Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 3A4/3A43/3A5/3A7 (Homo sapiens (Human)) | BDBM50464556 (CHEMBL4289811 | US10464907, Compound 21f | US10889...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Keimyung University Curated by ChEMBL | Assay Description Inhibition of CYP3A in human pooled human liver microsomes using midazolam as substrate assessed as midazolam 1'-hydroxylation preincubated for 5 min... | Eur J Med Chem 143: 390-401 (2018) Article DOI: 10.1016/j.ejmech.2017.11.054 BindingDB Entry DOI: 10.7270/Q29C713M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4/3A43/3A5/3A7 (Homo sapiens (Human)) | BDBM50508419 (CHEMBL4471264) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology Curated by ChEMBL | Assay Description Inhibition of CYP3A in human liver microsomes assessed as reduction in midazolam 1'-hydroxylation by tandem mass spectrometry analysis | J Med Chem 62: 575-588 (2019) Article DOI: 10.1021/acs.jmedchem.8b01168 BindingDB Entry DOI: 10.7270/Q2QZ2F8H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4/3A43/3A5/3A7 (Homo sapiens (Human)) | BDBM50527104 (CHEMBL4447583) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >6.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Lindsley F. Kimball Research Institute Curated by ChEMBL | Assay Description Inhibition of CYP3A in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 ... | J Med Chem 63: 1724-1749 (2020) Article DOI: 10.1021/acs.jmedchem.9b02149 BindingDB Entry DOI: 10.7270/Q2X63RC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4/3A43/3A5/3A7 (Homo sapiens (Human)) | BDBM50527104 (CHEMBL4447583) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Lindsley F. Kimball Research Institute Curated by ChEMBL | Assay Description Inhibition of CYP3A in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to ... | J Med Chem 63: 1724-1749 (2020) Article DOI: 10.1021/acs.jmedchem.9b02149 BindingDB Entry DOI: 10.7270/Q2X63RC7 | |||||||||||
More data for this Ligand-Target Pair |