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Compile Data Set for Download or QSAR

Found 2 hits of ic50 for monomerid = 186832   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]


(Homo sapiens (Human))
BDBM186832
PNG
(US9670203, Compound 1.24)
Show SMILES Cc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccc1F |r|
Show InChI InChI=1S/C25H21FN4O4/c1-12-10-13(2-5-17(12)26)28-25(32)30-22-21-16-11-14(3-6-18(16)34-23(21)22)33-19-8-9-27-24-15(19)4-7-20(31)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 370n/an/an/an/an/a25



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)


BindingDB Entry DOI: 10.7270/Q20Z71F5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf [416-766,V600E]


(Homo sapiens (Human))
BDBM186832
PNG
(US9670203, Compound 1.24)
Show SMILES Cc1cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)ccc1F |r|
Show InChI InChI=1S/C25H21FN4O4/c1-12-10-13(2-5-17(12)26)28-25(32)30-22-21-16-11-14(3-6-18(16)34-23(21)22)33-19-8-9-27-24-15(19)4-7-20(31)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,29,31)(H2,28,30,32)/t21-,22-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+3n/an/an/an/an/a25



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)


BindingDB Entry DOI: 10.7270/Q20Z71F5
More data for this
Ligand-Target Pair