Compile Data Set for Download or QSAR

Found 46 hits of ec50 for UniProtKB: P18507   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164567 (2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C18H13BrCl2N2O2/c1-2-25-18(24)15-10-23(16-8-7-13(20)9-14(16)21)17(22-15)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50052792 (CHEBI:7035 | Muscimol) Show SMILES NCc1cc(O)no1 Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	407	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50052792 (CHEBI:7035 | Muscimol) Show SMILES NCc1cc(O)no1 Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	410	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164569 (1-(2,4-Dichloro-phenyl)-2-(4-iodo-phenyl)-1H-imida...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C18H13Cl2IN2O2/c1-2-25-18(24)15-10-23(16-8-5-12(19)9-14(16)20)17(22-15)11-3-6-13(21)7-4-11/h3-10H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164557 (2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C18H13Cl3N2O2/c1-2-25-18(24)15-10-23(16-8-7-13(20)9-14(16)21)17(22-15)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM24183 (4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...) Show SMILES NCCCC(O)=O Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	650	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM24183 (4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...) Show SMILES NCCCC(O)=O Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	661	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50052799 (CHEMBL3322882) Show SMILES NC1=NCC(CC1)C(O)=O |t:1| Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	820	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50052799 (CHEMBL3322882) Show SMILES NC1=NCC(CC1)C(O)=O |t:1| Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	832	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164579 (1-(2,4-Dichloro-phenyl)-2-p-tolyl-1H-imidazole-4-c...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(C)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H16Cl2N2O2/c1-3-25-19(24)16-11-23(17-9-8-14(20)10-15(17)21)18(22-16)13-6-4-12(2)5-7-13/h4-11H,3H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50459890 (Bromophene | CHEBI:70620) Show SMILES Oc1c(Br)cc(Br)cc1-c1cc(Br)cc(Br)c1O Show InChI InChI=1S/C12H6Br4O2/c13-5-1-7(11(17)9(15)3-5)8-2-6(14)4-10(16)12(8)18/h1-4,17-18H	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Agonist activity at recombinant human GABAA receptor alpha2beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...				Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164562 (CHEMBL192127 | [2-(4-Chloro-phenyl)-1-(2,4-dichlor...) Show SMILES CN1CCN(CC1)C(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C21H19Cl3N4O/c1-26-8-10-27(11-9-26)21(29)18-13-28(19-7-6-16(23)12-17(19)24)20(25-18)14-2-4-15(22)5-3-14/h2-7,12-13H,8-11H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164558 (1,2-Bis-(4-chloro-phenyl)-1H-imidazole-4-carboxyli...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C18H14Cl2N2O2/c1-2-24-18(23)16-11-22(15-9-7-14(20)8-10-15)17(21-16)12-3-5-13(19)6-4-12/h3-11H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164576 (2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...) Show SMILES CCCOC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H15BrCl2N2O2/c1-2-9-26-19(25)16-11-24(17-8-7-14(21)10-15(17)22)18(23-16)12-3-5-13(20)6-4-12/h3-8,10-11H,2,9H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164566 (1-(2,4-Dichloro-phenyl)-2-phenyl-1H-imidazole-4-ca...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccccc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C18H14Cl2N2O2/c1-2-24-18(23)15-11-22(16-9-8-13(19)10-14(16)20)17(21-15)12-6-4-3-5-7-12/h3-11H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164573 (1-(2,4-Dichloro-phenyl)-2-(4-methoxy-phenyl)-1H-im...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(OC)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H16Cl2N2O3/c1-3-26-19(24)16-11-23(17-9-6-13(20)10-15(17)21)18(22-16)12-4-7-14(25-2)8-5-12/h4-11H,3H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164570 ((3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-...) Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C Show InChI InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164578 (2-(4-Chloro-phenyl)-1-(3,4-dichloro-phenyl)-1H-imi...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C18H13Cl3N2O2/c1-2-25-18(24)16-10-23(13-7-8-14(20)15(21)9-13)17(22-16)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164577 (1-(2,4-Dichloro-phenyl)-2-(4-nitro-phenyl)-1H-imid...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(cc1)[N+]([O-])=O)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C18H13Cl2N3O4/c1-2-27-18(24)15-10-22(16-8-5-12(19)9-14(16)20)17(21-15)11-3-6-13(7-4-11)23(25)26/h3-10H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164575 (1-(3-Chloro-phenyl)-2-phenyl-1H-imidazole-4-carbox...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccccc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN2O2/c1-2-23-18(22)16-12-21(15-10-6-9-14(19)11-15)17(20-16)13-7-4-3-5-8-13/h3-12H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164561 (1,2-Bis-(4-fluoro-phenyl)-1H-imidazole-4-carboxyli...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(F)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C18H14F2N2O2/c1-2-24-18(23)16-11-22(15-9-7-14(20)8-10-15)17(21-16)12-3-5-13(19)6-4-12/h3-11H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164574 (2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...) Show SMILES COC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C17H11BrCl2N2O2/c1-24-17(23)14-9-22(15-7-6-12(19)8-13(15)20)16(21-14)10-2-4-11(18)5-3-10/h2-9H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 |r| Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164559 (1-Phenyl-2-p-tolyl-1H-imidazole-4-carboxylic acid ...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(C)cc1)-c1ccccc1 Show InChI InChI=1S/C19H18N2O2/c1-3-23-19(22)17-13-21(16-7-5-4-6-8-16)18(20-17)15-11-9-14(2)10-12-15/h4-13H,3H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164560 (2-(4-Chloro-phenyl)-1-phenyl-1H-imidazole-4-carbox...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccccc1 Show InChI InChI=1S/C18H15ClN2O2/c1-2-23-18(22)16-12-21(15-6-4-3-5-7-15)17(20-16)13-8-10-14(19)11-9-13/h3-12H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164564 (2-(4-Amino-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(N)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C18H15Cl2N3O2/c1-2-25-18(24)15-10-23(16-8-5-12(19)9-14(16)20)17(22-15)11-3-6-13(21)7-4-11/h3-10H,2,21H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164563 (2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...) Show SMILES CCN(CC)C(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C20H18Cl3N3O/c1-3-25(4-2)20(27)17-12-26(18-10-9-15(22)11-16(18)23)19(24-17)13-5-7-14(21)8-6-13/h5-12H,3-4H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50032955 (1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | 1,...) Show SMILES OC(=O)C1=CCNCC1 |t:3| Show InChI InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.47E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50032955 (1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | 1,...) Show SMILES OC(=O)C1=CCNCC1 |t:3| Show InChI InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164565 (1,2-Diphenyl-1H-imidazole-4-carboxylic acid ethyl ...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C18H16N2O2/c1-2-22-18(21)16-13-20(15-11-7-4-8-12-15)17(19-16)14-9-5-3-6-10-14/h3-13H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50459889 (CHEMBL4224740) Show SMILES COc1ccc(cc1)C(=O)\C=C\c1cc(OC)ccc1O Show InChI InChI=1S/C17H16O4/c1-20-14-6-3-12(4-7-14)16(18)9-5-13-11-15(21-2)8-10-17(13)19/h3-11,19H,1-2H3/b9-5+	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of recombinant wild type GABAA receptor alpha2beta2gamma2S (unknown origin) expressed in HEK293 cells assessed as pote...				Bioorg Med Chem Lett 27: 3207-3218 (2017) Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164568 (2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...) Show SMILES OC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-20-13(16(22)23)8-21(15)14-6-5-11(18)7-12(14)19/h1-8H,(H,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164572 (2-(4-Methoxy-phenyl)-1-phenyl-1H-imidazole-4-carbo...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(OC)cc1)-c1ccccc1 Show InChI InChI=1S/C19H18N2O3/c1-3-24-19(22)17-13-21(15-7-5-4-6-8-15)18(20-17)14-9-11-16(23-2)12-10-14/h4-13H,3H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50052801 (CHEMBL3322886) Show SMILES NC1=NCC(CN1)C(O)=O |t:1| Show InChI InChI=1S/C5H9N3O2/c6-5-7-1-3(2-8-5)4(9)10/h3H,1-2H2,(H,9,10)(H3,6,7,8)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.33E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50052801 (CHEMBL3322886) Show SMILES NC1=NCC(CN1)C(O)=O |t:1| Show InChI InChI=1S/C5H9N3O2/c6-5-7-1-3(2-8-5)4(9)10/h3H,1-2H2,(H,9,10)(H3,6,7,8)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50058046 (CHEMBL526 | propofol) Show SMILES CC(C)c1cccc(C(C)C)c1O Show InChI InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50497208 (CHEMBL3289196) Show SMILES CCCCN(CCCC)C(=O)\C=C\C=C\c1ccc2OCOc2c1 Show InChI InChI=1S/C20H27NO3/c1-3-5-13-21(14-6-4-2)20(22)10-8-7-9-17-11-12-18-19(15-17)24-16-23-18/h7-12,15H,3-6,13-14,16H2,1-2H3/b9-7+,10-8+	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.48E+4	n/a	n/a	n/a	n/a
University of Vienna Curated by ChEMBL					Assay Description Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as modulation of GABA-induced chloride ...				J Med Chem 57: 5602-19 (2014) Article DOI: 10.1021/jm5002277 BindingDB Entry DOI: 10.7270/Q25X2CXW
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164571 (2-(4-Acetylamino-phenyl)-1-(2,4-dichloro-phenyl)-1...) Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(NC(C)=O)cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C20H17Cl2N3O3/c1-3-28-20(27)17-11-25(18-9-6-14(21)10-16(18)22)19(24-17)13-4-7-15(8-5-13)23-12(2)26/h4-11H,3H2,1-2H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50000106 (4-CARBOXYPIPERIDINE | CHEMBL279998 | Piperidine-4-...) Show SMILES OC(=O)C1CCNCC1 Show InChI InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50000106 (4-CARBOXYPIPERIDINE | CHEMBL279998 | Piperidine-4-...) Show SMILES OC(=O)C1CCNCC1 Show InChI InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50497206 (CHEMBL3289195) Show SMILES CCCN(CCC)C(=O)\C=C\C=C\c1ccc2OCOc2c1 Show InChI InChI=1S/C18H23NO3/c1-3-11-19(12-4-2)18(20)8-6-5-7-15-9-10-16-17(13-15)22-14-21-16/h5-10,13H,3-4,11-12,14H2,1-2H3/b7-5+,8-6+	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.64E+4	n/a	n/a	n/a	n/a
University of Vienna Curated by ChEMBL					Assay Description Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as modulation of GABA-induced chloride ...				J Med Chem 57: 5602-19 (2014) Article DOI: 10.1021/jm5002277 BindingDB Entry DOI: 10.7270/Q25X2CXW
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50055935 (5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidi...) Show SMILES CCCC(C)C1(CC)C(=O)NC(=O)NC1=O Show InChI InChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...				J Med Chem 48: 2638-45 (2005) Article DOI: 10.1021/jm049120y BindingDB Entry DOI: 10.7270/Q2VH5PMS
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM246487 (Batatasin III (4)) Show SMILES COc1cc(O)cc(CCc2cccc(O)c2)c1 Show InChI InChI=1S/C15H16O3/c1-18-15-9-12(8-14(17)10-15)6-5-11-3-2-4-13(16)7-11/h2-4,7-10,16-17H,5-6H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	8.08E+4	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 to 10 GABA-induc...				Bioorg Med Chem 22: 1276-84 (2014) Article DOI: 10.1016/j.bmc.2014.01.008 BindingDB Entry DOI: 10.7270/Q2B56NQ0
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50060088 (2-(6-Chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N...) Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccccc1 Show InChI InChI=1S/C21H24ClN3O/c1-3-12-24(13-4-2)20(26)14-18-21(16-8-6-5-7-9-16)23-19-11-10-17(22)15-25(18)19/h5-11,15H,3-4,12-14H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30E+9	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits				J Med Chem 40: 3109-18 (1997) Article DOI: 10.1021/jm970112+ BindingDB Entry DOI: 10.7270/Q2PN9699
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM26266 (Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...) Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.80E+9	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits				J Med Chem 40: 3109-18 (1997) Article DOI: 10.1021/jm970112+ BindingDB Entry DOI: 10.7270/Q2PN9699
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50060124 (2-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyri...) Show SMILES Clc1ccc(cc1)-c1nc2ccc(Cl)cn2c1CC(=O)N1CCCC1 Show InChI InChI=1S/C19H17Cl2N3O/c20-14-5-3-13(4-6-14)19-16(11-18(25)23-9-1-2-10-23)24-12-15(21)7-8-17(24)22-19/h3-8,12H,1-2,9-11H2	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.60E+9	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits				J Med Chem 40: 3109-18 (1997) Article DOI: 10.1021/jm970112+ BindingDB Entry DOI: 10.7270/Q2PN9699
					More data for this Ligand-Target Pair