Compile Data Set for Download or QSAR

Found 3346 hits of ic50 for UniProtKB: Q9BQA1   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578799 (4-(aminomethyl)-6-(4-benzyl-4H-1,2,4-triazol-3- yl...) Show SMILES NCc1n[nH]c(=O)c2ccc(cc12)-c1nncn1Cc1ccccc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578810 (4-(aminomethyl)-6-(1-methyl-3-(trifluoromethyl)-1H...) Show SMILES Cn1nc(cc1-c1ccc2c(c1)c(CN)n[nH]c2=O)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578828 (4-(aminomethyl)-6-(1-methyl-1H-pyrrolo[2,3-b]pyrid...) Show SMILES Cn1cc(-c2ccc3c(c2)c(CN)n[nH]c3=O)c2cccnc12 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578954 (US11479551, Example 13-1 | US11479551, Example 6-2...) Show SMILES Brc1ccc2c(CN3C(=O)c4ccccc4C3=O)n[nH]c(=O)c2c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578799 (4-(aminomethyl)-6-(4-benzyl-4H-1,2,4-triazol-3- yl...) Show SMILES NCc1n[nH]c(=O)c2ccc(cc12)-c1nncn1Cc1ccccc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578810 (4-(aminomethyl)-6-(1-methyl-3-(trifluoromethyl)-1H...) Show SMILES Cn1nc(cc1-c1ccc2c(c1)c(CN)n[nH]c2=O)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578828 (4-(aminomethyl)-6-(1-methyl-1H-pyrrolo[2,3-b]pyrid...) Show SMILES Cn1cc(-c2ccc3c(c2)c(CN)n[nH]c3=O)c2cccnc12 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578954 (US11479551, Example 13-1 | US11479551, Example 6-2...) Show SMILES Brc1ccc2c(CN3C(=O)c4ccccc4C3=O)n[nH]c(=O)c2c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50462572 (CHEMBL4249337) Show SMILES Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br |r| Show InChI InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523629 (CHEMBL4564327) Show SMILES Cc1cnc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)c(Cl)cn12 |r| Show InChI InChI=1S/C21H23ClN6O2/c1-11-8-24-17-7-12(15(22)9-28(11)17)2-3-13-6-16(19(30)18(13)29)27-5-4-14-20(23)25-10-26-21(14)27/h4-5,7-10,13,16,18-19,29-30H,2-3,6H2,1H3,(H2,23,25,26)/t13-,16+,18+,19-/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM533464 ((E)-7-((2R,3R,4S,5S)-5-((1R)-1-(3,4- dichlorocyclo...) Show SMILES C[C@](O)([C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2c1[nH]cn\c2=N\O)C1CC=C(Cl)C(Cl)=C1 |r,c:30,t:26| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5...				Citation and Details BindingDB Entry DOI: 10.7270/Q25142D7
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM533479 ((Z)-7-((1R,2S,3R,4S)-4-(2-(2-amino- 3-chloroquinol...) Show SMILES CO\N=c1/nc[nH]c2n(ccc12)[C@@H]1C[C@H](CCc2ccc3cc(Cl)c(N)nc3c2)[C@@H](O)[C@H]1O |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5...				Citation and Details BindingDB Entry DOI: 10.7270/Q25142D7
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523642 (CHEMBL4539612) Show SMILES Cc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccn2c1C |r| Show InChI InChI=1S/C22H26N6O2/c1-12-13(2)27-7-5-14(9-18(27)26-12)3-4-15-10-17(20(30)19(15)29)28-8-6-16-21(23)24-11-25-22(16)28/h5-9,11,15,17,19-20,29-30H,3-4,10H2,1-2H3,(H2,23,24,25)/t15-,17+,19+,20-/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515298 (US11098059, Example 2 | US11098059, Example 6) Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515310 (US11098059, Example 14) Show SMILES CC[C@H]1CN(C[C@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523646 (CHEMBL4541714) Show SMILES Nc1ccc2ccc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)cc2n1 |r| Show InChI InChI=1S/C22H24N6O2/c23-18-6-5-13-3-1-12(9-16(13)27-18)2-4-14-10-17(20(30)19(14)29)28-8-7-15-21(24)25-11-26-22(15)28/h1,3,5-9,11,14,17,19-20,29-30H,2,4,10H2,(H2,23,27)(H2,24,25,26)/t14-,17+,19+,20-/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515307 (6'-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-2'-{(2R)...) Show SMILES O[C@H](CN1CC2(CCC2)c2cc(ccc2C1=O)-c1ncnn1C1CC1)[C@@H]1Cc2ccccc2CN1 |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM533440 ((2R,3S,4R,5R)-2-((R)-(3,4- dichlorophenyl)(hydroxy...) Show SMILES CN\N=c1/nc[nH]c2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)c(Cl)c2)[C@@H](O)[C@H]1O |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5...				Citation and Details BindingDB Entry DOI: 10.7270/Q25142D7
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515299 (US11098059, Example 3 | US11098059, Example 7) Show SMILES CC[C@@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(Br)cc12 |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523655 (CHEMBL4577464) Show SMILES Cc1cnc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)c(F)cn12 |r| Show InChI InChI=1S/C21H23FN6O2/c1-11-8-24-17-7-12(15(22)9-28(11)17)2-3-13-6-16(19(30)18(13)29)27-5-4-14-20(23)25-10-26-21(14)27/h4-5,7-10,13,16,18-19,29-30H,2-3,6H2,1H3,(H2,23,25,26)/t13-,16+,18+,19-/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM533482 ((Z)-7-((1R,2S,3R,4S)-4-(2-(2- ((cyclopropylmethyl)...) Show SMILES O\N=c1/nc[nH]c2n(ccc12)[C@@H]1C[C@H](CCc2ccc3ccc(NCC4CC4)nc3c2)[C@@H](O)[C@H]1O |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5...				Citation and Details BindingDB Entry DOI: 10.7270/Q25142D7
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515323 (6-(hexahydro-3,6- epiminofuro[3,2-b]furan- 7-carbo...) Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2COC3C1COC23 |r,TLB:26:28:30.31:36,30:29:32:34.35,31:32:28.29:34.35,THB:26:28:32:34.35,34:33:30.31:36,35:36:30.31:33.28| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515309 (US11098059, Example 13) Show SMILES CC[C@H]1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM533414 (7-((2R,3R,4S,5R)-5-((R)-(3,4- dichlorophenyl)(hydr...) Show SMILES O\N=c1/nc[nH]c2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)c(Cl)c2)[C@@H](O)[C@H]1O |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized, and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5...				Citation and Details BindingDB Entry DOI: 10.7270/Q25142D7
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515306 (6-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-4-ethyl-2...) Show SMILES CCC1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)-c1ncnn1C1CC1 |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523643 (CHEMBL4454890) Show SMILES Nc1cccc(CCCC[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(N)ncnc23)n1 |r| Show InChI InChI=1S/C20H26N6O2/c21-16-7-3-6-13(25-16)5-2-1-4-12-10-15(18(28)17(12)27)26-9-8-14-19(22)23-11-24-20(14)26/h3,6-9,11-12,15,17-18,27-28H,1-2,4-5,10H2,(H2,21,25)(H2,22,23,24)/t12-,15+,17+,18-/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515321 (2-((R)-2-hydroxy-2-((S)- 1,2,3,4- tetrahydroisoqui...) Show SMILES CO[C@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1 |r,THB:10:9:8.2.3:6.5| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515305 (6-(1-cyclopropyl-1H-1,2,4-triazol-5-yl)-2-{(2R)-2-...) Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)-c1ncnn1C1CC1 |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578895 (4-(aminomethyl)-6-(5-(2- methoxyphenoxy)pyridin-3-...) Show SMILES COc1ccccc1Oc1cncc(c1)-c1ccc2c(c1)c(CN)n[nH]c2=O Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578831 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES COc1cccc(-c2c(cnn2C)-c2ccc3c(c2)c(CN)n[nH]c3=O)c1C#N |(-6.5,-1.85,;-5.41,-2.93,;-3.92,-2.54,;-2.83,-3.62,;-1.34,-3.23,;-.95,-1.74,;-2.03,-.65,;-1.64,.84,;-.17,1.31,;-.17,2.85,;-1.64,3.33,;-2.54,2.08,;-4.08,2.08,;1.16,.54,;1.16,-1,;2.5,-1.77,;3.83,-1,;3.83,.54,;2.5,1.31,;5.16,1.31,;5.16,2.85,;6.5,3.62,;6.5,.54,;6.5,-1,;5.16,-1.77,;5.16,-3.31,;-3.52,-1.05,;-4.61,.04,;-5.7,1.13,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578829 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES Cc1ccc(-c2c(cnn2C)-c2ccc3c(c2)c(CN)n[nH]c3=O)c(c1)C#N |(-3.63,-4.37,;-3.23,-2.88,;-1.74,-2.48,;-1.34,-.99,;-2.43,.09,;-2.03,1.58,;-.57,2.06,;-.57,3.6,;-2.03,4.07,;-2.94,2.83,;-4.48,2.83,;.76,1.29,;.76,-.25,;2.1,-1.02,;3.43,-.25,;3.43,1.29,;2.1,2.06,;4.76,2.06,;4.76,3.6,;6.1,4.37,;6.1,1.29,;6.1,-.25,;4.76,-1.02,;4.76,-2.56,;-3.92,-.3,;-4.32,-1.79,;-5.01,.78,;-6.1,1.87,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578825 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES COc1ccc(C#N)c(c1)-c1c(cnn1C)-c1ccc2c(c1)c(CN)n[nH]c2=O |(.83,-3.57,;-.65,-3.97,;-1.74,-2.88,;-3.23,-3.28,;-4.32,-2.19,;-3.92,-.7,;-5.01,.39,;-6.1,1.48,;-2.43,-.3,;-1.34,-1.39,;-2.03,1.18,;-.57,1.66,;-.57,3.2,;-2.03,3.68,;-2.94,2.43,;-4.48,2.43,;.76,.89,;.76,-.65,;2.1,-1.42,;3.43,-.65,;3.43,.89,;2.1,1.66,;4.76,1.66,;4.76,3.2,;6.1,3.97,;6.1,.89,;6.1,-.65,;4.76,-1.42,;4.76,-2.96,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578823 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES Cn1ncc(c1-c1cc(Cl)ccc1C#N)-c1ccc2c(c1)c(CN)n[nH]c2=O |(-4.48,2.43,;-2.94,2.43,;-2.03,3.68,;-.57,3.2,;-.57,1.66,;-2.03,1.18,;-2.43,-.3,;-1.34,-1.39,;-1.74,-2.88,;-.65,-3.97,;-3.23,-3.28,;-4.32,-2.19,;-3.92,-.7,;-5.01,.39,;-6.1,1.48,;.76,.89,;.76,-.65,;2.1,-1.42,;3.43,-.65,;3.43,.89,;2.1,1.66,;4.76,1.66,;4.76,3.2,;6.1,3.97,;6.1,.89,;6.1,-.65,;4.76,-1.42,;4.76,-2.96,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578821 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES Cn1ncc(c1-c1ccc(Cl)cc1C#N)-c1ccc2c(c1)c(CN)n[nH]c2=O |(-4.48,2.83,;-2.94,2.83,;-2.03,4.07,;-.57,3.6,;-.57,2.06,;-2.03,1.58,;-2.43,.09,;-1.34,-.99,;-1.74,-2.48,;-3.23,-2.88,;-3.63,-4.37,;-4.32,-1.79,;-3.92,-.3,;-5.01,.78,;-6.1,1.87,;.76,1.29,;.76,-.25,;2.1,-1.02,;3.43,-.25,;3.43,1.29,;2.1,2.06,;4.76,2.06,;4.76,3.6,;6.1,4.37,;6.1,1.29,;6.1,-.25,;4.76,-1.02,;4.76,-2.56,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578819 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES Cn1ncc(c1-c1ccccc1C#N)-c1ccc2c(c1)c(CN)n[nH]c2=O |(-4.48,2.08,;-2.94,2.08,;-2.03,3.33,;-.57,2.85,;-.57,1.31,;-2.03,.84,;-2.43,-.65,;-1.34,-1.74,;-1.74,-3.23,;-3.23,-3.62,;-4.32,-2.54,;-3.92,-1.05,;-5.01,.04,;-6.1,1.13,;.76,.54,;.76,-1,;2.1,-1.77,;3.43,-1,;3.43,.54,;2.1,1.31,;4.76,1.31,;4.76,2.85,;3.43,3.62,;6.1,.54,;6.1,-1,;4.76,-1.77,;4.76,-3.31,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q23F4SWQ
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM435525 ((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...) Show SMILES C[C@@]1(O)[C@@H](COc2ccc3cc(Br)c(N)nc3c2)O[C@H]([C@@H]1O)n1ccc2c(N)ncnc12 |r| Show InChI InChI=1S/C21H21BrN6O4/c1-21(30)15(8-31-11-3-2-10-6-13(22)18(24)27-14(10)7-11)32-20(16(21)29)28-5-4-12-17(23)25-9-26-19(12)28/h2-7,9,15-16,20,29-30H,8H2,1H3,(H2,24,27)(H2,23,25,26)/t15-,16+,20-,21-/m1/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...				Citation and Details BindingDB Entry DOI: 10.7270/Q2N58QJ4
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515319 (US11098059, Example 23) Show SMILES CO[C@@H]1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc2C(=O)N(C[C@@H](O)[C@@H]3Cc4ccccc4CN3)CC(C)(C)c2c1 |r,THB:10:9:8.2.3:6.5| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578831 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES COc1cccc(-c2c(cnn2C)-c2ccc3c(c2)c(CN)n[nH]c3=O)c1C#N |(-6.5,-1.85,;-5.41,-2.93,;-3.92,-2.54,;-2.83,-3.62,;-1.34,-3.23,;-.95,-1.74,;-2.03,-.65,;-1.64,.84,;-.17,1.31,;-.17,2.85,;-1.64,3.33,;-2.54,2.08,;-4.08,2.08,;1.16,.54,;1.16,-1,;2.5,-1.77,;3.83,-1,;3.83,.54,;2.5,1.31,;5.16,1.31,;5.16,2.85,;6.5,3.62,;6.5,.54,;6.5,-1,;5.16,-1.77,;5.16,-3.31,;-3.52,-1.05,;-4.61,.04,;-5.7,1.13,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578895 (4-(aminomethyl)-6-(5-(2- methoxyphenoxy)pyridin-3-...) Show SMILES COc1ccccc1Oc1cncc(c1)-c1ccc2c(c1)c(CN)n[nH]c2=O Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM435525 ((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...) Show SMILES C[C@@]1(O)[C@@H](COc2ccc3cc(Br)c(N)nc3c2)O[C@H]([C@@H]1O)n1ccc2c(N)ncnc12 |r| Show InChI InChI=1S/C21H21BrN6O4/c1-21(30)15(8-31-11-3-2-10-6-13(22)18(24)27-14(10)7-11)32-20(16(21)29)28-5-4-12-17(23)25-9-26-19(12)28/h2-7,9,15-16,20,29-30H,8H2,1H3,(H2,24,27)(H2,23,25,26)/t15-,16+,20-,21-/m1/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Incorporated US Patent					Assay Description Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...				US Patent US10570140 (2020) BindingDB Entry DOI: 10.7270/Q2WM1GTT
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578829 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES Cc1ccc(-c2c(cnn2C)-c2ccc3c(c2)c(CN)n[nH]c3=O)c(c1)C#N |(-3.63,-4.37,;-3.23,-2.88,;-1.74,-2.48,;-1.34,-.99,;-2.43,.09,;-2.03,1.58,;-.57,2.06,;-.57,3.6,;-2.03,4.07,;-2.94,2.83,;-4.48,2.83,;.76,1.29,;.76,-.25,;2.1,-1.02,;3.43,-.25,;3.43,1.29,;2.1,2.06,;4.76,2.06,;4.76,3.6,;6.1,4.37,;6.1,1.29,;6.1,-.25,;4.76,-1.02,;4.76,-2.56,;-3.92,-.3,;-4.32,-1.79,;-5.01,.78,;-6.1,1.87,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578819 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES Cn1ncc(c1-c1ccccc1C#N)-c1ccc2c(c1)c(CN)n[nH]c2=O |(-4.48,2.08,;-2.94,2.08,;-2.03,3.33,;-.57,2.85,;-.57,1.31,;-2.03,.84,;-2.43,-.65,;-1.34,-1.74,;-1.74,-3.23,;-3.23,-3.62,;-4.32,-2.54,;-3.92,-1.05,;-5.01,.04,;-6.1,1.13,;.76,.54,;.76,-1,;2.1,-1.77,;3.43,-1,;3.43,.54,;2.1,1.31,;4.76,1.31,;4.76,2.85,;3.43,3.62,;6.1,.54,;6.1,-1,;4.76,-1.77,;4.76,-3.31,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578821 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES Cn1ncc(c1-c1ccc(Cl)cc1C#N)-c1ccc2c(c1)c(CN)n[nH]c2=O |(-4.48,2.83,;-2.94,2.83,;-2.03,4.07,;-.57,3.6,;-.57,2.06,;-2.03,1.58,;-2.43,.09,;-1.34,-.99,;-1.74,-2.48,;-3.23,-2.88,;-3.63,-4.37,;-4.32,-1.79,;-3.92,-.3,;-5.01,.78,;-6.1,1.87,;.76,1.29,;.76,-.25,;2.1,-1.02,;3.43,-.25,;3.43,1.29,;2.1,2.06,;4.76,2.06,;4.76,3.6,;6.1,4.37,;6.1,1.29,;6.1,-.25,;4.76,-1.02,;4.76,-2.56,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578823 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES Cn1ncc(c1-c1cc(Cl)ccc1C#N)-c1ccc2c(c1)c(CN)n[nH]c2=O |(-4.48,2.43,;-2.94,2.43,;-2.03,3.68,;-.57,3.2,;-.57,1.66,;-2.03,1.18,;-2.43,-.3,;-1.34,-1.39,;-1.74,-2.88,;-.65,-3.97,;-3.23,-3.28,;-4.32,-2.19,;-3.92,-.7,;-5.01,.39,;-6.1,1.48,;.76,.89,;.76,-.65,;2.1,-1.42,;3.43,-.65,;3.43,.89,;2.1,1.66,;4.76,1.66,;4.76,3.2,;6.1,3.97,;6.1,.89,;6.1,-.65,;4.76,-1.42,;4.76,-2.96,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578825 (2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...) Show SMILES COc1ccc(C#N)c(c1)-c1c(cnn1C)-c1ccc2c(c1)c(CN)n[nH]c2=O |(.83,-3.57,;-.65,-3.97,;-1.74,-2.88,;-3.23,-3.28,;-4.32,-2.19,;-3.92,-.7,;-5.01,.39,;-6.1,1.48,;-2.43,-.3,;-1.34,-1.39,;-2.03,1.18,;-.57,1.66,;-.57,3.2,;-2.03,3.68,;-2.94,2.43,;-4.48,2.43,;.76,.89,;.76,-.65,;2.1,-1.42,;3.43,-.65,;3.43,.89,;2.1,1.66,;4.76,1.66,;4.76,3.2,;6.1,3.97,;6.1,.89,;6.1,-.65,;4.76,-1.42,;4.76,-2.96,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515317 (US11098059, Example 21) Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1[C@H]2CC[C@@H]1C[C@H](O)C2 |r,THB:26:28:33.34.36:31.30| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM515315 (US11098059, Example 19) Show SMILES CC1(C)CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2 |r| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...				Citation and Details BindingDB Entry DOI: 10.7270/Q26D5X5X
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578885 (4-(aminomethyl)-6-(5-(2,4- dimethylphenoxy)pyridin...) Show SMILES Cc1ccc(Oc2cncc(c2)-c2ccc3c(c2)c(CN)n[nH]c3=O)c(C)c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM578922 (4-(aminomethyl)-6-(3-(methoxymethyl)-1H- pyrrolo[2...) Show SMILES COCc1c[nH]c2ncc(cc12)-c1ccc2c(c1)c(CN)n[nH]c2=O Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V128N9
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM50523663 (CHEMBL4536042) Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc2c1[nH]cn\c2=N/N)[C@H](O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C17H18ClN5O4/c18-9-3-1-8(2-4-9)11(24)14-12(25)13(26)17(27-14)23-6-5-10-15(22-19)20-7-21-16(10)23/h1-7,11-14,17,24-26H,19H2,(H,20,21,22)/t11-,12+,13-,14-,17-/m1/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Prelude Therapeutics Curated by ChEMBL					Assay Description Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...				Bioorg Med Chem Lett 29: 1264-1269 (2019) Article DOI: 10.1016/j.bmcl.2019.03.042 BindingDB Entry DOI: 10.7270/Q2ZC869N
					More data for this Ligand-Target Pair

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