Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Aerpio Therapeutics Inc. US Patent | Assay Description EGLN enzyme activity assay is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-TOF MS. | US Patent US8536181 (2013) BindingDB Entry DOI: 10.7270/Q2D21W79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 [179-426] (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
AERPIO THERAPEUTICS, INC. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US9278930 (2016) BindingDB Entry DOI: 10.7270/Q24J0CZG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US10562854 (2020) BindingDB Entry DOI: 10.7270/Q2668GK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cadila Healthcare Limited Curated by ChEMBL | Assay Description Inhibition of HIF-PHD2 (unknown origin) expressed in insect Hi5 cells using peptide as substrate | J Med Chem 61: 6964-6982 (2018) Article DOI: 10.1021/acs.jmedchem.7b01686 BindingDB Entry DOI: 10.7270/Q2H70JC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL | Assay Description Inhibition of human recombinant EGLN-1 using DLDLEALAPYIPADDDFQL as substrate after 20 mins by mass spectrophotometric analysis | J Med Chem 56: 9369-402 (2014) Article DOI: 10.1021/jm400386j BindingDB Entry DOI: 10.7270/Q290258T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Aerpio Therapeutics Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8778412 (2014) BindingDB Entry DOI: 10.7270/Q2WS8RZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC. US Patent | Assay Description VEGF: HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following ove... | US Patent US10562854 (2020) BindingDB Entry DOI: 10.7270/Q2668GK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Aerpio Therapeutics Inc. US Patent | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | US Patent US8778412 (2014) BindingDB Entry DOI: 10.7270/Q2WS8RZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AERPIO THERAPEUTICS, INC. US Patent | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | US Patent US9278930 (2016) BindingDB Entry DOI: 10.7270/Q24J0CZG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM102348 (US10562854, No. A41 | US8536181, A41 | US9278930, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Aerpio Therapeutics Inc. US Patent | Assay Description ELISA assay using VEGF. | US Patent US8536181 (2013) BindingDB Entry DOI: 10.7270/Q2D21W79 | |||||||||||
More data for this Ligand-Target Pair |