound 197)
Show SMILES CSCCC1(CC(C)C(=O)N2CCN(CC2)c2cc(Cl)cc(Cl)c2)NC(=O)NC1=O
Show InChI InChI=1S/C20H26Cl2N4O3S/c1-13(12-20(3-8-30-2)18(28)23-19(29)24-20)17(27)26-6-4-25(5-7-26)16-10-14(21)9-15(22)11-16/h9-11,13H,3-8,12H2,1-2H3,(H2,23,24,28,29)
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n/an/a 134n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379559
PNG
(US9926281, Compound 46)
Show SMILES Cc1ccc(Cl)cc1N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1cccnc1
Show InChI InChI=1S/C22H24ClN5O3/c1-15-4-5-17(23)13-18(15)27-9-11-28(12-10-27)19(29)6-7-22(16-3-2-8-24-14-16)20(30)25-21(31)26-22/h2-5,8,13-14H,6-7,9-12H2,1H3,(H2,25,26,30,31)
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n/an/a 137n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379924
PNG
(US9926281, Compound 410)
Show SMILES CC(CC1(C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H22Cl2N4O3/c1-11(10-18(2)16(26)21-17(27)22-18)15(25)24-5-3-23(4-6-24)14-8-12(19)7-13(20)9-14/h7-9,11H,3-6,10H2,1-2H3,(H2,21,22,26,27)
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n/an/a 170n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379744
PNG
(US9926281, Compound 133)
Show SMILES COc1ccc(Cl)cc1C1(CCC(=O)N2CCN(CC2)c2cc(Cl)ccc2C)NC(=O)NC1=O
Show InChI InChI=1S/C24H26Cl2N4O4/c1-15-3-4-17(26)14-19(15)29-9-11-30(12-10-29)21(31)7-8-24(22(32)27-23(33)28-24)18-13-16(25)5-6-20(18)34-2/h3-6,13-14H,7-12H2,1-2H3,(H2,27,28,32,33)
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n/an/a 195n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379770
PNG
(US9926281, Compound 230)
Show SMILES COCC1(CC(C)C(=O)N2CCN(CC2)c2cc(F)ccc2C)NC(=O)NC1=O
Show InChI InChI=1S/C20H27FN4O4/c1-13-4-5-15(21)10-16(13)24-6-8-25(9-7-24)17(26)14(2)11-20(12-29-3)18(27)22-19(28)23-20/h4-5,10,14H,6-9,11-12H2,1-3H3,(H2,22,23,27,28)
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n/an/a 207n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379591
PNG
(US9926281, Compound 88)
Show SMILES Cc1ccc(C)c(c1)N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1cccnc1
Show InChI InChI=1S/C23H27N5O3/c1-16-5-6-17(2)19(14-16)27-10-12-28(13-11-27)20(29)7-8-23(18-4-3-9-24-15-18)21(30)25-22(31)26-23/h3-6,9,14-15H,7-8,10-13H2,1-2H3,(H2,25,26,30,31)
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n/an/a 211n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379780
PNG
(US9926281, Compound 236 | US9926281, Compound 435)
Show SMILES CCC(CC1(C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C19H24Cl2N4O3/c1-3-12(11-19(2)17(27)22-18(28)23-19)16(26)25-6-4-24(5-7-25)15-9-13(20)8-14(21)10-15/h8-10,12H,3-7,11H2,1-2H3,(H2,22,23,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379780
PNG
(US9926281, Compound 236 | US9926281, Compound 435)
Show SMILES CCC(CC1(C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C19H24Cl2N4O3/c1-3-12(11-19(2)17(27)22-18(28)23-19)16(26)25-6-4-24(5-7-25)15-9-13(20)8-14(21)10-15/h8-10,12H,3-7,11H2,1-2H3,(H2,22,23,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379760
PNG
(US9926281, Compound 220 | US9926281, Compound 425)
Show SMILES CC1(CC(CO)C(=O)N2CCN(CC2)c2cc(Cl)cc(Cl)c2)NC(=O)NC1=O
Show InChI InChI=1S/C18H22Cl2N4O4/c1-18(16(27)21-17(28)22-18)9-11(10-25)15(26)24-4-2-23(3-5-24)14-7-12(19)6-13(20)8-14/h6-8,11,25H,2-5,9-10H2,1H3,(H2,21,22,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379760
PNG
(US9926281, Compound 220 | US9926281, Compound 425)
Show SMILES CC1(CC(CO)C(=O)N2CCN(CC2)c2cc(Cl)cc(Cl)c2)NC(=O)NC1=O
Show InChI InChI=1S/C18H22Cl2N4O4/c1-18(16(27)21-17(28)22-18)9-11(10-25)15(26)24-4-2-23(3-5-24)14-7-12(19)6-13(20)8-14/h6-8,11,25H,2-5,9-10H2,1H3,(H2,21,22,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379652
PNG
(US9926281, Compound 175)
Show SMILES CC(CC1(C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(F)ccc1C
Show InChI InChI=1S/C19H25FN4O3/c1-12-4-5-14(20)10-15(12)23-6-8-24(9-7-23)16(25)13(2)11-19(3)17(26)21-18(27)22-19/h4-5,10,13H,6-9,11H2,1-3H3,(H2,21,22,26,27)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379692
PNG
(US9926281, Compound 218)
Show SMILES CC(CC1(CCS(C)(=O)=O)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C20H26Cl2N4O5S/c1-13(12-20(3-8-32(2,30)31)18(28)23-19(29)24-20)17(27)26-6-4-25(5-7-26)16-10-14(21)9-15(22)11-16/h9-11,13H,3-8,12H2,1-2H3,(H2,23,24,28,29)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379582
PNG
(US9926281, Compound 79)
Show SMILES COc1ccc(cc1)C1(CCC(=O)N2CCN(CC2)c2cc(Cl)ccc2C)NC(=O)NC1=O
Show InChI InChI=1S/C24H27ClN4O4/c1-16-3-6-18(25)15-20(16)28-11-13-29(14-12-28)21(30)9-10-24(22(31)26-23(32)27-24)17-4-7-19(33-2)8-5-17/h3-8,15H,9-14H2,1-2H3,(H2,26,27,31,32)
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n/an/a 277n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379552
PNG
(US9926281, Compound 24)
Show SMILES Cc1ccc(Cl)cc1N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1ccccc1
Show InChI InChI=1S/C23H25ClN4O3/c1-16-7-8-18(24)15-19(16)27-11-13-28(14-12-27)20(29)9-10-23(17-5-3-2-4-6-17)21(30)25-22(31)26-23/h2-8,15H,9-14H2,1H3,(H2,25,26,30,31)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379649
PNG
(US9926281, Compound 172 | US9926281, Compound 409)
Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C20H24Cl2N4O3/c1-12(11-20(13-2-3-13)18(28)23-19(29)24-20)17(27)26-6-4-25(5-7-26)16-9-14(21)8-15(22)10-16/h8-10,12-13H,2-7,11H2,1H3,(H2,23,24,28,29)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379649
PNG
(US9926281, Compound 172 | US9926281, Compound 409)
Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C20H24Cl2N4O3/c1-12(11-20(13-2-3-13)18(28)23-19(29)24-20)17(27)26-6-4-25(5-7-26)16-9-14(21)8-15(22)10-16/h8-10,12-13H,2-7,11H2,1H3,(H2,23,24,28,29)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379651
PNG
(US9926281, Compound 174)
Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN(CC1)c1cc(F)ccc1C
Show InChI InChI=1S/C21H27FN4O3/c1-13-3-6-16(22)11-17(13)25-7-9-26(10-8-25)18(27)14(2)12-21(15-4-5-15)19(28)23-20(29)24-21/h3,6,11,14-15H,4-5,7-10,12H2,1-2H3,(H2,23,24,28,29)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379762
PNG
(US9926281, Compound 222 | US9926281, Compound 427)
Show SMILES COCC1(CC(C)C(=O)N2CCN(CC2)c2cc(Cl)cc(Cl)c2)NC(=O)NC1=O
Show InChI InChI=1S/C19H24Cl2N4O4/c1-12(10-19(11-29-2)17(27)22-18(28)23-19)16(26)25-5-3-24(4-6-25)15-8-13(20)7-14(21)9-15/h7-9,12H,3-6,10-11H2,1-2H3,(H2,22,23,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379762
PNG
(US9926281, Compound 222 | US9926281, Compound 427)
Show SMILES COCC1(CC(C)C(=O)N2CCN(CC2)c2cc(Cl)cc(Cl)c2)NC(=O)NC1=O
Show InChI InChI=1S/C19H24Cl2N4O4/c1-12(10-19(11-29-2)17(27)22-18(28)23-19)16(26)25-5-3-24(4-6-25)15-8-13(20)7-14(21)9-15/h7-9,12H,3-6,10-11H2,1-2H3,(H2,22,23,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379743
PNG
(US9926281, Compound 132)
Show SMILES COc1ccc(Cl)cc1C1(CCC(=O)N2CCN(CC2)c2cccc(Cl)c2)NC(=O)NC1=O
Show InChI InChI=1S/C23H24Cl2N4O4/c1-33-19-6-5-16(25)14-18(19)23(21(31)26-22(32)27-23)8-7-20(30)29-11-9-28(10-12-29)17-4-2-3-15(24)13-17/h2-6,13-14H,7-12H2,1H3,(H2,26,27,31,32)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379975
PNG
(US9926281, Compound 436)
Show SMILES COCC(CC1(C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C19H24Cl2N4O4/c1-19(17(27)22-18(28)23-19)10-12(11-29-2)16(26)25-5-3-24(4-6-25)15-8-13(20)7-14(21)9-15/h7-9,12H,3-6,10-11H2,1-2H3,(H2,22,23,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379934
PNG
(US9926281, Compound 415)
Show SMILES CC(CC1(COCc2ccccc2)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C25H28Cl2N4O4/c1-17(22(32)31-9-7-30(8-10-31)21-12-19(26)11-20(27)13-21)14-25(23(33)28-24(34)29-25)16-35-15-18-5-3-2-4-6-18/h2-6,11-13,17H,7-10,14-16H2,1H3,(H2,28,29,33,34)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379804
PNG
(US9926281, Compound 250 | US9926281, Compound 440)
Show SMILES Cc1cc(Cl)c(Cl)cc1N1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O
Show InChI InChI=1S/C18H22Cl2N4O3/c1-11-9-12(19)13(20)10-14(11)23-5-7-24(8-6-23)15(25)3-4-18(2)16(26)21-17(27)22-18/h9-10H,3-8H2,1-2H3,(H2,21,22,26,27)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379804
PNG
(US9926281, Compound 250 | US9926281, Compound 440)
Show SMILES Cc1cc(Cl)c(Cl)cc1N1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O
Show InChI InChI=1S/C18H22Cl2N4O3/c1-11-9-12(19)13(20)10-14(11)23-5-7-24(8-6-23)15(25)3-4-18(2)16(26)21-17(27)22-18/h9-10H,3-8H2,1-2H3,(H2,21,22,26,27)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379554
PNG
(US9926281, Compound 33)
Show SMILES CC(C)C1(CCC(=O)N2CCN(CC2)c2cc(Cl)ccc2C)NC(=O)NC1=O
Show InChI InChI=1S/C20H27ClN4O3/c1-13(2)20(18(27)22-19(28)23-20)7-6-17(26)25-10-8-24(9-11-25)16-12-15(21)5-4-14(16)3/h4-5,12-13H,6-11H2,1-3H3,(H2,22,23,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379676
PNG
(US9926281, Compound 200 | US9926281, Compound 219)
Show SMILES CC(CC1NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C17H20Cl2N4O3/c1-10(6-14-15(24)21-17(26)20-14)16(25)23-4-2-22(3-5-23)13-8-11(18)7-12(19)9-13/h7-10,14H,2-6H2,1H3,(H2,20,21,24,26)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379544
PNG
(US9926281, Compound 16)
Show SMILES Cc1ccc(Cl)cc1N1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O
Show InChI InChI=1S/C18H23ClN4O3/c1-12-3-4-13(19)11-14(12)22-7-9-23(10-8-22)15(24)5-6-18(2)16(25)20-17(26)21-18/h3-4,11H,5-10H2,1-2H3,(H2,20,21,25,26)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379607
PNG
(US9926281, Compound 104)
Show SMILES Cc1ccc(F)cc1N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1ccccn1
Show InChI InChI=1S/C22H24FN5O3/c1-15-5-6-16(23)14-17(15)27-10-12-28(13-11-27)19(29)7-8-22(18-4-2-3-9-24-18)20(30)25-21(31)26-22/h2-6,9,14H,7-8,10-13H2,1H3,(H2,25,26,30,31)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379938
PNG
(US9926281, Compound 417)
Show SMILES CC(CC1(CO)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H22Cl2N4O4/c1-11(9-18(10-25)16(27)21-17(28)22-18)15(26)24-4-2-23(3-5-24)14-7-12(19)6-13(20)8-14/h6-8,11,25H,2-5,9-10H2,1H3,(H2,21,22,27,28)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379751
PNG
(US9926281, Compound 407)
Show SMILES Clc1cc(Cl)cc(c1)N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1ccccn1
Show InChI InChI=1S/C21H21Cl2N5O3/c22-14-11-15(23)13-16(12-14)27-7-9-28(10-8-27)18(29)4-5-21(17-3-1-2-6-24-17)19(30)25-20(31)26-21/h1-3,6,11-13H,4-5,7-10H2,(H2,25,26,30,31)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379578
PNG
(US9926281, Compound 75)
Show SMILES Cc1ccc(Cl)cc1N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H24Cl2N4O3/c1-15-2-5-18(25)14-19(15)28-10-12-29(13-11-28)20(30)8-9-23(21(31)26-22(32)27-23)16-3-6-17(24)7-4-16/h2-7,14H,8-13H2,1H3,(H2,26,27,31,32)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379714
PNG
(US9926281, Compound 39)
Show SMILES Cc1ccc(C)c(c1)N1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O
Show InChI InChI=1S/C19H26N4O3/c1-13-4-5-14(2)15(12-13)22-8-10-23(11-9-22)16(24)6-7-19(3)17(25)20-18(26)21-19/h4-5,12H,6-11H2,1-3H3,(H2,20,21,25,26)
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University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379557
PNG
(US9926281, Compound 36)
Show SMILES Cc1ccc(Cl)cc1N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)C1CC1
Show InChI InChI=1S/C20H25ClN4O3/c1-13-2-5-15(21)12-16(13)24-8-10-25(11-9-24)17(26)6-7-20(14-3-4-14)18(27)22-19(28)23-20/h2,5,12,14H,3-4,6-11H2,1H3,(H2,22,23,27,28)
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Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379656
PNG
(US9926281, Compound 179)
Show SMILES CC(CC1(C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cccc(Cl)c1C
Show InChI InChI=1S/C19H25ClN4O3/c1-12(11-19(3)17(26)21-18(27)22-19)16(25)24-9-7-23(8-10-24)15-6-4-5-14(20)13(15)2/h4-6,12H,7-11H2,1-3H3,(H2,21,22,26,27)
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n/an/a 785n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379981
PNG
(US9926281, Compound 439)
Show SMILES COC(CC1(C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H22Cl2N4O4/c1-18(16(26)21-17(27)22-18)10-14(28-2)15(25)24-5-3-23(4-6-24)13-8-11(19)7-12(20)9-13/h7-9,14H,3-6,10H2,1-2H3,(H2,21,22,26,27)
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n/an/a 787n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379987
PNG
(US9926281, Compound 442)
Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cc(Cl)cc(Cl)c1 |r|
Show InChI InChI=1S/C23H25Cl2N5O3/c1-14(12-23(19-5-3-4-6-26-19)21(32)27-22(33)28-23)20(31)29-7-8-30(15(2)13-29)18-10-16(24)9-17(25)11-18/h3-6,9-11,14-15H,7-8,12-13H2,1-2H3,(H2,27,28,32,33)/t14?,15-,23?/m0/s1
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n/an/a 789n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379674
PNG
(US9926281, Compound 198)
Show SMILES CC(CC1(CC2CCN(CC2)C(=O)OC(C)(C)C)NC(=O)NC1=O)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H39Cl2N5O5/c1-18(23(36)34-11-9-33(10-12-34)22-14-20(29)13-21(30)15-22)16-28(24(37)31-25(38)32-28)17-19-5-7-35(8-6-19)26(39)40-27(2,3)4/h13-15,18-19H,5-12,16-17H2,1-4H3,(H2,31,32,37,38)
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n/an/a 817n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379839
PNG
(US9926281, Compound 269 | US9926281, Compound 446)
Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C23H26ClN5O3/c1-15(13-23(19-8-3-4-9-25-19)21(31)26-22(32)27-23)20(30)28-10-11-29(16(2)14-28)18-7-5-6-17(24)12-18/h3-9,12,15-16H,10-11,13-14H2,1-2H3,(H2,26,27,31,32)/t15?,16-,23?/m0/s1
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n/an/a 840n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379839
PNG
(US9926281, Compound 269 | US9926281, Compound 446)
Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C23H26ClN5O3/c1-15(13-23(19-8-3-4-9-25-19)21(31)26-22(32)27-23)20(30)28-10-11-29(16(2)14-28)18-7-5-6-17(24)12-18/h3-9,12,15-16H,10-11,13-14H2,1-2H3,(H2,26,27,31,32)/t15?,16-,23?/m0/s1
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n/an/a 840n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379621
PNG
(US9926281, Compound 124)
Show SMILES CS(=O)(=O)c1ccc(cc1)C1(CCC(=O)N2CCN(CC2)c2cccc(Cl)c2)NC(=O)NC1=O
Show InChI InChI=1S/C23H25ClN4O5S/c1-34(32,33)19-7-5-16(6-8-19)23(21(30)25-22(31)26-23)10-9-20(29)28-13-11-27(12-14-28)18-4-2-3-17(24)15-18/h2-8,15H,9-14H2,1H3,(H2,25,26,30,31)
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n/an/a 880n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379889
PNG
(US9926281, Compound 341)
Show SMILES C[C@H]1CN(CCN1c1ccc2cnn(C)c2c1)C(=O)CCC1(NC(=O)NC1=O)C1CC1 |r|
Show InChI InChI=1S/C22H28N6O3/c1-14-13-27(9-10-28(14)17-6-3-15-12-23-26(2)18(15)11-17)19(29)7-8-22(16-4-5-16)20(30)24-21(31)25-22/h3,6,11-12,14,16H,4-5,7-10,13H2,1-2H3,(H2,24,25,30,31)/t14-,22?/m0/s1
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n/an/a 885n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379614
PNG
(US9926281, Compound 111)
Show SMILES Clc1cc(Cl)cc(c1)N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1cccnc1
Show InChI InChI=1S/C21H21Cl2N5O3/c22-15-10-16(23)12-17(11-15)27-6-8-28(9-7-27)18(29)3-4-21(14-2-1-5-24-13-14)19(30)25-20(31)26-21/h1-2,5,10-13H,3-4,6-9H2,(H2,25,26,30,31)
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n/an/a 963n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379592
PNG
(US9926281, Compound 89)
Show SMILES Cc1ccc(C)c(c1)N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)C1CC1
Show InChI InChI=1S/C21H28N4O3/c1-14-3-4-15(2)17(13-14)24-9-11-25(12-10-24)18(26)7-8-21(16-5-6-16)19(27)22-20(28)23-21/h3-4,13,16H,5-12H2,1-2H3,(H2,22,23,27,28)
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n/an/a 984n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379812
PNG
(US9926281, Compound 254)
Show SMILES CC1(CC(CC#N)C(=O)N2CCN(CC2)c2cc(Cl)cc(Cl)c2)NC(=O)NC1=O
Show InChI InChI=1S/C19H21Cl2N5O3/c1-19(17(28)23-18(29)24-19)11-12(2-3-22)16(27)26-6-4-25(5-7-26)15-9-13(20)8-14(21)10-15/h8-10,12H,2,4-7,11H2,1H3,(H2,23,24,28,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379595
PNG
(US9926281, Compound 92)
Show SMILES Cc1ccc(F)cc1N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)c1cccnc1
Show InChI InChI=1S/C22H24FN5O3/c1-15-4-5-17(23)13-18(15)27-9-11-28(12-10-27)19(29)6-7-22(16-3-2-8-24-14-16)20(30)25-21(31)26-22/h2-5,8,13-14H,6-7,9-12H2,1H3,(H2,25,26,30,31)
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n/an/a 1.05E+3n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17


(Homo sapiens (Human))		BDBM379675
PNG
(US9926281, Compound 199)
Show SMILES CC(CC1(NC(=O)NC1=O)C1CCOCC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C22H28Cl2N4O4/c1-14(13-22(15-2-8-32-9-3-15)20(30)25-21(31)26-22)19(29)28-6-4-27(5-7-28)18-11-16(23)10-17(24)12-18/h10-12,14-15H,2-9,13H2,1H3,(H2,25,26,30,31)
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n/an/a 1.05E+3n/an/an/an/an/an/a



University of Illinois at Chicago



Assay Description
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...

J Med Chem 51: 3437-48 (2008)


BindingDB Entry DOI: 10.7270/Q27S7R3T
More data for this
Ligand-Target Pair
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