Found 6 hits Enz. Inhib. hit(s) with all data for assayid = 9 entry = 50007428 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50509370
(CHEMBL4446434)Show SMILES COc1cc(Br)cc2[nH]cc(-c3cnc(o3)-c3ccc[nH]3)c12 Show InChI InChI=1S/C16H12BrN3O2/c1-21-13-6-9(17)5-12-15(13)10(7-19-12)14-8-20-16(22-14)11-3-2-4-18-11/h2-8,18-19H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway
Curated by ChEMBL
| Assay Description
Inhibition of TAK1 (unknown origin) by [33P]-ATP filter binding kinase assay |
J Med Chem 62: 10167-10181 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01006
BindingDB Entry DOI: 10.7270/Q26M3B4R |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50509365
(CHEMBL4564337)Show SMILES COc1cc2c(c[nH]c2cc1Br)-c1cnc(o1)-c1ccc[nH]1 Show InChI InChI=1S/C16H12BrN3O2/c1-21-14-5-9-10(7-19-13(9)6-11(14)17)15-8-20-16(22-15)12-3-2-4-18-12/h2-8,18-19H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway
Curated by ChEMBL
| Assay Description
Inhibition of TAK1 (unknown origin) by [33P]-ATP filter binding kinase assay |
J Med Chem 62: 10167-10181 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01006
BindingDB Entry DOI: 10.7270/Q26M3B4R |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50509366
(CHEMBL4555884)Show SMILES COc1cc(Br)cc2[nH]cc(-c3oc(nc3I)-c3ccc[nH]3)c12 Show InChI InChI=1S/C16H11BrIN3O2/c1-22-12-6-8(17)5-11-13(12)9(7-20-11)14-15(18)21-16(23-14)10-3-2-4-19-10/h2-7,19-20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway
Curated by ChEMBL
| Assay Description
Inhibition of TAK1 (unknown origin) by [33P]-ATP filter binding kinase assay |
J Med Chem 62: 10167-10181 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01006
BindingDB Entry DOI: 10.7270/Q26M3B4R |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50509368
(CHEMBL4475097)Show SMILES COc1cc(Br)cc2[nH]cc(-c3cnc(o3)-c3ccc(Br)[nH]3)c12 Show InChI InChI=1S/C16H11Br2N3O2/c1-22-12-5-8(17)4-11-15(12)9(6-19-11)13-7-20-16(23-13)10-2-3-14(18)21-10/h2-7,19,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway
Curated by ChEMBL
| Assay Description
Inhibition of TAK1 (unknown origin) by [33P]-ATP filter binding kinase assay |
J Med Chem 62: 10167-10181 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01006
BindingDB Entry DOI: 10.7270/Q26M3B4R |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50509369
(CHEMBL4548361)Show SMILES COc1cc(Br)cc2[nH]c(I)c(-c3cnc(o3)-c3ccc[nH]3)c12 Show InChI InChI=1S/C16H11BrIN3O2/c1-22-11-6-8(17)5-10-13(11)14(15(18)21-10)12-7-20-16(23-12)9-3-2-4-19-9/h2-7,19,21H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway
Curated by ChEMBL
| Assay Description
Inhibition of TAK1 (unknown origin) by [33P]-ATP filter binding kinase assay |
J Med Chem 62: 10167-10181 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01006
BindingDB Entry DOI: 10.7270/Q26M3B4R |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50509367
(CHEMBL4476426)Show SMILES COc1cc(Br)cc2[nH]cc(-c3cnc(o3)-c3cc(Br)c[nH]3)c12 Show InChI InChI=1S/C16H11Br2N3O2/c1-22-13-4-8(17)2-11-15(13)10(6-20-11)14-7-21-16(23-14)12-3-9(18)5-19-12/h2-7,19-20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway
Curated by ChEMBL
| Assay Description
Inhibition of TAK1 (unknown origin) by [33P]-ATP filter binding kinase assay |
J Med Chem 62: 10167-10181 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01006
BindingDB Entry DOI: 10.7270/Q26M3B4R |
More data for this
Ligand-Target Pair | |
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