Found 4 hits of ec50 for monomerid = 50538344 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50538344
(CHEMBL4633246)Show SMILES Cc1c(Cc2ccc(nc2)C(F)(F)F)c[nH]c1C(=O)NC1CC1 Show InChI InChI=1S/C16H16F3N3O/c1-9-11(8-21-14(9)15(23)22-12-3-4-12)6-10-2-5-13(20-7-10)16(17,18)19/h2,5,7-8,12,21H,3-4,6H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
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MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 by IonWorks patch clamp electrophysiology assay |
J Med Chem 63: 4929-4956 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00311
BindingDB Entry DOI: 10.7270/Q2M90D6Z |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human)) | BDBM50538344
(CHEMBL4633246)Show SMILES Cc1c(Cc2ccc(nc2)C(F)(F)F)c[nH]c1C(=O)NC1CC1 Show InChI InChI=1S/C16H16F3N3O/c1-9-11(8-21-14(9)15(23)22-12-3-4-12)6-10-2-5-13(20-7-10)16(17,18)19/h2,5,7-8,12,21H,3-4,6H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Inhibition of human Cav1.2 by fluorescence based assay |
J Med Chem 63: 4929-4956 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00311
BindingDB Entry DOI: 10.7270/Q2M90D6Z |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50538344
(CHEMBL4633246)Show SMILES Cc1c(Cc2ccc(nc2)C(F)(F)F)c[nH]c1C(=O)NC1CC1 Show InChI InChI=1S/C16H16F3N3O/c1-9-11(8-21-14(9)15(23)22-12-3-4-12)6-10-2-5-13(20-7-10)16(17,18)19/h2,5,7-8,12,21H,3-4,6H2,1H3,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
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MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by IonWorks patch clamp electrophysiology assay |
J Med Chem 63: 4929-4956 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00311
BindingDB Entry DOI: 10.7270/Q2M90D6Z |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50538344
(CHEMBL4633246)Show SMILES Cc1c(Cc2ccc(nc2)C(F)(F)F)c[nH]c1C(=O)NC1CC1 Show InChI InChI=1S/C16H16F3N3O/c1-9-11(8-21-14(9)15(23)22-12-3-4-12)6-10-2-5-13(20-7-10)16(17,18)19/h2,5,7-8,12,21H,3-4,6H2,1H3,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks patch clamp electrophysiology assay |
J Med Chem 63: 4929-4956 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00311
BindingDB Entry DOI: 10.7270/Q2M90D6Z |
More data for this
Ligand-Target Pair | |
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