Found 7 hits of ic50 for UniProtKB: P53610 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus (rat)) | BDBM50075437
(2,4,5-Trifluoro-6-nitro-3-((2E,6E)-3,7,11-trimethy...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-c1c(F)c(-[#8])c(c(F)c1F)-[#7+](-[#8-])=O Show InChI InChI=1S/C21H26F3NO4/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-29-21-17(23)16(22)19(25(27)28)20(26)18(21)24/h7,9,11,26H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 9: 623-6 (1999)
BindingDB Entry DOI: 10.7270/Q28P5ZN0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus (rat)) | BDBM50075439
(3-Benzyloxy-2,4,5-trifluoro-6-nitro-phenol | CHEMB...)Show InChI InChI=1S/C13H8F3NO4/c14-8-9(15)13(10(16)12(18)11(8)17(19)20)21-6-7-4-2-1-3-5-7/h1-5,18H,6H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 9: 623-6 (1999)
BindingDB Entry DOI: 10.7270/Q28P5ZN0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus (rat)) | BDBM50075440
(2,4,5-Trifluoro-3-(4-isopropenyl-cyclohex-1-enylme...)Show SMILES CC(=C)C1CCC(COc2c(F)c(O)c(c(F)c2F)[N+]([O-])=O)=CC1 |c:22| Show InChI InChI=1S/C16H16F3NO4/c1-8(2)10-5-3-9(4-6-10)7-24-16-12(18)11(17)14(20(22)23)15(21)13(16)19/h3,10,21H,1,4-7H2,2H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 9: 623-6 (1999)
BindingDB Entry DOI: 10.7270/Q28P5ZN0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus (rat)) | BDBM50075443
(3-Dodecyloxy-2,4,5-trifluoro-6-nitro-phenol | CHEM...)Show SMILES CCCCCCCCCCCCOc1c(F)c(O)c(c(F)c1F)[N+]([O-])=O Show InChI InChI=1S/C18H26F3NO4/c1-2-3-4-5-6-7-8-9-10-11-12-26-18-14(20)13(19)16(22(24)25)17(23)15(18)21/h23H,2-12H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 9: 623-6 (1999)
BindingDB Entry DOI: 10.7270/Q28P5ZN0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus (rat)) | BDBM50075442
(3-Allyloxy-2,4,5-trifluoro-6-nitro-phenol | CHEMBL...)Show InChI InChI=1S/C9H6F3NO4/c1-2-3-17-9-5(11)4(10)7(13(15)16)8(14)6(9)12/h2,14H,1,3H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 9: 623-6 (1999)
BindingDB Entry DOI: 10.7270/Q28P5ZN0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus (rat)) | BDBM50075438
(3-(Biphenyl-4-ylmethoxy)-2,4,5-trifluoro-6-nitro-p...)Show SMILES Oc1c(F)c(OCc2ccc(cc2)-c2ccccc2)c(F)c(F)c1[N+]([O-])=O Show InChI InChI=1S/C19H12F3NO4/c20-14-15(21)19(16(22)18(24)17(14)23(25)26)27-10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9,24H,10H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 9: 623-6 (1999)
BindingDB Entry DOI: 10.7270/Q28P5ZN0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus (rat)) | BDBM50075441
(2,4,5-Trifluoro-3-(naphthalen-2-ylmethoxy)-6-nitro...)Show SMILES Oc1c(F)c(OCc2ccc3ccccc3c2)c(F)c(F)c1[N+]([O-])=O Show InChI InChI=1S/C17H10F3NO4/c18-12-13(19)17(14(20)16(22)15(12)21(23)24)25-8-9-5-6-10-3-1-2-4-11(10)7-9/h1-7,22H,8H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 9: 623-6 (1999)
BindingDB Entry DOI: 10.7270/Q28P5ZN0 |
More data for this
Ligand-Target Pair | |
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