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Compile Data Set for Download or QSAR

Found 1 hit of ic50 for UniProtKB: P42345   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Regulatory-associated protein of mTOR/Serine/threonine-protein kinase mTOR/Target of rapamycin complex subunit LST8


(Homo sapiens (Human))		BDBM50490555
PNG
(CHEMBL2338395)
Show SMILES [H][C@]12CC[C@]([H])(C[C@H](C1)c1nc3c(cnn3c3[nH]ncc13)-c1ccc(nc1)-c1ccccc1)N2C(=O)c1nnc[nH]1 |r|
Show InChI InChI=1S/C28H24N10O/c39-28(25-30-15-32-35-25)37-19-7-8-20(37)11-18(10-19)24-22-13-31-36-27(22)38-26(34-24)21(14-33-38)17-6-9-23(29-12-17)16-4-2-1-3-5-16/h1-6,9,12-15,18-20H,7-8,10-11H2,(H,31,36)(H,30,32,35)/t18-,19-,20+
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of mTORC1 in human PC3 cells assessed as reduction in phosphorylated 4E-BP1Thr37/46 level after 90 mins by immunofluorescence assay

ACS Med Chem Lett 4: 321-2 (2013)


Article DOI: 10.1021/ml400056x
BindingDB Entry DOI: 10.7270/Q2TM7F1R
More data for this
Ligand-Target Pair