Compile Data Set for Download or QSAR

Found 8 hits of ic50 for UniProtKB: P49759   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50239782 (CHEMBL4082113) Show SMILES COc1ccc2sc(cc2c1)C(=O)N(C)Cc1cccc(F)c1 Show InChI InChI=1S/C18H16FNO2S/c1-20(11-12-4-3-5-14(19)8-12)18(21)17-10-13-9-15(22-2)6-7-16(13)23-17/h3-10H,11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of CLK1/4 in human T24 cells assessed as down regulation of EGFR expression after 3 days by Western blot analysis				J Med Chem 60: 5377-5391 (2017) Article DOI: 10.1021/acs.jmedchem.6b01915 BindingDB Entry DOI: 10.7270/Q2862JMM
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50239782 (CHEMBL4082113) Show SMILES COc1ccc2sc(cc2c1)C(=O)N(C)Cc1cccc(F)c1 Show InChI InChI=1S/C18H16FNO2S/c1-20(11-12-4-3-5-14(19)8-12)18(21)17-10-13-9-15(22-2)6-7-16(13)23-17/h3-10H,11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of CLK1/4 in human MDA-MB-231 cells assessed as down regulation of EGFR expression after 3 days by Western blot analysis				J Med Chem 60: 5377-5391 (2017) Article DOI: 10.1021/acs.jmedchem.6b01915 BindingDB Entry DOI: 10.7270/Q2862JMM
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50239782 (CHEMBL4082113) Show SMILES COc1ccc2sc(cc2c1)C(=O)N(C)Cc1cccc(F)c1 Show InChI InChI=1S/C18H16FNO2S/c1-20(11-12-4-3-5-14(19)8-12)18(21)17-10-13-9-15(22-2)6-7-16(13)23-17/h3-10H,11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of CLK1/4 in human T24 cells assessed as down regulation of HDAC1 expression after 3 days by Western blot analysis				J Med Chem 60: 5377-5391 (2017) Article DOI: 10.1021/acs.jmedchem.6b01915 BindingDB Entry DOI: 10.7270/Q2862JMM
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50239787 (CHEMBL4094143) Show SMILES COc1ccc2sc(cc2c1)C(=O)NCc1cccc(F)c1 Show InChI InChI=1S/C17H14FNO2S/c1-21-14-5-6-15-12(8-14)9-16(22-15)17(20)19-10-11-3-2-4-13(18)7-11/h2-9H,10H2,1H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of CLK1/4 in human T24 cells assessed as down regulation of HDAC1 expression after 3 days by Western blot analysis				J Med Chem 60: 5377-5391 (2017) Article DOI: 10.1021/acs.jmedchem.6b01915 BindingDB Entry DOI: 10.7270/Q2862JMM
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50239787 (CHEMBL4094143) Show SMILES COc1ccc2sc(cc2c1)C(=O)NCc1cccc(F)c1 Show InChI InChI=1S/C17H14FNO2S/c1-21-14-5-6-15-12(8-14)9-16(22-15)17(20)19-10-11-3-2-4-13(18)7-11/h2-9H,10H2,1H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of CLK1/4 in human T24 cells assessed as down regulation of EGFR expression after 3 days by Western blot analysis				J Med Chem 60: 5377-5391 (2017) Article DOI: 10.1021/acs.jmedchem.6b01915 BindingDB Entry DOI: 10.7270/Q2862JMM
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50239782 (CHEMBL4082113) Show SMILES COc1ccc2sc(cc2c1)C(=O)N(C)Cc1cccc(F)c1 Show InChI InChI=1S/C18H16FNO2S/c1-20(11-12-4-3-5-14(19)8-12)18(21)17-10-13-9-15(22-2)6-7-16(13)23-17/h3-10H,11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of CLK1/4 in human MDA-MB-231 cells assessed as down regulation of S6 kinase expression after 3 days by Western blot analysis				J Med Chem 60: 5377-5391 (2017) Article DOI: 10.1021/acs.jmedchem.6b01915 BindingDB Entry DOI: 10.7270/Q2862JMM
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50239787 (CHEMBL4094143) Show SMILES COc1ccc2sc(cc2c1)C(=O)NCc1cccc(F)c1 Show InChI InChI=1S/C17H14FNO2S/c1-21-14-5-6-15-12(8-14)9-16(22-15)17(20)19-10-11-3-2-4-13(18)7-11/h2-9H,10H2,1H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of CLK1/4 in human MDA-MB-231 cells assessed as down regulation of S6 kinase expression after 3 days by Western blot analysis				J Med Chem 60: 5377-5391 (2017) Article DOI: 10.1021/acs.jmedchem.6b01915 BindingDB Entry DOI: 10.7270/Q2862JMM
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50239787 (CHEMBL4094143) Show SMILES COc1ccc2sc(cc2c1)C(=O)NCc1cccc(F)c1 Show InChI InChI=1S/C17H14FNO2S/c1-21-14-5-6-15-12(8-14)9-16(22-15)17(20)19-10-11-3-2-4-13(18)7-11/h2-9H,10H2,1H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of CLK1/4 in human MDA-MB-231 cells assessed as down regulation of EGFR expression after 3 days by Western blot analysis				J Med Chem 60: 5377-5391 (2017) Article DOI: 10.1021/acs.jmedchem.6b01915 BindingDB Entry DOI: 10.7270/Q2862JMM
					More data for this Ligand-Target Pair