Found 3 hits of ic50 for monomerid = 151009 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151009
(US8987257, 22)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG
US Patent
| Assay Description IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM151009
(US8987257, 22)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114498 BindingDB Entry DOI: 10.7270/Q2ZG6XB2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM151009
(US8987257, 22)Show SMILES C[C@H]1COCCN1c1nc(N2CCOC[C@@H]2C)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-12-31-10-8-29(14)22-19-21(27-23(28-22)30-9-11-32-13-15(30)2)26-20(25-19)17-4-3-5-18-16(17)6-7-24-18/h3-7,14-15H,8-13H2,1-2H3/b20-17-/t14-,15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 5.86E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG
US Patent
| Assay Description PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... |
US Patent US8987257 (2015)
BindingDB Entry DOI: 10.7270/Q2S75F2B |
More data for this Ligand-Target Pair | |