Compile Data Set for Download or QSAR

Found 11 hits of ki for UniProtKB: P49356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50143597 ((S)-2-(2-[2-(4-Fluoro-phenyl)-ethyl]-5-{[(1S,4S)-4...) Show SMILES CSCC[C@H](NC(=O)c1cc(NC[C@@H]2C[C@@H](CN2)SC(=O)c2cccnc2)ccc1CCc1ccc(F)cc1)C(=O)OC(C)C Show InChI InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9-6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38-28)45-34(42)25-5-4-15-36-19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H,6,9,14,16-17,20-21H2,1-3H3,(H,39,40)/t28-,29-,31-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition binding constant against Farnesyltransferase				J Med Chem 47: 1869-78 (2004) Article DOI: 10.1021/jm0305467 BindingDB Entry DOI: 10.7270/Q2RX9CVX
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088001 ((+/-)-11-[2-(2-methoxyphenyl)acryloyl]-1-phenyl-(1...) Show SMILES COc1ccccc1C(=C)C(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccccc2)c2ccccc12)C(O)=O |THB:28:27:15.14:19.18,31:32:15.14:19.18| Show InChI InChI=1S/C31H29NO4/c1-20(22-12-7-9-15-26(22)36-2)28(33)32-18-27-30(21-10-4-3-5-11-21)17-16-25(31(27,19-32)29(34)35)23-13-6-8-14-24(23)30/h3-15,25,27H,1,16-19H2,2H3,(H,34,35)/t25-,27+,30-,31+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088009 ((+/-)-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,...) Show SMILES COc1ccccc1CC(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccccc2)c2ccccc12)C(O)=O |THB:30:31:14.13:18.17,27:26:14.13:18.17| Show InChI InChI=1S/C30H29NO4/c1-35-25-14-8-5-9-20(25)17-27(32)31-18-26-29(21-10-3-2-4-11-21)16-15-24(30(26,19-31)28(33)34)22-12-6-7-13-23(22)29/h2-14,24,26H,15-19H2,1H3,(H,33,34)/t24-,26+,29-,30+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088004 (8-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-...) Show SMILES COc1ccccc1CC(=O)N1C[C@@H]2[C@@](C1)(C(O)=O)[C@]1(O)CC[C@@]2(c2ccccc2)c2ccccc12 Show InChI InChI=1S/C30H29NO5/c1-36-24-14-8-5-9-20(24)17-26(32)31-18-25-28(21-10-3-2-4-11-21)15-16-30(35,29(25,19-31)27(33)34)23-13-7-6-12-22(23)28/h2-14,25,35H,15-19H2,1H3,(H,33,34)/t25-,28+,29-,30-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088008 (11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8R,9S,...) Show SMILES CONC(=O)[C@]12CN(C[C@H]1[C@]1(CC[C@@H]2c2ccccc12)c1ccccc1)C(=O)Cc1ccccc1OC |THB:15:14:5.9:11.12,18:19:5.9:11.12| Show InChI InChI=1S/C31H32N2O4/c1-36-26-15-9-6-10-21(26)18-28(34)33-19-27-30(22-11-4-3-5-12-22)17-16-25(23-13-7-8-14-24(23)30)31(27,20-33)29(35)32-37-2/h3-15,25,27H,16-20H2,1-2H3,(H,32,35)/t25-,27+,30-,31+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088014 (1-(2,3-dihydrobenzo[b]furan-5-yl)-11-[2-(2-methoxy...) Show SMILES COc1ccccc1C(=C)C(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccc3OCCc3c2)c2ccccc12)C(O)=O |THB:31:30:15.14:19.18,34:35:15.14:19.18| Show InChI InChI=1S/C33H31NO5/c1-20(23-7-4-6-10-28(23)38-2)30(35)34-18-29-32(22-11-12-27-21(17-22)14-16-39-27)15-13-26(33(29,19-34)31(36)37)24-8-3-5-9-25(24)32/h3-12,17,26,29H,1,13-16,18-19H2,2H3,(H,36,37)/t26-,29+,32-,33+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088013 (2-[11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8R,...) Show SMILES COc1ccccc1CC(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccccc2)c2ccccc12)C(=O)NCC(O)=O |THB:27:26:14.13:18.17,30:31:14.13:18.17| Show InChI InChI=1S/C32H32N2O5/c1-39-26-14-8-5-9-21(26)17-28(35)34-19-27-31(22-10-3-2-4-11-22)16-15-25(23-12-6-7-13-24(23)31)32(27,20-34)30(38)33-18-29(36)37/h2-14,25,27H,15-20H2,1H3,(H,33,38)(H,36,37)/t25-,27+,31-,32+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	738	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088002 (1-(4-carboxymethoxyphenyl)-11-[2-(2-methoxyphenyl)...) Show SMILES COc1ccccc1C(=C)C(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccc(OCC(O)=O)cc2)c2ccccc12)C(O)=O |THB:36:37:15.14:19.18,33:32:15.14:19.18| Show InChI InChI=1S/C33H31NO7/c1-20(23-7-4-6-10-27(23)40-2)30(37)34-17-28-32(21-11-13-22(14-12-21)41-18-29(35)36)16-15-26(33(28,19-34)31(38)39)24-8-3-5-9-25(24)32/h3-14,26,28H,1,15-19H2,2H3,(H,35,36)(H,38,39)/t26-,28+,32-,33+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.55E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088003 (11-[2-(2-benzyloxyphenyl)acetyl]-1-phenyl-(1R,8R,9...) Show SMILES OC(=O)[C@]12CN(C[C@H]1[C@]1(CC[C@@H]2c2ccccc12)c1ccccc1)C(=O)Cc1ccccc1OCc1ccccc1 |THB:13:12:3.7:9.10,16:17:3.7:9.10| Show InChI InChI=1S/C36H33NO4/c38-33(21-26-13-7-10-18-31(26)41-23-25-11-3-1-4-12-25)37-22-32-35(27-14-5-2-6-15-27)20-19-30(36(32,24-37)34(39)40)28-16-8-9-17-29(28)35/h1-18,30,32H,19-24H2,(H,39,40)/t30-,32+,35-,36+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088005 (2-(2-methoxyphenyl)-1-[1-phenyl-(1R,8S,9R,13R)-11-...) Show SMILES COc1ccccc1CC(=O)N1C[C@H]2[C@@H](C1)[C@]1(CC[C@@H]2c2ccccc12)c1ccccc1 Show InChI InChI=1S/C29H29NO2/c1-32-27-14-8-5-9-20(27)17-28(31)30-18-24-22-15-16-29(26(24)19-30,21-10-3-2-4-11-21)25-13-7-6-12-23(22)25/h2-14,22,24,26H,15-19H2,1H3/t22-,24-,26-,29-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50088006 (6-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-...) Show SMILES COc1ccccc1CC(=O)N1C[C@@H]2[C@](C1)([C@@H]1CC[C@@]2(c2ccccc2)c2cccc(O)c12)C(O)=O |THB:30:32:14.13:18.17,27:26:14.13:18.17| Show InChI InChI=1S/C30H29NO5/c1-36-24-13-6-5-8-19(24)16-26(33)31-17-25-29(20-9-3-2-4-10-20)15-14-22(30(25,18-31)28(34)35)27-21(29)11-7-12-23(27)32/h2-13,22,25,32H,14-18H2,1H3,(H,34,35)/t22-,25+,29-,30+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer S.A. Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase by Ras/SPA assay				J Med Chem 43: 1807-16 (2000) BindingDB Entry DOI: 10.7270/Q23N22MR
					More data for this Ligand-Target Pair