Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Smoothened homolog (Homo sapiens (Human)) | BDBM50249488 (4-benzyl-N-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323401 (4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323402 (4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323411 (1-((1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)me...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50184796 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323410 (1-(4-methoxyphenyl)-4-((5-methyl-1-phenyl-1H-pyraz...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323409 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-(3...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 328 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323405 (1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 823 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323404 (1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323406 (1-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)met...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323403 (1-((3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methyl)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323407 (1-(4-methoxyphenyl)-4-((3-methyl-1-phenyl-1H-pyraz...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Smoothened homolog (Homo sapiens (Human)) | BDBM50323408 (1-(4-fluorophenyl)-4-((3-methyl-1-phenyl-1H-pyrazo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F | |||||||||||
More data for this Ligand-Target Pair |