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Compile Data Set for Download or QSAR

Found 1 hit of ic50 for UniProtKB: P52332   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1/JAK3


(Mus musculus)		BDBM153159
PNG
(BDBM153160 | US8993756, 4-1)
Show SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(C)=C)c3)c12
Show InChI InChI=1S/C19H18N4O3/c1-4-26-19(25)14-9-20-17-15(14)16(21-10-22-17)12-6-5-7-13(8-12)23-18(24)11(2)3/h5-10H,2,4H2,1,3H3,(H,23,24)(H,20,21,22)
PDB

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MCE
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Eberhard-Karls-University Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of JAK3/JAK1 in mouse CTLL-2 cells assessed as reduction in IL2-stimulated STAT5 phosphorylation

Bioorg Med Chem Lett 27: 4229-4237 (2017)


Article DOI: 10.1016/j.bmcl.2017.07.079
BindingDB Entry DOI: 10.7270/Q27P91Z2
More data for this
Ligand-Target Pair