Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E] (Dengue virus 2 (strain TSV01)) | BDBM33250 (phthalazine-based compound, 1) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | 7.20E+3 | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E] (Dengue virus 2 (strain TSV01)) | BDBM33252 (phthalazine-based compound, 3) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+3 | 7.70E+3 | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E] (Dengue virus 2 (strain TSV01)) | BDBM33257 (phthalazine-based compound, 8) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.02E+4 | 1.63E+4 | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E] (Dengue virus 2 (strain TSV01)) | BDBM33254 (phthalazine-based compound, 5) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.80E+3 | 1.86E+4 | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E] (Dengue virus 2 (strain TSV01)) | BDBM33253 (phthalazine-based compound, 4) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.74E+4 | 2.29E+4 | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E] (Dengue virus 2 (strain TSV01)) | BDBM33255 (phthalazine-based compound, 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.50E+4 | 5.40E+4 | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E] (Dengue virus 2 (strain TSV01)) | BDBM33258 (phthalazine-based compound, 9) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | 1.00E+5 | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair |