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Target
Sequence
Name
&
Ki
IC50
Kd
EC50
Rate constants
ΔG°
ΔH°
-TΔS°
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Ki
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Found
10
hits Enz. Inhib. hit(s) with all data for assayid = 7 entry = 50015293
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585046
(CHEMBL5086263)
Show SMILES
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
5
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585053
(CHEMBL5089965)
Show SMILES
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(-c4cn(CCCC1=O)nc4C(F)(F)F)c3n2
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
18
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585045
(CHEMBL5093741)
Show SMILES
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
19
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585049
(CHEMBL5075321)
Show SMILES
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(C)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
55
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585047
(CHEMBL5075335)
Show SMILES
CN1Cc2nn(C)cc2-c2cnc3[nH]cc(-c4cnn(CCCC1=O)c4)c3c2
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
70
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585050
(CHEMBL5081601)
Show SMILES
COc1c-2c(CN(C(C)C)C(=O)CCCn3cc(-c4c[nH]c5ncc-2cc45)c(n3)C(F)(F)F)nn1C
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
146
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585048
(CHEMBL5079894)
Show SMILES
CN1Cc2nn(C)cc2-c2cnc3[nH]cc(-c4cnn(CCCCC1=O)c4)c3c2
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
150
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585051
(CHEMBL5086482)
Show SMILES
COc1c-2c(CN(C(C)C)C(=O)CCCn3cc(c(n3)C(F)(F)F)-c3c(C)[nH]c4ncc-2cc34)nn1C
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
533
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585052
(CHEMBL5089643)
Show SMILES
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]nc(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
929
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50585054
(CHEMBL5088208)
Show SMILES
CN1Cc2nn(C)c(C#N)c2-c2cc3c(c[nH]c3nn2)-c2cn(CCCC1=O)nc2C(F)(F)F
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
3.05E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
Citation and Details
Article DOI:
10.1021/acsmedchemlett.1c00630
BindingDB Entry DOI:
10.7270/Q2183BDB
More data for this
Ligand-Target Pair
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