Found 51 hits of ic50 for UniProtKB: P54750 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473071
(CHEMBL145499)Show SMILES CC(=O)Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc(Cl)c(N)c(Cl)c1)C3=O)c1ccccc1 |c:15| Show InChI InChI=1S/C26H21Cl2N5O3/c1-13(34)30-17-9-15-7-8-33-23(15)18(12-17)22(14-5-3-2-4-6-14)31-24(26(33)36)32-25(35)16-10-19(27)21(29)20(28)11-16/h2-6,9-12,24H,7-8,29H2,1H3,(H,30,34)(H,32,35)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473077
(CHEMBL144258)Show SMILES CN(C)c1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc(Cl)c(N)c(Cl)c1)C3=O)c1ccccc1 |c:14| Show InChI InChI=1S/C26H23Cl2N5O2/c1-32(2)17-10-15-8-9-33-23(15)18(13-17)22(14-6-4-3-5-7-14)30-24(26(33)35)31-25(34)16-11-19(27)21(29)20(28)12-16/h3-7,10-13,24H,8-9,29H2,1-2H3,(H,31,34)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473073
(CHEMBL436207)Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1nnc2cc(C)nn2c1C)C3=O)c1ccccc1 |c:13| Show InChI InChI=1S/C26H23N7O3/c1-14-11-20-29-30-21(15(2)33(20)31-14)25(34)28-24-26(35)32-10-9-17-12-18(36-3)13-19(23(17)32)22(27-24)16-7-5-4-6-8-16/h4-8,11-13,24H,9-10H2,1-3H3,(H,28,34)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473088
(CHEMBL434838)Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cnc2ccccc2c1)C3=O)c1ccccc1 |c:13| Show InChI InChI=1S/C28H22N4O3/c1-35-21-14-19-11-12-32-25(19)22(15-21)24(17-7-3-2-4-8-17)30-26(28(32)34)31-27(33)20-13-18-9-5-6-10-23(18)29-16-20/h2-10,13-16,26H,11-12H2,1H3,(H,31,33)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50223646
(CHEMBL418848)Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1 |c:13| Show InChI InChI=1S/C24H20N4O3/c1-31-18-13-17-9-12-28-21(17)19(14-18)20(15-5-3-2-4-6-15)26-22(24(28)30)27-23(29)16-7-10-25-11-8-16/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473072
(CHEMBL357197)Show SMILES CC(=O)Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1 |c:15| Show InChI InChI=1S/C25H21N5O3/c1-15(31)27-19-13-18-9-12-30-22(18)20(14-19)21(16-5-3-2-4-6-16)28-23(25(30)33)29-24(32)17-7-10-26-11-8-17/h2-8,10-11,13-14,23H,9,12H2,1H3,(H,27,31)(H,29,32)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473078
(CHEMBL341662)Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cc(cc3CCN(c23)C1=O)N1CCCC1)c1ccncc1 |t:4| Show InChI InChI=1S/C27H25N5O2/c33-26(19-8-11-28-12-9-19)30-25-27(34)32-15-10-20-16-21(31-13-4-5-14-31)17-22(24(20)32)23(29-25)18-6-2-1-3-7-18/h1-3,6-9,11-12,16-17,25H,4-5,10,13-15H2,(H,30,33)/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473087
(CHEMBL341671)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1c(Cl)cncc1Cl)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C24H18Cl2N4O2/c1-13-9-15-7-8-30-21(15)16(10-13)20(14-5-3-2-4-6-14)28-22(24(30)32)29-23(31)19-17(25)11-27-12-18(19)26/h2-6,9-12,22H,7-8H2,1H3,(H,29,31)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473089
(CHEMBL145390)Show SMILES Nc1c(Cl)cc(cc1Cl)C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(cc3CCN(c23)C1=O)N1CCCC1 |t:14| Show InChI InChI=1S/C28H25Cl2N5O2/c29-21-13-18(14-22(30)23(21)31)27(36)33-26-28(37)35-11-8-17-12-19(34-9-4-5-10-34)15-20(25(17)35)24(32-26)16-6-2-1-3-7-16/h1-3,6-7,12-15,26H,4-5,8-11,31H2,(H,33,36)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.92E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217549
(CHEMBL332853)Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccc(Cl)cc1)C3=O)c1ccccc1 |c:13| Show InChI InChI=1S/C25H20ClN3O3/c1-32-19-13-17-11-12-29-22(17)20(14-19)21(15-5-3-2-4-6-15)27-23(25(29)31)28-24(30)16-7-9-18(26)10-8-16/h2-10,13-14,23H,11-12H2,1H3,(H,28,30)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217553
(CHEMBL339749)Show SMILES COc1ccccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(C)cc3CCN(c23)C1=O |t:13| Show InChI InChI=1S/C26H23N3O3/c1-16-14-18-12-13-29-23(18)20(15-16)22(17-8-4-3-5-9-17)27-24(26(29)31)28-25(30)19-10-6-7-11-21(19)32-2/h3-11,14-15,24H,12-13H2,1-2H3,(H,28,30)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473086
(CHEMBL357616)Show SMILES CC(C)(C)OC(=O)Nc1cnccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O |t:19| Show InChI InChI=1S/C28H27N5O4/c1-28(2,3)37-27(36)30-21-16-29-14-12-19(21)25(34)32-24-26(35)33-15-13-18-10-7-11-20(23(18)33)22(31-24)17-8-5-4-6-9-17/h4-12,14,16,24H,13,15H2,1-3H3,(H,30,36)(H,32,34)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217560
(CHEMBL126581)Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc2ccccc2cn1)C3=O)c1ccccc1 |c:13| Show InChI InChI=1S/C28H22N4O3/c1-35-21-13-19-11-12-32-25(19)22(15-21)24(17-7-3-2-4-8-17)30-26(28(32)34)31-27(33)23-14-18-9-5-6-10-20(18)16-29-23/h2-10,13-16,26H,11-12H2,1H3,(H,31,33)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217560
(CHEMBL126581)Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc2ccccc2cn1)C3=O)c1ccccc1 |c:13| Show InChI InChI=1S/C28H22N4O3/c1-35-21-13-19-11-12-32-25(19)22(15-21)24(17-7-3-2-4-8-17)30-26(28(32)34)31-27(33)23-14-18-9-5-6-10-20(18)16-29-23/h2-10,13-16,26H,11-12H2,1H3,(H,31,33)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473080
(CHEMBL423931)Show SMILES CC(C)(C)OC(=O)Nc1cnccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(N)cc3CCN(c23)C1=O |t:19| Show InChI InChI=1S/C28H28N6O4/c1-28(2,3)38-27(37)31-21-15-30-11-9-19(21)25(35)33-24-26(36)34-12-10-17-13-18(29)14-20(23(17)34)22(32-24)16-7-5-4-6-8-16/h4-9,11,13-15,24H,10,12,29H2,1-3H3,(H,31,37)(H,33,35)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.77E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217553
(CHEMBL339749)Show SMILES COc1ccccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(C)cc3CCN(c23)C1=O |t:13| Show InChI InChI=1S/C26H23N3O3/c1-16-14-18-12-13-29-23(18)20(15-16)22(17-8-4-3-5-9-17)27-24(26(29)31)28-25(30)19-10-6-7-11-21(19)32-2/h3-11,14-15,24H,12-13H2,1-2H3,(H,28,30)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473092
(CHEMBL144245)Show SMILES Cc1cc2nnc(C(=O)N[C@@H]3N=C(c4ccccc4)c4cc(N)cc5CCN(c45)C3=O)c(C)n2n1 |t:11| Show InChI InChI=1S/C25H22N8O2/c1-13-10-19-29-30-20(14(2)33(19)31-13)24(34)28-23-25(35)32-9-8-16-11-17(26)12-18(22(16)32)21(27-23)15-6-4-3-5-7-15/h3-7,10-12,23H,8-9,26H2,1-2H3,(H,28,34)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217550
(CHEMBL111925 | CI-1018)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1 |r,c:12| Show InChI InChI=1S/C24H20N4O2/c1-15-13-18-9-12-28-21(18)19(14-15)20(16-5-3-2-4-6-16)26-22(24(28)30)27-23(29)17-7-10-25-11-8-17/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
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antibodypedia
antibodypedia
antibodypedia
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| Purchase
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Similars
| Article
PubMed
| n/a | n/a | 7.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473081
(CHEMBL144404)Show SMILES Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cnc2ccccc2c1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C27H21N5O2/c28-20-13-18-10-11-32-24(18)21(14-20)23(16-6-2-1-3-7-16)30-25(27(32)34)31-26(33)19-12-17-8-4-5-9-22(17)29-15-19/h1-9,12-15,25H,10-11,28H2,(H,31,33)/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473084
(CHEMBL434516)Show SMILES COc1ccccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(N)cc3CCN(c23)C1=O |t:13| Show InChI InChI=1S/C25H22N4O3/c1-32-20-10-6-5-9-18(20)24(30)28-23-25(31)29-12-11-16-13-17(26)14-19(22(16)29)21(27-23)15-7-3-2-4-8-15/h2-10,13-14,23H,11-12,26H2,1H3,(H,28,30)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473082
(CHEMBL144570)Show SMILES Nc1ccc(cc1)C(=O)N[C@@H]1N=C(c2ccccc2)c2cc(N)cc3CCN(c23)C1=O |t:12| Show InChI InChI=1S/C24H21N5O2/c25-17-8-6-15(7-9-17)23(30)28-22-24(31)29-11-10-16-12-18(26)13-19(21(16)29)20(27-22)14-4-2-1-3-5-14/h1-9,12-13,22H,10-11,25-26H2,(H,28,30)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
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| Article
PubMed
| n/a | n/a | 9.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473075
(CHEMBL343243)Show SMILES Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1N)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C23H20N6O2/c24-15-10-14-7-9-29-20(14)17(11-15)19(13-4-2-1-3-5-13)27-21(23(29)31)28-22(30)16-6-8-26-12-18(16)25/h1-6,8,10-12,21H,7,9,24-25H2,(H,28,30)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50223647
(CHEMBL112366)Show SMILES Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C23H19N5O2/c24-17-12-16-8-11-28-20(16)18(13-17)19(14-4-2-1-3-5-14)26-21(23(28)30)27-22(29)15-6-9-25-10-7-15/h1-7,9-10,12-13,21H,8,11,24H2,(H,27,29)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
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PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217561
(CHEMBL340860)Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc2ccccc2[nH]1)C3=O)c1ccccc1 |c:13| Show InChI InChI=1S/C27H22N4O3/c1-34-19-13-18-11-12-31-24(18)20(15-19)23(16-7-3-2-4-8-16)29-25(27(31)33)30-26(32)22-14-17-9-5-6-10-21(17)28-22/h2-10,13-15,25,28H,11-12H2,1H3,(H,30,32)/t25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217555
(CHEMBL332854)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccc(Cl)cc1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C25H20ClN3O2/c1-15-13-18-11-12-29-22(18)20(14-15)21(16-5-3-2-4-6-16)27-23(25(29)31)28-24(30)17-7-9-19(26)10-8-17/h2-10,13-14,23H,11-12H2,1H3,(H,28,30)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217546
(CHEMBL125123)Show SMILES Cc1cc2nnc(C(=O)N[C@@H]3N=C(c4ccccc4)c4cc(C)cc5CCN(c45)C3=O)c(C)n2n1 |t:11| Show InChI InChI=1S/C26H23N7O2/c1-14-11-18-9-10-32-23(18)19(12-14)22(17-7-5-4-6-8-17)27-24(26(32)35)28-25(34)21-16(3)33-20(29-30-21)13-15(2)31-33/h4-8,11-13,24H,9-10H2,1-3H3,(H,28,34)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473076
(CHEMBL144605)Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1ccncc1 |t:4| Show InChI InChI=1S/C23H18N4O2/c28-22(17-9-12-24-13-10-17)26-21-23(29)27-14-11-16-7-4-8-18(20(16)27)19(25-21)15-5-2-1-3-6-15/h1-10,12-13,21H,11,14H2,(H,26,28)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217563
(CHEMBL125671)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc(Cl)c(N)c(Cl)c1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C25H20Cl2N4O2/c1-13-9-15-7-8-31-22(15)17(10-13)21(14-5-3-2-4-6-14)29-23(25(31)33)30-24(32)16-11-18(26)20(28)19(27)12-16/h2-6,9-12,23H,7-8,28H2,1H3,(H,30,32)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217546
(CHEMBL125123)Show SMILES Cc1cc2nnc(C(=O)N[C@@H]3N=C(c4ccccc4)c4cc(C)cc5CCN(c45)C3=O)c(C)n2n1 |t:11| Show InChI InChI=1S/C26H23N7O2/c1-14-11-18-9-10-32-23(18)19(12-14)22(17-7-5-4-6-8-17)27-24(26(32)35)28-25(34)21-16(3)33-20(29-30-21)13-15(2)31-33/h4-8,11-13,24H,9-10H2,1-3H3,(H,28,34)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217547
(CHEMBL338657)Show SMILES O=C(N[C@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2[nH]1 |t:4| Show InChI InChI=1S/C26H20N4O2/c31-25(21-15-18-9-4-5-12-20(18)27-21)29-24-26(32)30-14-13-17-10-6-11-19(23(17)30)22(28-24)16-7-2-1-3-8-16/h1-12,15,24,27H,13-14H2,(H,29,31)/t24-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473070
(CHEMBL422653)Show SMILES Cc1cc2nnc(C(=O)N[C@@H]3N=C(c4ccccc4)c4cc(cc5CCN(c45)C3=O)N3CCCC3)c(C)n2n1 |t:11| Show InChI InChI=1S/C29H28N8O2/c1-17-14-23-32-33-24(18(2)37(23)34-17)28(38)31-27-29(39)36-13-10-20-15-21(35-11-6-7-12-35)16-22(26(20)36)25(30-27)19-8-4-3-5-9-19/h3-5,8-9,14-16,27H,6-7,10-13H2,1-2H3,(H,31,38)/t27-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217556
(CHEMBL125828)Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1 | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217550
(CHEMBL111925 | CI-1018)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1 |r,c:12| Show InChI InChI=1S/C24H20N4O2/c1-15-13-18-9-12-28-21(18)19(14-15)20(16-5-3-2-4-6-16)26-22(24(28)30)27-23(29)17-7-10-25-11-8-17/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1 | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217563
(CHEMBL125671)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc(Cl)c(N)c(Cl)c1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C25H20Cl2N4O2/c1-13-9-15-7-8-31-22(15)17(10-13)21(14-5-3-2-4-6-14)29-23(25(31)33)30-24(32)16-11-18(26)20(28)19(27)12-16/h2-6,9-12,23H,7-8,28H2,1H3,(H,30,32)/t23-/m0/s1 | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217562
(CHEMBL420335)Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2[nH]1 |t:4| Show InChI InChI=1S/C26H20N4O2/c31-25(21-15-18-9-4-5-12-20(18)27-21)29-24-26(32)30-14-13-17-10-6-11-19(23(17)30)22(28-24)16-7-2-1-3-8-16/h1-12,15,24,27H,13-14H2,(H,29,31)/t24-/m0/s1 | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473074
(CHEMBL356548)Show SMILES Nc1cnccc1C(=O)N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O |t:12| Show InChI InChI=1S/C23H19N5O2/c24-18-13-25-11-9-16(18)22(29)27-21-23(30)28-12-10-15-7-4-8-17(20(15)28)19(26-21)14-5-2-1-3-6-14/h1-9,11,13,21H,10,12,24H2,(H,27,29)/t21-/m0/s1 | PDB
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Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217551
(CHEMBL419791)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccc(Cl)cc1Cl)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C25H19Cl2N3O2/c1-14-11-16-9-10-30-22(16)19(12-14)21(15-5-3-2-4-6-15)28-23(25(30)32)29-24(31)18-8-7-17(26)13-20(18)27/h2-8,11-13,23H,9-10H2,1H3,(H,29,31)/t23-/m0/s1 | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473090
(CHEMBL144287)Show SMILES Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1c(Cl)cncc1Cl)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C23H17Cl2N5O2/c24-16-10-27-11-17(25)18(16)22(31)29-21-23(32)30-7-6-13-8-14(26)9-15(20(13)30)19(28-21)12-4-2-1-3-5-12/h1-5,8-11,21H,6-7,26H2,(H,29,31)/t21-/m0/s1 | PDB
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Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217559
(CHEMBL123266)Show SMILES Oc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc2ccccc2cn1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C27H20N4O3/c32-20-12-18-10-11-31-24(18)21(14-20)23(16-6-2-1-3-7-16)29-25(27(31)34)30-26(33)22-13-17-8-4-5-9-19(17)15-28-22/h1-9,12-15,25,32H,10-11H2,(H,30,33)/t25-/m0/s1 | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217545
(CHEMBL341304)Show SMILES Nc1c(Cl)cc(cc1Cl)C(=O)N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O |t:14| Show InChI InChI=1S/C24H18Cl2N4O2/c25-17-11-15(12-18(26)19(17)27)23(31)29-22-24(32)30-10-9-14-7-4-8-16(21(14)30)20(28-22)13-5-2-1-3-6-13/h1-8,11-12,22H,9-10,27H2,(H,29,31)/t22-/m0/s1 | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217556
(CHEMBL125828)Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cc2ccccc2cn1 |t:4| Show InChI InChI=1S/C27H20N4O2/c32-26(22-15-19-9-4-5-10-20(19)16-28-22)30-25-27(33)31-14-13-18-11-6-12-21(24(18)31)23(29-25)17-7-2-1-3-8-17/h1-12,15-16,25H,13-14H2,(H,30,32)/t25-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217557
(CHEMBL123782)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C25H19Cl2N3O2/c1-14-9-16-7-8-30-22(16)20(10-14)21(15-5-3-2-4-6-15)28-23(25(30)32)29-24(31)17-11-18(26)13-19(27)12-17/h2-6,9-13,23H,7-8H2,1H3,(H,29,31)/t23-/m0/s1 | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473083
(CHEMBL342285 | CI-1044)Show SMILES Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cccnc1)C3=O)c1ccccc1 |r,c:12| Show InChI InChI=1S/C23H19N5O2/c24-17-11-15-8-10-28-20(15)18(12-17)19(14-5-2-1-3-6-14)26-21(23(28)30)27-22(29)16-7-4-9-25-13-16/h1-7,9,11-13,21H,8,10,24H2,(H,27,29)/t21-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217552
(CHEMBL339408)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc2ccccc2cn1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C28H22N4O2/c1-17-13-20-11-12-32-25(20)22(14-17)24(18-7-3-2-4-8-18)30-26(28(32)34)31-27(33)23-15-19-9-5-6-10-21(19)16-29-23/h2-10,13-16,26H,11-12H2,1H3,(H,31,33)/t26-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473068
(CHEMBL422828)Show SMILES Clc1cncc(Cl)c1C(=O)N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O |t:13| Show InChI InChI=1S/C23H16Cl2N4O2/c24-16-11-26-12-17(25)18(16)22(30)28-21-23(31)29-10-9-14-7-4-8-15(20(14)29)19(27-21)13-5-2-1-3-6-13/h1-8,11-12,21H,9-10H2,(H,28,30)/t21-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217548
(CHEMBL333585)Show SMILES O=C(NC1N=C(c2ccccc2)c2cccc3CCCN(c23)C1=O)c1cc2ccccc2[nH]1 |t:4| Show InChI InChI=1S/C27H22N4O2/c32-26(22-16-19-10-4-5-14-21(19)28-22)30-25-27(33)31-15-7-12-18-11-6-13-20(24(18)31)23(29-25)17-8-2-1-3-9-17/h1-6,8-11,13-14,16,25,28H,7,12,15H2,(H,30,32) | PDB
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Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473085
(CHEMBL146218)Show SMILES Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc(Cl)c(N)c(Cl)c1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C24H19Cl2N5O2/c25-17-9-14(10-18(26)19(17)28)23(32)30-22-24(33)31-7-6-13-8-15(27)11-16(21(13)31)20(29-22)12-4-2-1-3-5-12/h1-5,8-11,22H,6-7,27-28H2,(H,30,32)/t22-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50473069
(CHEMBL144370)Show SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cccc3CCN(c23)C1=O)c1cccnc1 |t:4| Show InChI InChI=1S/C23H18N4O2/c28-22(17-9-5-12-24-14-17)26-21-23(29)27-13-11-16-8-4-10-18(20(16)27)19(25-21)15-6-2-1-3-7-15/h1-10,12,14,21H,11,13H2,(H,26,28)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. |
J Med Chem 43: 4850-67 (2000)
Article DOI: 10.1021/jm000315p
BindingDB Entry DOI: 10.7270/Q25M68FS |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50217552
(CHEMBL339408)Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc2ccccc2cn1)C3=O)c1ccccc1 |c:12| Show InChI InChI=1S/C28H22N4O2/c1-17-13-20-11-12-32-25(20)22(14-17)24(18-7-3-2-4-8-18)30-26(28(32)34)31-27(33)23-15-19-9-5-6-10-21(19)16-29-23/h2-10,13-16,26H,11-12H2,1H3,(H,31,33)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Jouveinal-Parke Davis
Curated by ChEMBL
| Assay Description
Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [... |
Bioorg Med Chem Lett 10: 35-8 (2000)
BindingDB Entry DOI: 10.7270/Q25Q4Z9J |
More data for this
Ligand-Target Pair | |
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