Found 41 hits of ic50 for UniProtKB: P24864 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258888
(US9499492, 40)Show SMILES C[S@](=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N |r| Show InChI InChI=1S/C19H13BrF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28)/t30-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258868
(US9499492, 20)Show SMILES COc1cc(CS(C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C20H16F3N5O2S/c1-30-15-6-12(10-31(2,29)26-11-24)5-14(8-15)27-20-25-9-18(23)19(28-20)16-4-3-13(21)7-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258871
(US9499492, 23)Show SMILES C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O |r| Show InChI InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30)/t34-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258867
(US9499492, 19)Show SMILES CS(=N)(=O)Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C18H14BrF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258883
(US9499492, 35)Show SMILES Cc1cc(C[S@@](C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 |r| Show InChI InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258884
(US9499492, 36)Show SMILES Cc1cc(C[S@](C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 |r| Show InChI InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28)/t30-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258887
(US9499492, 39)Show SMILES C[S@@](=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N |r| Show InChI InChI=1S/C19H13BrF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258864
(US9499492, 16)Show SMILES Cc1cc(CS(C)(=O)=NC#N)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C20H16F3N5OS/c1-12-5-13(10-30(2,29)26-11-24)7-15(6-12)27-20-25-9-18(23)19(28-20)16-4-3-14(21)8-17(16)22/h3-9H,10H2,1-2H3,(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258866
(US9499492, 18)Show SMILES CS(=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N Show InChI InChI=1S/C19H13BrF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258890
(US9499492, 42)Show SMILES C[S@](=N)(=O)Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 |r| Show InChI InChI=1S/C18H14BrF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258865
(US9499492, 17)Show SMILES Cc1cc(CS(C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258889
(US9499492, 41)Show SMILES C[S@@](=N)(=O)Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 |r| Show InChI InChI=1S/C18H14BrF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 509 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258862
(US9499492, 14)Show SMILES CS(=O)(Cc1cc(Cl)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N Show InChI InChI=1S/C19H13ClF3N5OS/c1-30(29,26-10-24)9-11-4-12(20)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258856
(US9499492, 8)Show SMILES CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C21H19F3N4O3S/c1-3-31-21(29)28-32(2,30)12-13-5-4-6-15(9-13)26-20-25-11-18(24)19(27-20)16-8-7-14(22)10-17(16)23/h4-11H,3,12H2,1-2H3,(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258858
(US9499492, 10)Show SMILES CS(=O)(Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N Show InChI InChI=1S/C19H13F4N5OS/c1-30(29,26-10-24)9-11-4-13(21)6-14(5-11)27-19-25-8-17(23)18(28-19)15-3-2-12(20)7-16(15)22/h2-8H,9H2,1H3,(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258854
(US9499492, 6)Show SMILES C[S@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29)/t31-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258863
(US9499492, 15)Show SMILES CS(=N)(=O)Cc1cc(Cl)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C18H14ClF3N4OS/c1-28(23,27)9-10-4-11(19)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-12(20)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258872
(US9499492, 24)Show SMILES C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O |r| Show InChI InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30)/t34-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258886
(US9499492, 38)Show SMILES Cc1cc(C[S@@](C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 |r| Show InChI InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26)/t28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258861
(US9499492, 13)Show SMILES C[S@](=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 |r| Show InChI InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258853
(US9499492, 5)Show SMILES C[S@@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29)/t31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258885
(US9499492, 37)Show SMILES Cc1cc(C[S@](C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 |r| Show InChI InChI=1S/C19H17F3N4OS/c1-11-5-12(10-28(2,23)27)7-14(6-11)25-19-24-9-17(22)18(26-19)15-4-3-13(20)8-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 830 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258852
(US9499492, 4)Show SMILES CS(=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F Show InChI InChI=1S/C19H14F6N4OS/c1-31(26,30)9-10-4-11(19(23,24)25)6-13(5-10)28-18-27-8-16(22)17(29-18)14-3-2-12(20)7-15(14)21/h2-8,26H,9H2,1H3,(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258879
(US9499492, 31)Show SMILES C[S@@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F |r| Show InChI InChI=1S/C18H14F8N4OS2/c1-32(27,31)9-10-4-12(7-13(5-10)33(22,23,24,25)26)29-18-28-8-16(21)17(30-18)14-3-2-11(19)6-15(14)20/h2-8,27H,9H2,1H3,(H,28,29,30)/t32-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258859
(US9499492, 11)Show SMILES CS(=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258877
(US9499492, 29)Show SMILES C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N |r| Show InChI InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32)/t34-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258875
(US9499492, 27)Show SMILES NCC[S@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F6N5OS/c21-13-1-2-15(16(22)8-13)18-17(23)9-29-19(31-18)30-14-6-11(10-33(28,32)4-3-27)5-12(7-14)20(24,25)26/h1-2,5-9,28H,3-4,10,27H2,(H,29,30,31)/t33-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258857
(US9499492, 9)Show SMILES CS(=N)(=O)Cc1cccc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C18H15F3N4OS/c1-27(22,26)10-11-3-2-4-13(7-11)24-18-23-9-16(21)17(25-18)14-6-5-12(19)8-15(14)20/h2-9,22H,10H2,1H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258855
(US9499492, 7)Show SMILES CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC(N)=O Show InChI InChI=1S/C20H15F6N5O2S/c1-34(33,31-18(27)32)9-10-4-11(20(24,25)26)6-13(5-10)29-19-28-8-16(23)17(30-19)14-3-2-12(21)7-15(14)22/h2-8H,9H2,1H3,(H2,27,32)(H,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258869
(US9499492, 21)Show SMILES COc1cc(CS(C)(=N)=O)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 Show InChI InChI=1S/C19H17F3N4O2S/c1-28-14-6-11(10-29(2,23)27)5-13(8-14)25-19-24-9-17(22)18(26-19)15-4-3-12(20)7-16(15)21/h3-9,23H,10H2,1-2H3,(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258870
(US9499492, 22)Show SMILES COCCS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N Show InChI InChI=1S/C22H17F6N5O2S/c1-35-4-5-36(34,31-12-29)11-13-6-14(22(26,27)28)8-16(7-13)32-21-30-10-19(25)20(33-21)17-3-2-15(23)9-18(17)24/h2-3,6-10H,4-5,11H2,1H3,(H,30,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258850
(US9499492, 2)Show SMILES C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N |r| Show InChI InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31)/t33-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258874
(US9499492, 26)Show SMILES NCC[S@@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C20H17F6N5OS/c21-13-1-2-15(16(22)8-13)18-17(23)9-29-19(31-18)30-14-6-11(10-33(28,32)4-3-27)5-12(7-14)20(24,25)26/h1-2,5-9,28H,3-4,10,27H2,(H,29,30,31)/t33-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258876
(US9499492, 28)Show SMILES CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N Show InChI InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258851
(US9499492, 3)Show SMILES C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N |r| Show InChI InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31)/t33-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258849
(US9499492, 1)Show SMILES CS(=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F)=NC#N Show InChI InChI=1S/C20H13F6N5OS/c1-33(32,29-10-27)9-11-4-12(20(24,25)26)6-14(5-11)30-19-28-8-17(23)18(31-19)15-3-2-13(21)7-16(15)22/h2-8H,9H2,1H3,(H,28,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258878
(US9499492, 30)Show SMILES C[S@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC#N |r| Show InChI InChI=1S/C19H13F8N5OS2/c1-34(33,30-10-28)9-11-4-13(7-14(5-11)35(23,24,25,26)27)31-19-29-8-17(22)18(32-19)15-3-2-12(20)6-16(15)21/h2-8H,9H2,1H3,(H,29,31,32)/t34-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258881
(US9499492, 33)Show SMILES C[S@@](=O)(Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F)=NC(N)=O |r| Show InChI InChI=1S/C19H15F8N5O2S2/c1-35(34,32-18(28)33)9-10-4-12(7-13(5-10)36(23,24,25,26)27)30-19-29-8-16(22)17(31-19)14-3-2-11(20)6-15(14)21/h2-8H,9H2,1H3,(H2,28,33)(H,29,30,31)/t35-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258880
(US9499492, 32)Show SMILES C[S@](=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)S(F)(F)(F)(F)F |r| Show InChI InChI=1S/C18H14F8N4OS2/c1-32(27,31)9-10-4-12(7-13(5-10)33(22,23,24,25)26)29-18-28-8-16(21)17(30-18)14-3-2-11(19)6-15(14)20/h2-8,27H,9H2,1H3,(H,28,29,30)/t32-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258860
(US9499492, 12)Show SMILES C[S@@](=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1 |r| Show InChI InChI=1S/C18H14F4N4OS/c1-28(23,27)9-10-4-12(20)6-13(5-10)25-18-24-8-16(22)17(26-18)14-3-2-11(19)7-15(14)21/h2-8,23H,9H2,1H3,(H,24,25,26)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P
(Homo sapiens (Human)) | BDBM258873
(US9499492, 25)Show SMILES NCCS(=N)(=O)Cc1cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)cc(c1)C(F)(F)F Show InChI InChI=1S/C20H17F6N5OS/c21-13-1-2-15(16(22)8-13)18-17(23)9-29-19(31-18)30-14-6-11(10-33(28,32)4-3-27)5-12(7-14)20(24,25)26/h1-2,5-9,28H,3-4,10,27H2,(H,29,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | 8.0 | 22 |
Bayer Pharma Aktiengesellschaft
US Patent
| Assay Description
Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep... |
US Patent US9499492 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GW0 |
More data for this
Ligand-Target Pair | |
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