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Compile Data Set for Download or QSAR

Found 3 hits of ic50 for monomerid = 130799   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM130799
PNG
(US8829199, 3)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(O)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H27N7O2/c1-15-29-21-5-4-18(12-23(21)30-15)33-26(27)20(13-28-33)25(35)24-11-17-3-2-16(10-22(17)31-24)14-32-8-6-19(34)7-9-32/h2-5,10-13,19,31,34H,6-9,14,27H2,1H3,(H,29,30)
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US Patent
n/an/a 5.30n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM130799
PNG
(US8829199, 3)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(O)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H27N7O2/c1-15-29-21-5-4-18(12-23(21)30-15)33-26(27)20(13-28-33)25(35)24-11-17-3-2-16(10-22(17)31-24)14-32-8-6-19(34)7-9-32/h2-5,10-13,19,31,34H,6-9,14,27H2,1H3,(H,29,30)
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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR2-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM130799
PNG
(US8829199, 3)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(O)CC4)cc3[nH]2)c1N
Show InChI InChI=1S/C26H27N7O2/c1-15-29-21-5-4-18(12-23(21)30-15)33-26(27)20(13-28-33)25(35)24-11-17-3-2-16(10-22(17)31-24)14-32-8-6-19(34)7-9-32/h2-5,10-13,19,31,34H,6-9,14,27H2,1H3,(H,29,30)
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US Patent
n/an/a 13n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR3-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair