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Compile Data Set for Download or QSAR

Found 3 hits of ec50 for monomerid = 373028   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373028
PNG
(US10597366, Compound 233 | US9896418, Compound 233)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)(F)F |r|
Show InChI InChI=1S/C16H9F7O4S/c17-9-2-1-7(5-10(9)18)27-11-3-4-12(28(25,26)16(21,22)23)13-8(11)6-15(19,20)14(13)24/h1-5,14,24H,6H2/t14-/m0/s1
PDB
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n/an/an/an/a 15n/an/an/an/a



Research Triangle Institute



Assay Description
Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...


J Med Chem 50: 3686-95 (2007)


BindingDB Entry DOI: 10.7270/Q2QC05TR
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373028
PNG
(US10597366, Compound 233 | US9896418, Compound 233)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)(F)F |r|
Show InChI InChI=1S/C16H9F7O4S/c17-9-2-1-7(5-10(9)18)27-11-3-4-12(28(25,26)16(21,22)23)13-8(11)6-15(19,20)14(13)24/h1-5,14,24H,6H2/t14-/m0/s1
PDB
MMDB

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n/an/an/an/a 15n/an/an/an/a



Peloton Therapeutics, Inc.

US Patent


Assay Description
VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...


US Patent US10597366 (2020)


BindingDB Entry DOI: 10.7270/Q2M32ZSW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM373028
PNG
(US10597366, Compound 233 | US9896418, Compound 233)
Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)(F)F |r|
Show InChI InChI=1S/C16H9F7O4S/c17-9-2-1-7(5-10(9)18)27-11-3-4-12(28(25,26)16(21,22)23)13-8(11)6-15(19,20)14(13)24/h1-5,14,24H,6H2/t14-/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC sid
UniChem
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n/an/an/an/a 15n/an/an/an/a



The Scripps Research Institute



Assay Description
About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...


J Med Chem 50: 3359-68 (2007)


BindingDB Entry DOI: 10.7270/Q2FN18HM
More data for this
Ligand-Target Pair