Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM158155 (US10081622, Compound 4 | US9029356, 4 | US9255087,...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl Curated by ChEMBL | Assay Description Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATP | J Med Chem 59: 3392-408 (2016) Article DOI: 10.1021/acs.jmedchem.6b00064 BindingDB Entry DOI: 10.7270/Q27M09TG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM158155 (US10081622, Compound 4 | US9029356, 4 | US9255087,...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 207 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co... | US Patent US9029356 (2015) BindingDB Entry DOI: 10.7270/Q29C6W5G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aurora kinase B (Homo sapiens (Human)) | BDBM158155 (US10081622, Compound 4 | US9029356, 4 | US9255087,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 484 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe... | US Patent US9029356 (2015) BindingDB Entry DOI: 10.7270/Q29C6W5G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM158155 (US10081622, Compound 4 | US9029356, 4 | US9255087,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl Curated by ChEMBL | Assay Description Inhibition of IGF1R (unknown origin) in presence of gamma33-ATP | J Med Chem 59: 3392-408 (2016) Article DOI: 10.1021/acs.jmedchem.6b00064 BindingDB Entry DOI: 10.7270/Q27M09TG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM158155 (US10081622, Compound 4 | US9029356, 4 | US9255087,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl Curated by ChEMBL | Assay Description Inhibition of IR (unknown origin) in presence of gamma33-ATP | J Med Chem 59: 3392-408 (2016) Article DOI: 10.1021/acs.jmedchem.6b00064 BindingDB Entry DOI: 10.7270/Q27M09TG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM158155 (US10081622, Compound 4 | US9029356, 4 | US9255087,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences S.R.L. US Patent | Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.A spe... | US Patent US9029356 (2015) BindingDB Entry DOI: 10.7270/Q29C6W5G | |||||||||||
More data for this Ligand-Target Pair |