Found 4 hits of ic50 for monomerid = 218886 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Casein kinase II subunit alpha/beta
(Homo sapiens (Human)-Rattus norvegicus) | BDBM218886
(US9303033, O36, Table 41A, Compound 1 | US9303033,...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1 |r,wU:1.0,wD:4.7,(-8.26,1.91,;-6.92,1.14,;-5.59,1.91,;-4.25,1.14,;-4.25,-.4,;-5.59,-1.17,;-6.92,-.4,;-2.92,-1.17,;-1.59,-.4,;-1.59,1.14,;-.25,1.91,;-.25,3.45,;1.08,4.22,;2.62,4.22,;1.85,5.56,;1.08,1.14,;2.54,1.62,;3.45,.37,;2.54,-.87,;2.94,-2.36,;4.43,-2.76,;5.68,-1.85,;6.92,-2.76,;8.26,-1.99,;6.45,-4.22,;4.91,-4.22,;4.14,-5.56,;1.08,-.4,;-.25,-1.17,)| Show InChI InChI=1S/C19H24N8O2/c20-11-1-3-12(4-2-11)22-15-8-16(23-13-5-6-13)27-17(25-15)10(9-21-27)7-14-18(28)26-19(29)24-14/h7-9,11-13,23H,1-6,20H2,(H,22,25)(H2,24,26,28,29)/b14-7-/t11-,12- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.2 | n/a |
SENHWA BIOSCIENCES, INC.
US Patent
| Assay Description In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ... |
US Patent US9303033 (2016)
BindingDB Entry DOI: 10.7270/Q2CN72RX |
More data for this Ligand-Target Pair | |
Casein kinase II subunit alpha/beta
(Homo sapiens (Human)-Rattus norvegicus) | BDBM218886
(US9303033, O36, Table 41A, Compound 1 | US9303033,...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1 |r,wU:1.0,wD:4.7,(-8.26,1.91,;-6.92,1.14,;-5.59,1.91,;-4.25,1.14,;-4.25,-.4,;-5.59,-1.17,;-6.92,-.4,;-2.92,-1.17,;-1.59,-.4,;-1.59,1.14,;-.25,1.91,;-.25,3.45,;1.08,4.22,;2.62,4.22,;1.85,5.56,;1.08,1.14,;2.54,1.62,;3.45,.37,;2.54,-.87,;2.94,-2.36,;4.43,-2.76,;5.68,-1.85,;6.92,-2.76,;8.26,-1.99,;6.45,-4.22,;4.91,-4.22,;4.14,-5.56,;1.08,-.4,;-.25,-1.17,)| Show InChI InChI=1S/C19H24N8O2/c20-11-1-3-12(4-2-11)22-15-8-16(23-13-5-6-13)27-17(25-15)10(9-21-27)7-14-18(28)26-19(29)24-14/h7-9,11-13,23H,1-6,20H2,(H,22,25)(H2,24,26,28,29)/b14-7-/t11-,12- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.2 | n/a |
SENHWA BIOSCIENCES, INC.
US Patent
| Assay Description In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ... |
US Patent US9303033 (2016)
BindingDB Entry DOI: 10.7270/Q2CN72RX |
More data for this Ligand-Target Pair | |
Casein kinase II subunit beta
(Homo sapiens (Human)) | BDBM218886
(US9303033, O36, Table 41A, Compound 1 | US9303033,...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1 |r,wU:1.0,wD:4.7,(-8.26,1.91,;-6.92,1.14,;-5.59,1.91,;-4.25,1.14,;-4.25,-.4,;-5.59,-1.17,;-6.92,-.4,;-2.92,-1.17,;-1.59,-.4,;-1.59,1.14,;-.25,1.91,;-.25,3.45,;1.08,4.22,;2.62,4.22,;1.85,5.56,;1.08,1.14,;2.54,1.62,;3.45,.37,;2.54,-.87,;2.94,-2.36,;4.43,-2.76,;5.68,-1.85,;6.92,-2.76,;8.26,-1.99,;6.45,-4.22,;4.91,-4.22,;4.14,-5.56,;1.08,-.4,;-.25,-1.17,)| Show InChI InChI=1S/C19H24N8O2/c20-11-1-3-12(4-2-11)22-15-8-16(23-13-5-6-13)27-17(25-15)10(9-21-27)7-14-18(28)26-19(29)24-14/h7-9,11-13,23H,1-6,20H2,(H,22,25)(H2,24,26,28,29)/b14-7-/t11-,12- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 253 | n/a | n/a | n/a | n/a | 7.0 | n/a |
SENHWA BIOSCIENCES, INC.
US Patent
| Assay Description Test compounds dissolved and diluted in DMSO (2 μl) were added to a reaction mixture comprising 10 μl of 5× Reaction Buffer (40 mM MOPS pH ... |
US Patent US9303033 (2016)
BindingDB Entry DOI: 10.7270/Q2CN72RX |
More data for this Ligand-Target Pair | |
Casein kinase II subunit beta
(Homo sapiens (Human)) | BDBM218886
(US9303033, O36, Table 41A, Compound 1 | US9303033,...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1 |r,wU:1.0,wD:4.7,(-8.26,1.91,;-6.92,1.14,;-5.59,1.91,;-4.25,1.14,;-4.25,-.4,;-5.59,-1.17,;-6.92,-.4,;-2.92,-1.17,;-1.59,-.4,;-1.59,1.14,;-.25,1.91,;-.25,3.45,;1.08,4.22,;2.62,4.22,;1.85,5.56,;1.08,1.14,;2.54,1.62,;3.45,.37,;2.54,-.87,;2.94,-2.36,;4.43,-2.76,;5.68,-1.85,;6.92,-2.76,;8.26,-1.99,;6.45,-4.22,;4.91,-4.22,;4.14,-5.56,;1.08,-.4,;-.25,-1.17,)| Show InChI InChI=1S/C19H24N8O2/c20-11-1-3-12(4-2-11)22-15-8-16(23-13-5-6-13)27-17(25-15)10(9-21-27)7-14-18(28)26-19(29)24-14/h7-9,11-13,23H,1-6,20H2,(H,22,25)(H2,24,26,28,29)/b14-7-/t11-,12- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 878 | n/a | n/a | n/a | n/a | 7.0 | n/a |
SENHWA BIOSCIENCES, INC.
US Patent
| Assay Description 5 uM ATP: Test compounds dissolved and diluted in DMSO (2 μl) were added to a reaction mixture comprising 10 μl of 5× Reaction Buffer (40 m... |
US Patent US9303033 (2016)
BindingDB Entry DOI: 10.7270/Q2CN72RX |
More data for this Ligand-Target Pair | |