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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50316226 ((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
Takeda California Curated by ChEMBL | Assay Description Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomide | Bioorg Med Chem Lett 23: 4501-5 (2013) Article DOI: 10.1016/j.bmcl.2013.06.055 BindingDB Entry DOI: 10.7270/Q2TT4SC9 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50316226 ((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a |
Takeda California Curated by ChEMBL | Assay Description Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay | Bioorg Med Chem Lett 23: 4501-5 (2013) Article DOI: 10.1016/j.bmcl.2013.06.055 BindingDB Entry DOI: 10.7270/Q2TT4SC9 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
