Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human)) | BDBM50505333 (CHEMBL4437173) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 319 | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of tankyrase 1/2 in human DLD1 cells assessed as increase in axin2 accumulation incubated for 24 hrs by luminex based bead assay | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human)) | BDBM50505333 (CHEMBL4437173) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of tankyrase 1/2 mediated auto-PARsylation in human DLD1 cells assessed as increase in tankyrase accumulation incubated for 24 hrs by lumi... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |