Found 9 hits of ic50 for UniProtKB: P40337 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50459896
(CHEMBL4226250)Show SMILES CN(CCCNc1nc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)cc2)ncc1C1CC1)C(=O)C1CCC1 |r| Show InChI InChI=1S/C56H79N9O9S/c1-38-49(75-37-60-38)41-16-14-39(15-17-41)33-58-52(68)47-32-44(66)35-65(47)54(70)50(56(2,3)4)62-48(67)36-73-30-10-28-71-26-6-7-27-72-29-11-31-74-45-22-20-43(21-23-45)61-55-59-34-46(40-18-19-40)51(63-55)57-24-9-25-64(5)53(69)42-12-8-13-42/h14-17,20-23,34,37,40,42,44,47,50,66H,6-13,18-19,24-33,35-36H2,1-5H3,(H,58,68)(H,62,67)(H2,57,59,61,63)/t44-,47+,50-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | |
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50099062
(CHEMBL3344081 | US10730870, Example 3 | US11512083...)Show SMILES CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C |r| Show InChI InChI=1S/C24H32N4O4S/c1-14-20(33-13-26-14)17-8-6-16(7-9-17)11-25-22(31)19-10-18(30)12-28(19)23(32)21(24(3,4)5)27-15(2)29/h6-9,13,18-19,21,30H,10-12H2,1-5H3,(H,25,31)(H,27,29)/t18-,19+,21-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50459898
(CHEMBL4227907)Show SMILES CN(CCCNc1nc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)cc2)ncc1Br)C(=O)C1CCC1 |r| Show InChI InChI=1S/C53H74BrN9O9S/c1-36-46(73-35-58-36)38-16-14-37(15-17-38)31-56-49(66)44-30-41(64)33-63(44)51(68)47(53(2,3)4)60-45(65)34-71-28-10-26-69-24-6-7-25-70-27-11-29-72-42-20-18-40(19-21-42)59-52-57-32-43(54)48(61-52)55-22-9-23-62(5)50(67)39-12-8-13-39/h14-21,32,35,39,41,44,47,64H,6-13,22-31,33-34H2,1-5H3,(H,56,66)(H,60,65)(H2,55,57,59,61)/t41-,44+,47-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | |
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50459907
(CHEMBL4225691)Show SMILES CC(C)[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C |r| Show InChI InChI=1S/C52H72BrN9O9S/c1-35(2)46(51(67)62-32-41(63)29-44(62)49(65)55-30-37-13-15-38(16-14-37)47-36(3)57-34-72-47)59-45(64)33-70-27-9-25-68-23-5-6-24-69-26-10-28-71-42-19-17-40(18-20-42)58-52-56-31-43(53)48(60-52)54-21-8-22-61(4)50(66)39-11-7-12-39/h13-20,31,34-35,39,41,44,46,63H,5-12,21-30,32-33H2,1-4H3,(H,55,65)(H,59,64)(H2,54,56,58,60)/t41-,44+,46+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | |
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50459913
(CHEMBL4227623)Show SMILES CC[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C |r| Show InChI InChI=1S/C51H70BrN9O9S/c1-4-43(50(66)61-32-40(62)29-44(61)48(64)54-30-36-13-15-37(16-14-36)46-35(2)56-34-71-46)58-45(63)33-69-27-9-25-67-23-5-6-24-68-26-10-28-70-41-19-17-39(18-20-41)57-51-55-31-42(52)47(59-51)53-21-8-22-60(3)49(65)38-11-7-12-38/h13-20,31,34,38,40,43-44,62H,4-12,21-30,32-33H2,1-3H3,(H,54,64)(H,58,63)(H2,53,55,57,59)/t40-,43+,44+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | |
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50459906
(CHEMBL4226773)Show SMILES CCC[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C |r| Show InChI InChI=1S/C52H72BrN9O9S/c1-4-11-44(51(67)62-33-41(63)30-45(62)49(65)55-31-37-14-16-38(17-15-37)47-36(2)57-35-72-47)59-46(64)34-70-28-9-26-68-24-5-6-25-69-27-10-29-71-42-20-18-40(19-21-42)58-52-56-32-43(53)48(60-52)54-22-8-23-61(3)50(66)39-12-7-13-39/h14-21,32,35,39,41,44-45,63H,4-13,22-31,33-34H2,1-3H3,(H,55,65)(H,59,64)(H2,54,56,58,60)/t41-,44+,45+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | |
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50459899
(CHEMBL4226398)Show SMILES C[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C |r| Show InChI InChI=1S/C50H68BrN9O9S/c1-34-45(70-33-55-34)37-14-12-36(13-15-37)29-53-47(63)43-28-40(61)31-60(43)48(64)35(2)56-44(62)32-68-26-8-24-66-22-4-5-23-67-25-9-27-69-41-18-16-39(17-19-41)57-50-54-30-42(51)46(58-50)52-20-7-21-59(3)49(65)38-10-6-11-38/h12-19,30,33,35,38,40,43,61H,4-11,20-29,31-32H2,1-3H3,(H,53,63)(H,56,62)(H2,52,54,57,58)/t35-,40+,43-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | |
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50459905
(CHEMBL4227365)Show SMILES CN(CCCNc1nc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)NCC(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)cc2)ncc1Br)C(=O)C1CCC1 |r| Show InChI InChI=1S/C49H66BrN9O9S/c1-34-45(69-33-55-34)36-13-11-35(12-14-36)28-53-47(63)42-27-39(60)31-59(42)44(62)30-52-43(61)32-67-25-7-23-65-21-3-4-22-66-24-8-26-68-40-17-15-38(16-18-40)56-49-54-29-41(50)46(57-49)51-19-6-20-58(2)48(64)37-9-5-10-37/h11-18,29,33,37,39,42,60H,3-10,19-28,30-32H2,1-2H3,(H,52,61)(H,53,63)(H2,51,54,56,57)/t39-,42+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | |
Elongin-B/Elongin-C/Hypoxia-inducible factor 1-alpha/von Hippel-Lindau disease tumor suppressor
(Homo sapiens (Human)) | BDBM50459909
(CHEMBL4226693)Show SMILES CN(CCCNc1nc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)cc2)ncc1Br)C(=O)C1CCC1 |r| Show InChI InChI=1S/C53H74BrN9O9S/c1-36-46(73-35-58-36)38-16-14-37(15-17-38)31-56-49(66)44-30-41(64)33-63(44)51(68)47(53(2,3)4)60-45(65)34-71-28-10-26-69-24-6-7-25-70-27-11-29-72-42-20-18-40(19-21-42)59-52-57-32-43(54)48(61-52)55-22-9-23-62(5)50(67)39-12-8-13-39/h14-21,32,35,39,41,44,47,64H,6-13,22-31,33-34H2,1-5H3,(H,56,66)(H,60,65)(H2,55,57,59,61)/t41-,44-,47+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Arvinas LLC
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged VHL/elongin B/elongin C (unknown origin) interaction with HIF1alpha preincubated for 10 mins followed by fluorescin labelled... |
J Med Chem 61: 583-598 (2018)
Article DOI: 10.1021/acs.jmedchem.7b00635
BindingDB Entry DOI: 10.7270/Q2GM89ZG |
More data for this
Ligand-Target Pair | |
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